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The therapeutic effect of mitochondria-targeted antioxidant SkQ1 and Cistanche deserticola is associated with increased levels of tryptophan and kynurenine in the rat lens

  • Biochemistry, Biophysics and Molecular Biology
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Abstract

Supplementation of senescence-accelerated OXYS rats with the mitochondria-targeted antioxidant SkQ1 and with the powder from Cistanche deserticola results in the deceleration of the cataract development and even in the improvement of lens transparency. The therapeutic effect of these preparations correlates with a significant elevation of tryptophan and kynurenine levels in the lens. This finding is attributed to a deceleration of the tryptophan and kynurenine oxidation due to antioxidant-assisted reduction of oxidative stress in the lens.

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References

  1. Bova, L.M., Sweeney, M.H., Jamie, J.F., and Truscott, R.J.W., Ophthalmol. Vis. Sci., 2001, vol. 42, pp. 200–205.

    CAS  Google Scholar 

  2. Streete, I.M., Jamie, J.F., and Truscott, R.J.W., Invest. Ophthalmol. Vis. Sci., 2004, vol. 45, pp. 4091–4097.

    Article  PubMed  Google Scholar 

  3. Tsentalovich, Yu.P., Snytnikova, O.A., Sherin, P.S., and Forbes, M.D.E., J. Phys. Chem. A, 2005, vol. 109, pp. 3565–3568.

    Article  PubMed  CAS  Google Scholar 

  4. Tsentalovich, Yu.P., Snytnikova, O.A., Forbes, M.D.E., et al., Exp. Eye Res., 2006, vol. 83, pp. 1439–1445.

    Article  PubMed  CAS  Google Scholar 

  5. Snytnikova, O.A., Sherin, P.S., Kopylova, L.V., and Tsentalovich, Yu.P., Izv. Akad. Nauk, Ser. Khim., 2007, vol. 4, pp. 704–710.

    Google Scholar 

  6. Vazquez, S., Aquilina, J.A., Jamie, J.F., et al., J. Biol. Chem., 2002, vol. 277, pp. 4867–4873.

    Article  PubMed  CAS  Google Scholar 

  7. Taylor, L.M., Aquilina, J.A., Jamie, J.F., and Truscott, R.J.W., Exp. Eye Res., 2002, vol. 75, pp. 165–175.

    Article  PubMed  CAS  Google Scholar 

  8. Kopylova, L.V., Snytnikova, O.A., Chernyak, E.I., et al., Exp. Eye Res., 2007, vol. 85, pp. 242–249.

    Article  PubMed  CAS  Google Scholar 

  9. Kopylova, L.V., Snytnikova, O.A., Chernyak, E.I., et al., Org. Biomol. Chem., 2009, vol. 7, pp. 2958–2966.

    Article  PubMed  CAS  Google Scholar 

  10. Tsentalovich, Yu.P., Snytnikova, O.A., and Sagdeev, R.Z., Usp. Khimii, 2008, vol. 77, pp. 844–853.

    Google Scholar 

  11. Snytnikova, O.A., Kopylova, L.V., Chernyak, E.I., et al., Mol. Vis., 2009, vol. 15, pp. 2780–2788.

    PubMed  CAS  Google Scholar 

  12. Rumyantseva, Yu.V., Fursova, A.Zh., Fedoseeva, L.A., and Kolosova, N.G., Biokhimiya, 2008, vol. 73, pp. 1467–1475.

    Google Scholar 

  13. Neroev, V.V., Arkhipova, M.M., Bakeeva, L.E., et al., Biokhimiya, 2008, vol. 73, pp. 1641–1654.

    Google Scholar 

  14. Skulachev, V.P., Anisimov, V.N., Antonenko, Y.N., et al., Biochim. Biophys. Acta, 2009, vol. 1787, pp. 437–461.

    Article  PubMed  CAS  Google Scholar 

  15. Stefanova, N.A., Fursova, A.Zh., Sarsenbaev, K.N., and Kolosova, N.G., J. Ethnopharmacol., 2011, vol. 138, pp. 624–632.

    Article  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. International Tomography Center of the Siberian Branch of Russian Academy of the Sciences, Novosibirsk State University, Novosibirsk, Russia

    O. A. Snytnikova, Yu. P. Tsentalovich, N. A. Stefanova, A. Zh. Fursova, R. Kaptein, R. Z. Sagdeev & N. G. Kolosova

  2. Institute of Cytology and Genetics of the Siberian Branch of Russian Academy of the Sciences, Novosibirsk, Russia

    O. A. Snytnikova, Yu. P. Tsentalovich, N. A. Stefanova, A. Zh. Fursova, R. Kaptein, R. Z. Sagdeev & N. G. Kolosova

  3. State Novosibirsk Regional Clinical Hospital Bijvoet-Center, Utrecht University, Utrecht, the Netherlands

    O. A. Snytnikova, Yu. P. Tsentalovich, N. A. Stefanova, A. Zh. Fursova, R. Kaptein, R. Z. Sagdeev & N. G. Kolosova

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  1. O. A. Snytnikova
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  2. Yu. P. Tsentalovich
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  3. N. A. Stefanova
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  4. A. Zh. Fursova
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  5. R. Kaptein
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  6. R. Z. Sagdeev
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  7. N. G. Kolosova
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Additional information

Original Russian Text © O.A. Snytnikova, Yu.P. Tsentalovich, N.A. Stefanova, A.Zh. Fursova, R. Kaptein, R.Z. Sagdeev, N.G. Kolosova, 2012, published in Doklady Akademii Nauk, 2012, Vol. 447, No. 6, pp. 678–681.

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Snytnikova, O.A., Tsentalovich, Y.P., Stefanova, N.A. et al. The therapeutic effect of mitochondria-targeted antioxidant SkQ1 and Cistanche deserticola is associated with increased levels of tryptophan and kynurenine in the rat lens. Dokl Biochem Biophys 447, 300–303 (2012). https://doi.org/10.1134/S1607672912060087

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  • DOI: https://doi.org/10.1134/S1607672912060087

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