Treg Cells, Life History, and Diversity
- Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115
- Correspondence: cbdm{at}hms.harvard.edu
Abstract
Regulatory T cells expressing the FoxP3 transcription factor have a profound and nonredundant role in several aspects of immunological tolerance. We will review here the specification of this lineage, its population dynamics, and the diversity of subphenotypes that correlate with their diverse roles in controlling inflammation in a variety of settings.
- Copyright © 2012 Cold Spring Harbor Laboratory Press; all rights reserved
