Novel drug form of chlorin e6

O. Yu. Abakumova; Rudolf Ph. Baum; Natalia Yu. Ermakova; A. T. Gradyushko; T. N. Guseva-Donskaya; Artashes V. Karmenyan; U. M. Koraboyev; V. P. Laptev; V. M. Mechkov; L. M. Mikhailova; N. G. Panferova; Aleksei G. Rebeko; Andrei V. Reshetnickov; M. V. Ryabov; Eugeny Ph. Stranadko; Tatyana A. Tsvetkova; O. S. Zhukova

doi:10.1117/12.375256

30 December 1999 Novel drug form of chlorin e₆

O. Yu. Abakumova, Rudolf Ph. Baum, Natalia Yu. Ermakova, A. T. Gradyushko, T. N. Guseva-Donskaya, Artashes V. Karmenyan, U. M. Koraboyev, V. P. Laptev, V. M. Mechkov, L. M. Mikhailova, N. G. Panferova, Aleksei G. Rebeko, Andrei V. Reshetnickov, M. V. Ryabov, Eugeny Ph. Stranadko, Tatyana A. Tsvetkova, O. S. Zhukova

Author Affiliations +

Proceedings Volume 4059, Laser Use in Oncology II; (1999) https://doi.org/10.1117/12.375256
Event: Selected Papers on Laser Use in Oncology II, 1999, none, Armenia

Abstract

A novel stable water-soluble form of well known photosensitizer chlorin e₆ named `Photodithazine' has been obtained from Spirulina Platensis cyanobacteria as a noncovalent complex with N-methyl-D-glucosamine, and its biological characteristics evaluate, which proved to be as follows: in vitro photocytotoxicity was 1 (mu) M (EC₅₀) as determined by the extent of DNA synthesis inhibition in CaOv cells after irradiation with 650 - 900 nm light, and 5 (mu) M (EC₆₅) as determined using MTT test on PC12 cells after irradiation with 670 nm laser light at the doses of 15 and 20 J/cm², respectively, with Al-sulfophthalocyanine `Photosense' (Russia) and oligomerized hematoporphyrin-IX mixture `Photogen' (Russia) being used as permitted reference drugs.

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O. Yu. Abakumova, Rudolf Ph. Baum, Natalia Yu. Ermakova, A. T. Gradyushko, T. N. Guseva-Donskaya, Artashes V. Karmenyan, U. M. Koraboyev, V. P. Laptev, V. M. Mechkov, L. M. Mikhailova, N. G. Panferova, Aleksei G. Rebeko, Andrei V. Reshetnickov, M. V. Ryabov, Eugeny Ph. Stranadko, Tatyana A. Tsvetkova, and O. S. Zhukova "Novel drug form of chlorin e₆", Proc. SPIE 4059, Laser Use in Oncology II, (30 December 1999); https://doi.org/10.1117/12.375256

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