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The role of interleukin-33 in pathogenesis of bronchial asthma. New experimental data

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Abstract

Interleukin-33 (IL-33) belongs to the IL-1 cytokine family and plays an important role in modulating immune system by inducing Th2 immune response via the ST2 membrane receptor. Epithelial cells are the major producers of IL-33. However, IL-33 is also secreted by other cells, e.g., bone marrow cells, dendritic cells, macrophages, and mast cells. IL-33 targets a broad range of cell types bearing the ST2 surface receptor. Many ST2-positive cells, such as Th2 cells, mast cells, basophils, and eosinophils, are involved in the development of allergic bronchial asthma (BA). This suggests that IL-33 directly participates in BA pathogenesis. Currently, the role of IL-33 in pathogenesis of inflammatory disorders, including BA, has been extensively investigated using clinical samples collected from patients, as well as asthma animal models. In particular, numerous studies on blocking IL-33 and its receptor by monoclonal antibodies in asthma mouse model have been performed over the last several years; IL-33-and ST2-deficient transgenic mice have also been generated. In this review, we summarized and analyzed the data on the role of IL-33 in BA pathogenesis and the prospects for creating new treatments for BA.

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Abbreviations

a.a.:

amino acid residue

BA:

bronchial asthma

BAL:

bronchoalveolar lavage

bp:

base pair

Ig:

immunoglobulin

IL:

interleukin

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Authors and Affiliations

  1. Institute of Immunology, FMBA of Russia, 115478, Moscow, Russia

    M. R. Khaitov, A. R. Gaisina, I. P. Shilovskiy, V. V. Smirnov, A. A. Nikonova & R. M. Khaitov

  2. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, 119991, Moscow, Russia

    V. V. Smirnov & G. V. Ramenskaia

  3. Mechnikov Research Institute for Vaccines and Sera, 105064, Moscow, Russia

    A. A. Nikonova

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  1. M. R. Khaitov
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  2. A. R. Gaisina
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  3. I. P. Shilovskiy
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Original Russian Text © M. R. Khaitov, A. R. Gaisina, I. P. Shilovskiy, V. V. Smirnov, G. V. Ramenskaia, A. A. Nikonova, R. M. Khaitov, 2018, published in Biokhimiya, 2018, Vol. 83, No. 1, pp. 19-33.

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Khaitov, M.R., Gaisina, A.R., Shilovskiy, I.P. et al. The role of interleukin-33 in pathogenesis of bronchial asthma. New experimental data. Biochemistry Moscow 83, 13–25 (2018). https://doi.org/10.1134/S0006297918010029

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