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Level of blood cell-free circulating mitochondrial DNA as a novel biomarker of acute myocardial ischemia

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Abstract

Changes in the level of blood cell-free circulating mitochondrial DNA were examined during experimental adrenaline-induced myocardial injury in rats. The amount of mitochondrial DNA in the blood was significantly elevated at 48 and 72 h after subcutaneous injection of adrenaline solution, and it was accompanied by development of multiple smallfocal myocardial ischemia. This suggests that the measured level of blood cell-free circulating mitochondrial DNA might be used as a biomarker of acute myocardial ischemia.

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Authors and Affiliations

  1. Irkutsk Surgery and Traumatology Research Center, 664003, Irkutsk, Russia

    N. P. Sudakov, O. A. Goldberg, S. B. Nikiforov, B. G. Pushkarev, S. A. Lepekhova & K. A. Apartsin

  2. Irkutsk State University, 664003, Irkutsk, Russia

    N. P. Sudakov, T. P. Popkova, I. V. Klimenkov & Yu. M. Konstantinov

  3. Irkutsk Research Center, Siberian Branch of the Russian Academy of Sciences, 663033, Irkutsk, Russia

    N. P. Sudakov, S. A. Lepekhova & K. A. Apartsin

  4. Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch of the Russian Academy of Sciences, 664033, Irkutsk, Russia

    A. I. Katyshev & Yu. M. Konstantinov

  5. Limnological Institute, Siberian Branch of the Russian Academy of Sciences, 664033, Irkutsk, Russia

    I. V. Klimenkov

  6. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090, Novosibirsk, Russia

    G. A. Nevinsky

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  1. N. P. Sudakov
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  2. T. P. Popkova
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  5. S. B. Nikiforov
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  6. B. G. Pushkarev
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  7. I. V. Klimenkov
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  8. S. A. Lepekhova
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  11. Yu. M. Konstantinov
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Correspondence to Yu. M. Konstantinov.

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Sudakov, N.P., Popkova, T.P., Katyshev, A.I. et al. Level of blood cell-free circulating mitochondrial DNA as a novel biomarker of acute myocardial ischemia. Biochemistry Moscow 80, 1387–1392 (2015). https://doi.org/10.1134/S000629791510020X

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  • DOI: https://doi.org/10.1134/S000629791510020X

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