Regulation of lipid peroxidation and ferroptosis in diverse species
- Marcus Conrad1,
- Valerian E. Kagan2,3,4,5,6,
- Hülya Bayir2,7,
- Gabriela C. Pagnussat8,
- Brian Head9,10,
- Maret G. Traber9,11 and
- Brent R. Stockwell12,13
- 1Institute of Developmental Genetics, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), 85764 Neuherberg, Germany;
- 2Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA;
- 3Department of Environmental Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA;
- 4Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA;
- 5Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA;
- 6Laboratory of Navigational Lipidomics of Cell Death and Regeneration, I.M. Sechenov First Moscow State Medical University, Moscow 119992, Russia;
- 7Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA;
- 8Instituto de Investigaciones Biológicas, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Mar del Plata, 7600 Mar del Plata, Argentina;
- 9Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97330;
- 10Molecular and Cell Biology Graduate Program, Oregon State University, Corvallis, Oregon 97330, USA;
- 11College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon 97330, USA;
- 12Department of Biological Sciences, Columbia University, New York, New York 10027, USA;
- 13Department of Chemistry, Columbia University, New York, New York 10027, USA
- Corresponding author: bstockwell{at}columbia.edu
Abstract
Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q10 react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione and glutathione peroxidase 4 (GPX4) and other components of the cellular antioxidant defense network. Ferroptosis is a form of regulated nonapoptotic cell death involving overwhelming iron-dependent lipid peroxidation. Here, we review the functions and regulation of lipid peroxidation, ferroptosis, and the antioxidant network in diverse species, including humans, other mammals and vertebrates, plants, invertebrates, yeast, bacteria, and archaea. We also discuss the potential evolutionary roles of lipid peroxidation and ferroptosis.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.314674.118.
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