Issue 10, 2009
From the journal:

Molecular BioSystems

Understanding apoptosis by systems biology approaches

Inna N. Lavrik,†*ac   Roland Eils,†bcd   Nicolai Fricker,ac   Carina Pforra  and  Peter H. Krammera  

* Corresponding authors

a Division of Immunogenetics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany

b Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany

c Bioquant, University of Heidelberg, 69120 Heidelberg, Germany

d Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology, University of Heidelberg, 69120 Heidelberg, Germany

Abstract

Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. Recently, a substantial step forward in understanding the complex apoptotic pathways has been made by utilising systems biology approaches. Systems biology combines rigorous mathematical modelling with experimental approaches in a closed loop cycle for advancing our knowledge about complex biological processes. In this review we describe the contemporary systems biology studies devoted to apoptotic signalling and focus on the question of how systems biology helps to understand life/death decisions made in the cell and to develop new approaches to rational treatment strategies.

Graphical abstract: Understanding apoptosis by systems biology approaches

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Article information

DOI
https://doi.org/10.1039/B905129P
Article type
Review Article
Submitted
12 Mar 2009
Accepted
09 Jul 2009
First published
03 Aug 2009

Mol. BioSyst., 2009,5, 1105-1111

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Understanding apoptosis by systems biology approaches

I. N. Lavrik, R. Eils, N. Fricker, C. Pforr and P. H. Krammer, Mol. BioSyst., 2009, 5, 1105 DOI: 10.1039/B905129P

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