Skip to main content

Advertisement

SpringerLink
Log in

Diffusion tensor imaging of subcortical brain injury in patients infected with human immunodeficiency virus

  • Published:
Journal of NeuroVirology Aims and scope Submit manuscript

Abstract

Diffusion tensor imaging (DTI) was used to derive in vivo tissue status measurements of subcortical brain regions that are vulnerable to injury in human immunodeficiency virus (HIV)-infected patients. Quantitative measurements, including the mean diffusivity (MD) and fractional anisotropy (FA), were determined in lateralized basal ganglia (caudate and putamen) and centrum semiovale in 11 well-characterized HIV patients and in 11 control subjects. DTI measurements were examined for patterns of relationship with markers of clinical and cognitive progression. DTI measures acquired in subcortical regions were significantly correlated with loss of function in specific cognitive domains. Significant relationships were identified between measures for putamen and verbal memory (MD), visual memory (FA), working memory (FA), and overall cognitive impairment (MD). Measures for caudate (FA) were significantly correlated with visual memory. Measures for centrum semiovale were significantly correlated with visual memory deficits (MD) and visuoconstruction (FA). Relationships between anisotropy measures and anemia (basal ganglia) and CD4 counts (centrum semiovale) were also observed. Findings from this investigation indicate that DTI is a sensitive tool for correlating neuroanatomic pathologic features with specific cognitive deficits in patients with HIV infection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • An H, Chen Y, Smith KJ, Hall C, Robertson K, Wilber K, Robertson W, Kwock L, Lin W (2004). Whole brain fractional anisotropy analysis in HIV patients with elastic registration. [Abstract] International Society of Magnetic Resonance in Medicine, 2483, Kyoto, Japan, May 2004.

  • Avison MJ, Nath A, Berger JR (2002). Understanding pathogenesis and treatment of HIV dementia: a role for magnetic resonance. Trends Neurosci 25: 468–473.

    Article  CAS  PubMed  Google Scholar 

  • Aylward EH, Brettschneider PD, McArthur JC, Harris GJ, Schlaepfer TE, Henderer JD, Barta PE, Tien AY, Pearlson GD (1995). Magnetic resonance imaging measurement of gray matter volume reductions in HIV dementia. Am J Psychiatry 152: 987–994.

    CAS  PubMed  Google Scholar 

  • Basser PJ, Pierpaoli C (1996). Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J Magn Reson B 111: 209–219.

    Article  CAS  PubMed  Google Scholar 

  • Bell JE (1998). The neuropathology of adult HIV infection. Rev Neurol 154: 816–829.

    CAS  PubMed  Google Scholar 

  • Bencherif B, Rottenberg DA (1998). Neuroimaging of the AIDS dementia complex. AIDS 12: 233–244.

    CAS  PubMed  Google Scholar 

  • Benton AL (1955). The Visual Retention Test. New York: The Psychological Corporation.

    Google Scholar 

  • Carasig D, Chang L, Arnold S, Tomasi D, Cloak C, Ernst T. (2003). A voxel-based morphometric study of HIV-1 patients at 4 tesla. [Abstract] International Society of Magnetic Resonance in Medicine, 2638, Toronto, Canada, July 2003.

  • Cherner M, Masliah E, Ellis RJ, Marcotte TD, Moore DJ, Grant I, Heaton RK (2002). Neurocognitive dysfunction predicts postmortem findings of HIV encephalitis. Neurology 59: 1563–1567.

    CAS  PubMed  Google Scholar 

  • Cloak CC, Chang L, Miller E, Ernst T (2003). Increased subcortical diffusion is associated with poorer cognitive scores in HIV [Abstract]. International Society of Magnetic Resonance in Medicine, 2239.

  • Concha M, Selnes OA, McArthur J, Nance-Sproson T, Updike ML, Royal W 3rd, Solomon L, Vlahov D (1995). Normative data for a brief neuropsychologic test battery in a cohort of injecting drug users. Intl J Addict 30: 832–841.

    Google Scholar 

  • Everall IP, Chong WK, Wilkinson ID, Paley MN, Chinn RJ, Hall-Craggs MA, Scaravilli F, Lantos PL, Luthert PJ, Harrison MJ (1997). Correlation of MRI and neuropathology in AIDS. J Neurol Neurosurg Psychiatry 62: 92–95.

    Article  CAS  PubMed  Google Scholar 

  • Fahn S, Marsden C, Calne D (1987). Developments in Parkinson’s disease. Florham Park, New Jersey: Macmillan Healthcare Information.

    Google Scholar 

  • Filippi CG, Ulug AM, Ryan E, Ferrando SJ, van Gorp W (2001). Diffusion tensor imaging of patients with HIV and normal-appearing white matter on MR images of the brain. AJNR Am J Neuroradiol 22: 277–283.

    CAS  PubMed  Google Scholar 

  • Filippi M, Grossman RI (2002). MRI techniques to monitor MS evolution: the present and the future. Neurology 58: 1147–1153.

