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Optical clearing of human dura mater

  • Geometrical and Applied Optics
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Abstract

The changes in the optical parameters of the human dura mater in the spectral range 400–700 nm caused by the action of an aqueous solution of mannitol with a concentration of 0.16 g/ml are studied in vitro. The diffusion of mannitol into the tissue leads to a partial matching between the refractive indices of the structure-forming elements (the collagen fibrils) and the base substance of the dura mater (the interstitial fluid). As a result, the light scattering by the biological tissue in the entire spectral range under study is decreased, on the average, by a factor of 1.5–2. The immersion of the biological tissue is shown to cause a decrease in the absorption of the dura mater in the range of the blood absorption bands by a factor of 1.2–1.6. The results presented may prove to be useful in the laser therapy and optical diagnostics of brain diseases.

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Authors and Affiliations

  1. Chernyshevsky State University, Saratov, 410012, Russia

    É. A. Genina, A. N. Bashkatov, V. I. Kochubey & V. V. Tuchin

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  1. É. A. Genina
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  2. A. N. Bashkatov
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  3. V. I. Kochubey
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  4. V. V. Tuchin
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__________

Translated from Optika i Spektroskopiya, Vol. 98, No. 3, 2005, pp. 515–521.

Original Russian Text Copyright © 2005 by Genina, Bashkatov, Kochubey, Tuchin.

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Genina, É.A., Bashkatov, A.N., Kochubey, V.I. et al. Optical clearing of human dura mater. Opt. Spectrosc. 98, 470–476 (2005). https://doi.org/10.1134/1.1890530

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  • DOI: https://doi.org/10.1134/1.1890530

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