Skip to main content

Advertisement

SpringerLink
Log in

Effect of Variation in Intraluminal Thrombus Constitutive Properties on Abdominal Aortic Aneurysm Wall Stress

  • Published:
Annals of Biomedical Engineering Aims and scope Submit manuscript

Abstract

The abdominal aortic aneurysm (AAA) is a degenerating disease for which the end stage is the rupture of the vessel wall. Accurate prediction of the stresses acting on the aneurysm tissue may be used to determine the actual risk of rupture of a specific aneurysm. To accomplish this, a correct constitutive model for the aneurysmal aortic wall and any intraluminal thrombus (ILT) present within it are needed. Our laboratory has previously reported the mechanical properties of ILT. The aim of this work is to investigate the reliability of using population-mean values of ILT constitutive parameters to estimate AAA wall stress distribution. For this, a three-dimensional asymmetric model of an aneurysm including ILT was generated and a parametric study was conducted varying ILT constitutive properties within a physiological range. Results show that the presence of any ILT reduces and redistributes the stresses in the aortic wall markedly. Maximum variation in the peak wall stresses for all the models analyzed was 5%. Adopting a nonhomogeneous ILT did not alter the stress distribution. On the basis of these results, we infer that population mean parameters for ILT material characteristics can be used to reasonably estimate the wall stresses in patient specific aneurysm models. © 2003 Biomedical Engineering Society.

PAC2003: 8719Rr, 8719Xx, 8710+e

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Adolph, R., D. A. Vorp, D. L. Steed, M. W. Webster, M. V. Kameneva, and S. C. Watkins. Cellular content and permeability of intraluminal thrombus in abdominal aortic aneurysm. J. Vasc. Surg.5:916–926, 1997.

    Google Scholar 

  2. Di Martino, E. S., G. Guadagni, A. Fumero, G. Ballerini, R. Spirito, P. Biglioli, and A. Redaelli. Fluid-structure interaction within realistic three-dimensional models of the aneurysmatic aorta as a guidance to assess the risk of rupture of the aneurysm. Med. Eng. Phys.23:647–655, 2001.

    Google Scholar 

  3. Di Martino, E., S. Mantero, F. Inzoli, G. Melissano, D. Astore, R. Chiesa, and R. Fumero. Biomechanics of abdominal aortic aneurysm in the presence of endoluminal thrombus. Eur. J. Vasc. Endovasc Surg.15:290–299, 1998.

    Google Scholar 

  4. Elger, D. F., D. M. Blackketter, R. S. Budwig, and K. H. Johansen. The influence of shape on the stresses in model abdominal aortic aneurysms. J. Biomech. Eng.118:326–332, 1996.

    Google Scholar 

  5. Harter, L. P., B. H. Gross, P. W. Callen, and R. A. Barth. Ultrasonic evaluation of abdominal aortic thrombus. J. Ultrasound Med.1:315–318, 1982.

    Google Scholar 

  6. Inzoli, F., F. Boschetti, M. Zappa, T. Longo, and R. Fumero. Biomechanical factors in abdominal aortic aneurysm rupture. Eur. J. Vasc. Surg.7:667–674, 1993.

    Google Scholar 

  7. Katz, D. A., B. Littenberg, and J. L. Cronenwett. Management of small abdominal aortic aneurysms. Early surgery vs. watchful waiting. J. Am. Med. Assoc.268:2678–2686, 1992.

    Google Scholar 

  8. Mower, W. R., W. J. Quinones, and S. S. Gambhir. Effect of intraluminal thrombus on abdominal aortic aneurysm wall stress. J. Vasc. Surg.26:602–608, 1997.

    Google Scholar 

  9. Newman, A. B., A. M. Arnold, G. L. Burke, D. H. O'Leary, and T. A. Manolio. Cardiovascular disease and mortality in older adults with small abdominal aortic aneurysms detected by ultrasonography. Ann. Intern Med.134:182–190, 2001.

