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Can efficiency of the photosensitizer be predicted by its photostability in solution?

  • Laser Methods in Chemistry, Biology, and Medicine
  • Published:
Laser Physics

Abstract

We have investigated a possible correlation between the photostability and photodynamic efficacy for different photosensitizers; hematoporphyrin derivatives and chlorines. To perform such analysis, we combined the depth of necrosis (d nec) measurement, expressed by the light threshold dose and a photodegradation parameter, measured from investigation of photosensitizer degradation in solution. The d nec analysis allows us to determine the light threshold dose and compare its value with the existent results in the literature. The use of simple models to understand basic features of Photodynamic Therapy (PDT) may contribute to the solid establishment of dosimetry in PDT, enhancing its use in the clinical management of cancers and others lesions. Using hematoporphyrin derivatives and chlorines photosensitizers we investigated their properties related to the photodegradation in solution and the light threshold dose (D th) in rat livers.

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Authors and Affiliations

  1. Instituto de Fizica de São Carlos-IFSC-University of São Paulo (USP), Av. Trabalhador Sancarlense no. 400, Caixa Postal 369, CEP 13560-970, São Carlos, SP, Brazil

    J. Ferreira, P. F. C. Menezes & V. S. Bagnato

  2. Faculdade de Medicina de Ribeirão Preto-FMRP-University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil

    J. Ferreira, S. Zucoloto & O. Castro e Silva Jr

  3. Brody School of Medicine at East Carolina University, Greenville, NC, USA

    C. H. Sibata & R. R. Allison

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  1. J. Ferreira
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  2. P. F. C. Menezes
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  3. C. H. Sibata
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  4. R. R. Allison
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  5. S. Zucoloto
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  6. O. Castro e Silva Jr
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  7. V. S. Bagnato
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Correspondence to P. F. C. Menezes.

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Original Russian Text © Astro, Ltd., 2009.

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Ferreira, J., Menezes, P.F.C., Sibata, C.H. et al. Can efficiency of the photosensitizer be predicted by its photostability in solution?. Laser Phys. 19, 1932–1938 (2009). https://doi.org/10.1134/S1054660X09170071

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  • DOI: https://doi.org/10.1134/S1054660X09170071

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