    PubMed  Google Scholar 

  • Flowers KA, Robertson C (1985). The effects of Parkinson’s disease on the ability to maintain a mental set. J Neurol Neurosurg Psychiatr 48: 517–529.

    Article  CAS  PubMed  Google Scholar 

  • Gartner S (2000). HIV infection and dementia. Science 287: 602–604.

    Article  CAS  PubMed  Google Scholar 

  • Gartner S, Liu Y (2002). Insights into the role of immune activation in HIV neuropathogenesis. J NeuroVirol 8: 69–75.

    Article  CAS  PubMed  Google Scholar 

  • Gass A, Niendorf T, Hirsch JG (2001). Acute and chronic changes of the apparent diffusion coefficient in neurological disorders-biophysical mechanisms and possible underlying histopathology. J Neurol Sci 186: S15-S23.

    Article  PubMed  Google Scholar 

  • Green HA, Pena A, Price CJ, Warburton EA, Pickard JD, Carpenter TA, Gillard JH (2002). Increased anisotropy in acute stroke: a possible explanation. Stroke 33: 1517–1521.

    Article  PubMed  Google Scholar 

  • He JZ, Greco JB, Mui K, Aminipour S, Kim J, Fuller R, Rataj E, Lentz M, Sehgal P, Westmoreland SV, de Crespigny A, Gonzalex RG (2003). Diffusion MR detection of early white matter changes in the SIV primate model of neuroaids. [Abstract] International Society of Magnetic Resonance in Medicine, 2536.

  • Horsfield MA, Jones DK (2002). Applications of diffusion-weighted and diffusion tensor MRI to white matter diseases—a review. NMR Biomed 15: 570–577.

    Article  PubMed  Google Scholar 

  • Klove H (1963). Clinical neuropsychology. Med Clin North Am 46: 1647–1658.

    Google Scholar 

  • Le Bihan D (2003). Looking into the functional architecture of the brain with diffusion MRI. Nat Rev Neurosci 4: 469–480.

    Article  PubMed  Google Scholar 

  • Lipton SA, Gendelman HE (1995). Seminars in medicine of the Beth Israel Hospital, Boston. Dementia associated with the acquired immunodeficiency syndrome. N Engl J Med 332: 934–940.

    Article  CAS  PubMed  Google Scholar 

  • Marder K, The Dana Consortium on therapy for HIV dementia and related cognitive disorders (1996). Clinical confirmation of the American Academy of Neurology algorithm for HIV-1-associated cognitive/motor disorder. Neurology 47: 1247–1253.

    Google Scholar 

  • Marder K, Albert SM, McDermott MP, McArthur JC, Schifitto G, Selnes OA, Sacktor N, Stern Y, Palumbo D, Kieburtz K, Cohen B, Orme C, Epstein LG (2003). Interrater reliability of a clinical staging of HIV-associated cognitive impairment. Neurology 60: 1467–1473.

    CAS  PubMed  Google Scholar 

  • McArthur J, Hoover D, Bacellar H, Miller EN, Cohen BA, Becker JT, Graham NM, McArthur JH, Selnes OA, Jacobson LP, Visscher BR, Concha M, Saah A (1993). Dementia in AIDS patients: incidence and risk factors. Multicenter AIDS Cohort Study. Neurology 43: 2245–2252.

    CAS  PubMed  Google Scholar 

  • Middleton FA, Strick PL (2000). Basal ganglia and cerebellar loops: motor and cognitive circuits. Brain Res Rev 31: 236–250.

    Article  CAS  PubMed  Google Scholar 

  • Miller EN, Satz P, Visscher B (1991). Computerized and conventional neuropsychological assessment of HIV-1 infected homosexual men. Neurology 41: 1608–1616.

    CAS  PubMed  Google Scholar 

  • Mottershead JP, Schmierer K, Clemence M, Thornton JS, Scaravilli F, Barker GJ, Tofts PS, Newcombe J, Cuzner ML, Ordidge RJ, McDonald WI, Miller DH (2003). High field MRI correlates of myelin content and axonal density in multiple sclerosis. A post-mortem study of the spinal cord. J Neurol 250: 1293–1301.

    Article  CAS  PubMed  Google Scholar 

  • Moyle G. (2002). Anaemia in persons with HIV infection: prognostic marker and contributor to morbidity. AIDS Rev 4: 13–20.

    PubMed  Google Scholar 

  • Nebuloni M, Pellegrinelli A, Ferri A, Bonetto S, Boldorini R, Vago L, Grassi MP, Constanzi G (2001). Beta amyloid precursor protein and patterns of HIV p24 immunohistochemistry in different brain areas of AIDS patients. AIDS 15: 571–575.

    Article  CAS  PubMed  Google Scholar 

  • Nelson PT, Soma LA, Lavi E (2002). Microglia in diseases of the central nervous system. Ann Med 34: 491–500.

