Features and mechanisms of canonical and noncanonical genomic imprinting
- 1Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, United Kingdom;
- 2Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EG, United Kingdom
- Corresponding author: gavin.kelsey{at}babraham.ac.uk
Abstract
Genomic imprinting is the monoallelic expression of a gene based on parent of origin and is a consequence of differential epigenetic marking between the male and female germlines. Canonically, genomic imprinting is mediated by allelic DNA methylation. However, recently it has been shown that maternal H3K27me3 can result in DNA methylation-independent imprinting, termed “noncanonical imprinting.” In this review, we compare and contrast what is currently known about the underlying mechanisms, the role of endogenous retroviral elements, and the conservation of canonical and noncanonical genomic imprinting.
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Footnotes
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Supplemental material is available for this article.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.348422.121.
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Freely available online through the Genes & Development Open Access option.
This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.
