Issue 76, 2017, Issue in Progress
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RSC Advances

Natural terpenoid glycosides with in vitro/vivo antithrombotic profiles from the leaves of Crataegus pinnatifida†

Pin-Yi Gao,ab   Ling-Zhi Li,*a   Ke-Chun Liu,c   Chen Sun,c   Xue Sun,a   Ya-Nan Wua  and  Shao-Jiang Song ORCID logo *a  

* Corresponding authors

a Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China
E-mail: songsj99@163.com, lilingzhijessie@163.com

b College of Pharmaceutical and Biotechnology Engineering, Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang 110142, People's Republic of China

c Biology Institute of Shandong Academy of Sciences, Jinan, People's Republic of China

Abstract

Two norditerpenoids (1–2) with unique carbon skeletons, four sesquiterpenoids (3–6) and nine nor-sesquiterpenoids (7–15) were isolated from the leaves of Crataegus pinnatifida and evaluated as possessing antithrombotic activities in vitro/vivo. Their structures with absolute configurations were determined via a combination of spectroscopic data, chemical methods, and quantum-chemical calculations (ECD, NMR, and OR data). Compound 3 showed an inhibitory effect on ADP induced platelet aggregation in vitro, which is mediated through the response to the specific receptor of P2Y12 by docking results. Compound 3 also clearly prolonged the time to form thrombocytes induced by FeCl3, in the caudal vessels of zebrafish.

Graphical abstract: Natural terpenoid glycosides with in vitro/vivo antithrombotic profiles from the leaves of Crataegus pinnatifida

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Article information

DOI
https://doi.org/10.1039/C7RA10768D
Article type
Paper
Submitted
29 Sep 2017
Accepted
09 Oct 2017
First published
16 Oct 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 48466-48474

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Natural terpenoid glycosides with in vitro/vivo antithrombotic profiles from the leaves of Crataegus pinnatifida

P. Gao, L. Li, K. Liu, C. Sun, X. Sun, Y. Wu and S. Song, RSC Adv., 2017, 7, 48466 DOI: 10.1039/C7RA10768D

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