Abstract
Cryogen spray cooling (CSC) is an effective method to reduce or eliminate epidermal damage during laser treatment of various dermatoses. This study sought to determine the effects of specific cryogen properties on heat removal. Heat removal was quantified using an algorithm that solved an inverse heat conduction problem from internal temperature measurements made within a skin phantom. A nondimensional parameter, the Weber number, characterized the combined effects of droplet velocity, diameter, and surface tension. CSC experiments with laser irradiation were conducted on ex vivo human skin samples to assess the effect of Weber number on epidermal protection. An empirical relationship between heat removal and the difference in droplet temperature and the substrate, droplet velocity, and diameter was obtained. Histological sections of irradiated ex vivo human skin demonstrated that sprays with higher Weber numbers increased epidermal protection. Results indicate that the cryogen film acts as an impediment to heat transfer between the impinging droplets and the substrate. This study offers the importance of Weber number in heat removal and epidermal protection.
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REFERENCES
Aguilar, G., B. Majaron, K. Pope, L. O. Svaasand, E. J. Lavernia, and J. S. Nelson. Influence of nozzle-to-skin distance in cryogen spray cooling for dermatologic laser surgery. Lasers Surg. Med. 28:113–120, 2001.
Alexander, D. J., and S. E. Libretto. An overview of the toxicology of HFA-134a (1,1,1,2-tetrafluoroethane). Hum. Exp. Toxicol. 14:715–720, 1995.
Anderson, R. R., and J. A. Parrish. Selective photothermolysis: Precise microsurgery by selective absorption of pulsed radiation. Science 220:524–527, 1983.
Anvari, B., T. E. Milner, B. S. Tanenbaum, S. Kimel, L. O. Svaasand, and J. S. Nelson. Selective cooling of biological tissues: Application for thermally mediated therapeutic procedures. Phys. Med. Biol. 40:541–252, 1995.
Ashinoff, R., and R. G. Geronemus. Treatment of a port-wine stain in a black patient with the pulsed dye laser. J. Dermatol. Surg. Oncol. 18:147–148, 1992.
Beck, J. V., B. Blackwell, and C. R. St. Clair Jr. Inverse Heat Conduction: Ill-Posed Problems.New York: Wiley, 1985.
Blondino, F. E., and P. R. Byron. Surfactant dissolution and water solubilization in chlorine-free liquified gas propellants. Drug Dev. Ind. Pharm. 24:935–945, 1998.
Chae, H. B., J.W. Schmidt, and M. R. Moldover. Surface tension of refrigerants R123 and R134a. J. Chem. Eng. Data 35:6–8, 1990.
Chang, C. J., B. Anvari, and J. S. Nelson. Cryogen spray cooling for spatially selective photocoagulation of hemangiomas: A new methodology with preliminary clinical reports. Plast. Reconstr. Surg. 102:459–463, 1998.
Chang, C. J., K. M. Kelly, M. J. C. van Gemert, and J. S. Nelson. Comparing the effectiveness of 585-nm vs. 595-nm wavelength pulsed dye laser treatment of port wine stains in conjunction with cryogen spray cooling. Lasers Surg. Med. 31:352–358, 2002.
Chaves, H., A. M. Kubitzek, and F. Obermeier. Dynamic process occurring during the spreading of thin liquid films produced by drop impact on hot walls. Int. J. Heat Fluid Flow 20:470–476, 1999.
Chung, J. H., W. S. Koh, and J. I. Youn. Histological responses of port wine stains in brown skin after 578 nm copper vapor laser treatment. Lasers Surg. Med. 18:358–366, 1996.
Dover, J. S., and K. A. Arndt. New approaches to the treatment of vascular lesions. Lasers Surg. Med. 26:158–163, 2000.
Duck, F. A. Physical Properties of Tissue. A Comprehensive Reference Book. London: Academic Press, 1990.
Ghodbane, M., and J. P. Holman. Experimental study of spray cooling with Freon-113. Int. J. Heat Mass Transfer 34:1163–1174, 1991.
Higashi, Y., and T. Shibata. Surface tension for 1,1,1-trifluoroethane (R-143a), 1,1,1,2-tetraflluoroethane (R134a), 1,1-dichloro-2,2,3,3,3-pentafluoropropane (R-225ca), and 1,3-dichloro-1,2,2,3,3-pentafluoropropane (R-225cb). J. Chem. Eng. Data 42:438–440, 1997.
Ho, W. S., H. H. Chan, S.Y. Ying, and P. C. Chan. Laser treatment of congenital facial port-wine stains: Long-term efficacy and complication in Chinese patients. Lasers Surg. Med. 30:44-47, 2002.
Ibreighith, M., M. Fiebig, L. Leipertz, and G. Wu. Thermal diffusivity of the alternative refrigerants R123, R134a, R142b, and R152a in the liquid phase. Fluid Phase Equlib. 80:323–332, 1992.
Kelly, K. M., J. S. Nelson, G. P. Lask, R. G. Geronemus, and L. J. Bernstein. Cryogen spray cooling in combination with nonablative laser treatment of facial rhytides. Arch. Dermatol. 135:691–694, 1999.
Lask, G., M. Elman, M. Slatkine, A. Waldman, and Z. Rozenberg. Laser-assisted hair removal by selective photothermolysis. Dermatol. Surg. 23:737–739, 1997.
