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Ovarian Cancer
Diagnostic Value of Serum Kallikrein-Related Peptidases 6 and 10 Versus CA125 in Ovarian Cancer
  1. Mustafa Abdel Hafiz El Sherbini, MD*,
  2. Maha Mohamed Sallam, PhD, MD*,
  3. Emtiaz Abdel Kawy Shaban, PhD, MD* and
  4. Amr Hassan El-Shalakany, PhD, MD†
  1. * Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt; and
  2. † Gynecological Oncology Unit, Ain Shams University Maternity Hospital, Cairo, Egypt.
  1. Address correspondence and reprint requests to Mustafa Abdel Hafiz El Sherbini, MD, Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. E-mail: me_sherbini{at}yahoo.com.

Abstract

Objectives: To assess the diagnostic value of serum KLK6 and KLK10 in patients with ovarian tumor in comparison to serum CA125.

Methods: Based on clinical and sonographic findings, 90 patients were consecutively recruited at the Gynecological Oncology Unit, Ain Shams University Maternity Hospital. Preoperative serum KLK6 and/or KLK10 were determined by enzyme-linked immunosorbent assay technique. The patients' final diagnoses were those of the histopathological reports.

Results: There were 27 malignant versus 63 benign cases. Serum markers' diagnostic specificity and sensitivity were 80.3/72.7, 56.8/64.0, and 39.53/58.3 for CA125, KLK6, and KLK10, respectively. Combination of CA125 with either of the other 2 markers revealed diagnostic enhancement with KLK10 (85.37/73.00) but not with KLK6 (42.86/86.36).

Conclusions: In ovarian cancer, serum KLK6 and KLK10 may have much lower overall sensitivities than serum CA125. However, whereas serum KLK6 may improve the sensitivity of CA125, serum KLK10 may have the highest specificity among the 3 markers.

  • Ovarian cancer
  • CA125
  • Kallikrein-related peptidases
  • KLK6
  • KLK10

https://doi.org/10.1097/IGC.0b013e31821283c3

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