System for the analysis of whole-bone strength from helical CT images

Jon J. Camp; Ronald A. Karwoski; Mahlon C. Stacy; Elizabeth J. Atkinson; Sundeep Khosla M.D.; L. Joseph Melton M.D.; B. Lawrence Riggs; Richard A. Robb

doi:10.1117/12.535745

30 April 2004 System for the analysis of whole-bone strength from helical CT images

Jon J. Camp, Ronald A. Karwoski, Mahlon C. Stacy, Elizabeth J. Atkinson, Sundeep Khosla M.D., L. Joseph Melton M.D., B. Lawrence Riggs, Richard A. Robb

Author Affiliations +

Proceedings Volume 5369, Medical Imaging 2004: Physiology, Function, and Structure from Medical Images; (2004) https://doi.org/10.1117/12.535745
Event: Medical Imaging 2004, 2004, San Diego, California, United States

Abstract

Osteoporosis affects an estimated 44 million Americans. This condition results from bone loss, but the measured change in bone mass does not fully account for the marked decrease in whole-bone structural integrity seen in osteoporosis. In order to study structural changes in bone mineral distribution due to normal ageing and osteoporosis, we have developed a method for progressive analysis of whole-bone mechanical integrity from helical CT images. The system provides rapid semi-automated alignment of femur and vertebrae volume images into standard anatomic reference planes, and calculates bone mineral density in any selected 3D sections of bone. Mineral density measures are obtained using both full-width-half-max contours and threshold-derived masks, and are obtained for cortical bone and trabecular bone separately. Biomechanical properties of the bone cross-section are also assessed, including the 2-D bending moment of the cortical bone region and the integrated flexural rigidity of the cortical region or whole-bone region in arbitrary planes. This method facilitates progressive refinement of the analysis protocol by separating the labor-intensive alignment and landmark selection process from the analysis process. As the analysis protocol evolves to include new measures, previously analyzed images can be automatically reanalyzed, using the image regions originally specified. Initial results show inverse correlation of indices of biomechanical bone strength with age, greater loss of bone strength in the lumbar spine than in the femoral neck, and more trabecular than cortical bone loss at both sites.

Citation Download Citation

Jon J. Camp, Ronald A. Karwoski, Mahlon C. Stacy, Elizabeth J. Atkinson, Sundeep Khosla M.D., L. Joseph Melton M.D., B. Lawrence Riggs, and Richard A. Robb "System for the analysis of whole-bone strength from helical CT images", Proc. SPIE 5369, Medical Imaging 2004: Physiology, Function, and Structure from Medical Images, (30 April 2004); https://doi.org/10.1117/12.535745

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available