McLinden, M. O., J. S. Gallagher, L. A. Weber, G. Morrison, D. Ward, A. R. H. Goodwin, M. R. Moldover, J. W. Schmidt, H. B. Chae, T. J. Bruno, J. F. Ely, and M. L. Huber. Measurement and formulation of the thermodynamic properties of refrigerants134a (1,1,1,2-tetrafluoroethane) and 123 (1,1-dichloro-2,2,2-trifluoroethane). ASHRAE Trans. 2:263–283, 1989.
Miller, C. A., and P. Neogi. Interfacial Phenomena. New York. Marcel Dekker, 1985.
Nelson, J. S., and S. Kimel. Safety of cryogen spray cooling during pulsed laser treatment of selected dermatoses. Lasers Surg. Med. 26:2–3, 2000.
Nelson, J. S., T. E. Milner, B. Anvari, B. S. Tanenbaum, S. Kimel, L. O. Svaasand, and S. L. Jacques. Dynamic epidermal cooling during pulsed laser treatment of port-wine stain. A new methodology with preliminary clinical evaluation. Arch. Dermatol. 131:695–700, 1995.
Nelson, J. S., T. E. Milner, B. Anvari, B. S. Tanenbaum, L. O. Svaasand, and S. Kimel. Dynamic epidermal cooling in conjunction with laser-induced photothermolysis of port wine stain blood vessels. Lasers Surg. Med. 19:224–229, 1996.
Niemz, M. H. Laser-Tissue Interactions. Berlin: Springer-Verlag, 1996.
Pikkula, B. M., J. H. Torres, J.W. Tunnell, and B. Anvari. Cryogen spray cooling: Effects of droplet size and spray density on heat removal. Lasers Surg. Med. 28:103–112, 2001.
Pikkula, B. M., J. W. Tunnell, and B. Anvari. Methodology for characterizing heat removal mechanism in human skin during cryogen spray cooling. Ann. Biomed. Eng. 31:493–504, 2003.
Rayleigh, O. M. On the theory of the capillary tube. Proc. R. Soc. Lond. Ser. A 92:184–195, 1915.
Ross, E. V., F. P. Sajben, J. Hsia, D. Barnette, C. H. Hiller, and J. R. McKinlay. Nonablative skin remodeling: Selective dermal heating with a mid-infrared laser and contact cooling combination. Lasers Surg. Med. 26:186–195, 2000.
Stolz, G., Jr. Numerical solutions to an inverse problem of heat conduction for simple shapes. J. Heat Transfer 82:20–26, 1960.
Taler, J. Theory of transient experimental techniques for surface heat transfer. Int. J. Heat Mass Transfer 39:3733–3748, 1996.
Torres, J. H., B. Anvari, S. B. Tanenbaum, T. E. Milner, J. C. Yu, and J. S. Nelson. Internal temperature measurements in response to cryogen spray cooling of skin. SPIE Proc. 3590:11–19, 1999. 1140 PIKKULA et al.
Torres, J. H., J. S. Nelson, B. S. Tanenbaum, T. E. Milner, D.M. Goodman, and B. Anvari. Estimation of internal skin temperatures in response to cryogen spray cooling: Implications for laser therapy of port wine stains. IEEE J. Special Topics Quant. Elect. 5:1058–1066, 1999.
Torres, J. H., J. W. Tunnell, B. M. Pikkula, and B. Anvari. An analysis of heat removal during cryogen spray cooling and effects of simultaneous airflow application. Lasers Surg. Med. 28:477–486, 2001.
Tunnell, J.W.,D. Chang, C. Johnston, J. H. Torres, C.W. Patrick, M. J. Miller, S. L. Thomsen, and B. Anvari. In-vivostudy of epidermal protection by cryogen spray cooling during pulsed laser irradiation at high radiant exposures. SPIE Proc. 4609:67–74, 2002.
Tunnell, J.W., J. S. Nelson, J. H. Torres, and B. Anvari. Epidermal protection with cryogen spray cooling during high fluence pulsed dye laser irradiation: An ex vivostudy. Lasers Surg. Med. 27:373–383, 2000.
Tunnell, J. W., J. H. Torres, and B. Anvari. Methodology for estimation of time-dependent surface heat flux due to cryogen spray cooling. Ann. Biomed. Eng. 30:19–33, 2002.
Valeria, B. C., C. C. Dierickx, W. A. Farinelli, D. L. Tai-Yuan, M. Woraphong, and R. R. Anderson. Ruby laser hair removal: Evaluation of long-term efficacy and side effects. Lasers Surg. Med. 26:177–185, 2000.
Verkruysse,W.,B. Majaron, G. Aguilar, L.O. Svaasand, and J. S. Nelson. Dynamics of cryogen deposition relative to heat extraction rate during cryogen spray cooling. SPIE Proc. 3907:37–48, 2000.
Zenzie, H. H., G. B. Altshuler, M. Z. Smirnov, and R. R. Anderson. Evaluation of cooling methods for laser dermatology. Lasers Surg. Med. 26:130–144, 2000.
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Pikkula, B.M., Tunnell, J.W., Chang, D.W. et al. Effects of Droplet Velocity, Diameter, and Film Height on Heat Removal During Cryogen Spray Cooling. Annals of Biomedical Engineering 32, 1133–1142 (2004). https://doi.org/10.1114/B:ABME.0000036649.80421.60
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DOI: https://doi.org/10.1114/B:ABME.0000036649.80421.60