The Role of Aneuploidy in Cancer Evolution

  1. Charles Swanton1,2
  1. 1Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, Lincoln’s Inn Fields Laboratories, London WC2A 3LY, United Kingdom
  2. 2CRUK Lung Cancer Centre of Excellence/UCL Cancer Institute, London WC1E 6BT, United Kingdom
  1. Correspondence: Charles.Swanton{at}crick.ac.uk

Abstract

Chromosomal aberrations during cell division represent one of the first recognized features of human cancer cells, and modern detection methods have revealed the pervasiveness of aneuploidy in cancer. The ongoing karyotypic changes brought about by chromosomal instability (CIN) contribute to tumor heterogeneity, drug resistance, and treatment failure. Whole-chromosome and segmental aneuploidies resulting from CIN have been proposed to allow “macroevolutionary” leaps that may contribute to profound phenotypic change. In this review, we will outline evidence indicating that aneuploidy and CIN contribute to cancer evolution.

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    1. Published in Advance October 21, 2016, doi: 10.1101/cshperspect.a028373 Cold Spring Harb Perspect Med 7: Copyright © 2017 Cold Spring Harbor Laboratory Press; all rights reserved
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