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Role of 4-hydroxy-trans-2-nonenal in cell functions

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Abstract

The role of lipid peroxidation product 4-hydroxy-trans-2-nonenal (4-HNE) in functional activity of cells under normal and different pathological conditions is discussed. Different pathways of 4-HNE metabolism in tissues are analyzed, with particular focus on the role the glutathione system in this process. 4-HNE is implicated in regulation of cell growth, proliferation, differentiation, and apoptosis. 4-HNE and metabolic products of other antioxidants (carotenoids) resemble each other in chemical nature of the product and influence general pathways of signal transduction. Manifestation of 4-HNE toxicity under oxidative stress conditions is regarded as a link to many diseases whose pathogenesis is connected with modifications of proteins and nucleic acids.

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Abbreviations

AD:

Alzheimer’s disease

ALDH:

NAD+-dependent aldehyde dehydrogenase

AO:

antioxidant

GCL:

glutamate-cysteine ligase (γ-glutamyl-L-cysteine synthetase)

GGTP:

γ-glutamyl transpeptidase

GS:

glutathione synthetase

4-HNE:

4-hydroxy-trans-2-nonenal

IL:

interleukin

LPO:

lipid peroxidation

MDA:

malonic dialdehyde

Nrf2:

zinc-binding protein, an NF-E2 related factor 2

OS:

oxidative stress

PI3K:

phosphatidylinositol 3-kinase

pRb:

retinoblastoma protein

PUFA:

polyunsaturated fatty acid

ROS:

reactive oxygen species

Shc:

SHC-adaptor protein

TNF-α:

tumor necrosis factor alpha

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  1. Bekhterev St. Petersburg Psychoneurological Research Institute, ul. Bekhtereva 3, 192019, St. Petersburg, Russia

    E. E. Dubinina

  2. Mechnikov St. Petersburg State Medical Academy, Piskarevsky pr. 47, 195067, St. Petersburg, Russia

    V. A. Dadali

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Original Russian Text © E. E. Dubinina, V. A. Dadali, 2010, published in Biokhimiya, 2010, Vol. 75, No. 9, pp. 1189–1212.

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Dubinina, E.E., Dadali, V.A. Role of 4-hydroxy-trans-2-nonenal in cell functions. Biochemistry Moscow 75, 1069–1087 (2010). https://doi.org/10.1134/S0006297910090014

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