    Article  CAS  PubMed  Google Scholar 

  • Pomara N, Crandall DT, Choi SJ, Johnson G, Lim KO (2001). White matter abnormalities in HIV-1 infection: a diffusion tensor imaging study. Psychiatry Res 106: 15–24.

    Article  CAS  PubMed  Google Scholar 

  • Ragin AB, Storey P, Cohen BA, Edelman RR, Epstein LG (2004a). Disease burden in HIV-associated cognitive impairment: a study of whole brain imaging measures. Neurology 63: 2293–2297.

    CAS  PubMed  Google Scholar 

  • Ragin AB, Storey P, Cohen BA, Epstein LG, Edelman RR (2004b). Whole brain diffusion tensor imaging in HIV-associated cognitive impairment. AJNR Am J Neuroradiol 25: 195–200.

    PubMed  Google Scholar 

  • Raja F, Sherriff FE, Morris CS, Bridges LR, Esiri MM (1997). Cerebral white matter damage in HIV infection demonstated using β-amyloid precursor protein immunoreactivity. Acta Neuropathol 93: 184–189.

    Article  CAS  PubMed  Google Scholar 

  • Rey A (1941). L’examen psychologique dans les cas d’encephalopathie traumatique. Arch Psychol 28: 286–340.

    Google Scholar 

  • Ring HA, Serra-Mestres J (2002). Neuropsychiatry of the basal ganglia. J Neurol Neurosurg Psychiatr 72: 12–21.

    Article  CAS  PubMed  Google Scholar 

  • Selnes OA, Jacobson L, Machado AM, Becker JT, Wesch J, Miller EN, Visscher B, McArthur JC (1991). Normative data for a brief neuropsychological screening battery. Percept Mot Skills 73: 539–550.

    Article  CAS  PubMed  Google Scholar 

  • Sevigny JJ, Albert SM, McDermott MP, McArthur JC, Sacktor N, Conant K, Schifitto G, Selnes OA, Stern Y, McClernon DR, Palumbo D, Kieburtz K, Riggs G, Cohen B, Epstein LG, Marder K (2004). Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated Dementia. Neurology 63: 2084–2090.

    CAS  PubMed  Google Scholar 

  • Sidtis JJ, Gatsonis C, Price RW, Singer EJ, Collier AC, Richman DD, Hirsch MS, Schaerf FW, Fischl MA, Kieburtz K, Simpson D, Kach MA, Feinberg J, Dafni U, The Aids Clinical Trials Group (1993). Ziduvodine treatment of the AIDS dementia complex—results of a placebo-controlled trial. Ann Neurol 33: 343–349.

    Article  CAS  PubMed  Google Scholar 

  • Smith JJ, Sorensen AG, Thrall JH (2003). Biomarkers in imaging: realizing Radiology’s future. Radiology 227: 633–638.

    Article  PubMed  Google Scholar 

  • Tyor WR, Wesselingh SL, Griffin JW, McArthur JC, Griffin DE (1995). Unifying hypothesis for the pathogenesis of HIV-associated dementia complex, vacuolar myelopathy, and sensory neuropathy. J Acquir Immune Defic Syndr Hum Retrovirol 9: 379–388.

    CAS  PubMed  Google Scholar 

  • Wechsler D (1981). Wechsler Adult Intelligence Scale-Revised. New York: The Psychological Corporation.

    Google Scholar 

  • Yang Q, Tress BM, Barber PA, Desmond PM, Darby DG, Gerraty RP, Li T, Davis SM (1999). Serial study of apparent diffusion coefficient and anisotropy in patients with acute stroke. Stroke 30: 2382–2390.

    CAS  PubMed  Google Scholar 

  • Zgaljardic DJ, Borod JC, Foldi NS, Mattis P (2003). A review of the cognitive and behavioral sequelae of Parkinson’s Disease: relationship to frontostriatal circuitry. Cogn Behav Neurol 16: 193–210.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, Northwestern University, Chicago, Illinois, USA

    Ann B. Ragin, Ying Wu, Pippa Storey & Robert R. Edelman

  2. Department of Neurology, Northwestern University, Chicago, Illinois, USA

    Bruce A. Cohen & Leon G. Epstein

  3. Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

    Leon G. Epstein

  4. Department of Radiology, Evanston Northwestern Healthcare, Evanston, Illinois, USA

    Ying Wu, Pippa Storey & Robert R. Edelman

Authors
  1. Ann B. Ragin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ying Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Pippa Storey
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bruce A. Cohen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Robert R. Edelman
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Leon G. Epstein
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ann B. Ragin.

Additional information

The National Institute of Mental Health (MH66705) and the National Institute of Neurological Disorders and Stroke (NS36519 and NS049465) provided funding or support for this study.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ragin, A.B., Wu, Y., Storey, P. et al. Diffusion tensor imaging of subcortical brain injury in patients infected with human immunodeficiency virus. Journal of NeuroVirology 11, 292–298 (2005). https://doi.org/10.1080/13550280590953799

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1080/13550280590953799

Keywords

Search

Navigation