    Google Scholar 

  10. Raghavan, M. L., and D. A. Vorp. Toward a biomechanical tool to evaluate rupture potential of abdominal aortic aneurysm: Identification of a finite strain constitutive model and evaluation of its applicability. J. Biomech.33:475–482, 2000.

    Google Scholar 

  11. Raghavan, M. L., D. A. Vorp, M. P. Federle, M. S. Makaroun, and M. W. Webster. Wall stress distribution on three dimensionally reconstructed models of human abdominal aortic aneurysm. J. Vasc. Surg.31:760–769, 2000.

    Google Scholar 

  12. Raghavan, M. L.and D. A. Vorp. Toward a biomechanical tool to evaluate rupture potential of abdominal aortic aneurysm: Identification of a finite strain constitutive model and evaluation of its applicability. J. Biomech.33:475–482, 2000.

    Google Scholar 

  13. Schurink, G. W. H., J. M. van Baalen, J. M. T. Visser, and J. van Bockel. Thrombus within an aortic aneurysm does not reduce pressure on the aneurismal wall. J. Vasc. Surg.31:501–506, 2000.

    Google Scholar 

  14. Scott, R. A., H. A. Ashton, and M. J. Lamparelli. Vascular surgical society of Great Britain and Ireland: Fifteen years of experience using 6 cm as a criterion for abdominal aortic aneurysm surgery. Br. J. Surg.86:709–710, 1999.

    Google Scholar 

  15. Smith, D. B., M. S. Sacks, D. A. Vorp, and M. Thorton. Surface geometric analysis of anatomic structures using biquintic finite element interpolation. Ann. Biomed. Eng.28:598–611, 2000.

    Google Scholar 

  16. Stringfellow, M. M., P. F. Lawrence, and R. G. Stringfellow. The influence of aorta-aneurysm geometry upon stress in the aneurysm wall. J. Surg. Res.42:425–433, 1987.

    Google Scholar 

  17. Thubrikar, M. J., F. Robicsek, M. Labrosse, V. Chervenkoff, and B. L. Fowler. Effect of thrombus in AAA on pressure and dilation experienced by the aneurysm wall. In: ASME-IMECE Proceedings,New York, 2001.

  18. Vorp, D. A., W. A. Mandarino, M. W. Webster, and J. Gorcsan, II. Potential influence of intraluminal thrombus on abdominal aortic aneurysm as assessed by a new non-invasive method. Cardiovasc. Surg.4:732–739, 1996.

    Google Scholar 

  19. Vorp, D. A., M. L. Raghavan, and M. W. Webster. Mechanical wall stress in abdominal aortic aneurysm: influence of diameter and asymmetry. J. Vasc. Surg.27:632–639, 1998.

    Google Scholar 

  20. Wang, D. H. J., M. S. Makaroun, M. W. Webster, and D. A. Vorp. Mechanical properties and microstructure of intraluminal thrombus from abdominal aortic aneurysm. J. Biomech. Eng.123:536–539, 2001.

    Google Scholar 

  21. Wang, D. H. J., M. S. Makaroun, M. W. Webster, and D. A. Vorp. Effect of intraluminal thrombus on stress distribution in patient specific models of abdominal aortic aneurysm. J. Vasc. Surg.36:598–604, 2002.

    Google Scholar 

  22. Wang, D. H. J., M. S. Makaroun, and D. A. Vorp. Noninvasive estimation of wall strength distribution in human abdominal aortic aneurysm. In: ASME-IMECE Proceedings, New York, 2001.

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, University of Pittsburgh, Pittsburgh, PA

    Elena S. Di Martino & David A. Vorp

  2. Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA

    Elena S. Di Martino & David A. Vorp

Authors
  1. Elena S. Di Martino
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David A. Vorp
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Di Martino, E.S., Vorp, D.A. Effect of Variation in Intraluminal Thrombus Constitutive Properties on Abdominal Aortic Aneurysm Wall Stress. Annals of Biomedical Engineering 31, 804–809 (2003). https://doi.org/10.1114/1.1581880

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1114/1.1581880

Search

Navigation