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Annual Review of Pharmacology and Toxicology

Volume 55, 2015

Novel Targeted Therapies for Eosinophil-Associated Diseases and Allergy

Abstract

Eosinophil-associated diseases often present with life-threatening manifestations and/or chronic organ damage. Currently available therapeutic options are limited to a few drugs that often have to be prescribed on a lifelong basis to keep eosinophil counts under control. In the past 10 years, treatment options and outcomes in patients with clonal eosinophilic and other eosinophilic disorders have improved substantially. Several new targeted therapies have emerged, addressing different aspects of eosinophil expansion and inflammation. In this review, we discuss available and currently tested agents as well as new strategies and drug targets relevant to both primary and secondary eosinophilic diseases, including allergic disorders.

Keyword(s): asthma, biologicals, chronic eosinophilic leukemia, hypereosinophilic syndrome, tyrosine kinase inhibitors
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/content/journals/10.1146/annurev-pharmtox-010814-124407
2015-01-06
2024-04-26
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Novel Targeted Therapies for Eosinophil-Associated Diseases and Allergy
Annual Review of Pharmacology and Toxicology 55, 633 (2015); https://doi.org/10.1146/annurev-pharmtox-010814-124407
/content/journals/10.1146/annurev-pharmtox-010814-124407
/content/journals/10.1146/annurev-pharmtox-010814-124407
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