Aortic Plaque in Atrial Fibrillation
Abstract
Background and Purpose—Thoracic aortic plaque identified by transesophageal echocardiography heightens the risk of stroke associated with atrial fibrillation (AF). We sought to identify the prevalence, predictors, and implications of aortic plaque in patients with nonvalvular AF.
Methods—Thoracic aortic plaque was prospectively sought in 770 persons with AF with the use of transesophageal echocardiography and classified as simple or complex on the basis of thickness ≥4 mm, ulceration, or mobility. Clinical and echocardiographic features of thromboembolism were correlated by multivariate analysis.
Results—Aortic plaque was detected in 57% of the cohort, and complex plaque was detected in 25%. Both were found more frequently in the descending than in the proximal aorta. Potentially etiologic patient characteristics independently associated with complex plaque included advanced age, history of hypertension, diabetes, and past or present tobacco use. Comorbidities associated with aortic plaque were prior thromboembolism, increased pulse pressure, ischemic heart disease, stenosis or sclerosis of the aortic valve, mitral annular calcification (>10%), elevated serum creatinine concentration, spontaneous echo contrast in the left atrium or appendage, and left atrial appendage thrombus. The prevalence of complex plaque in patients aged <70 years with <10% mitral annular calcification, without ischemic heart disease, or without pulse pressure ≥65 mm Hg was 4% (95% CI, 1% to 6%).
Conclusions—Aortic plaque is prevalent in patients with AF and is associated with atherosclerosis risk factors and with left atrial stasis or thrombosis, which are themselves independent stroke risk factors. Since the predominant location of complex plaque was in the descending aorta, the role of aortic plaque as a source of embolism in AF is uncertain.
Atherosclerotic plaque in the thoracic aorta identified by transesophageal echocardiography (TEE) is a risk factor for stroke in patients with sinus rhythm123 and raises the risk of thromboembolism associated with atrial fibrillation (AF).4 The absence of plaque in AF patients otherwise considered to be at high risk for thromboembolism was associated with a low stroke rate (1.2%/y; 95% CI, 0.2% to 8.7%) even when adequate anticoagulation was not given.4 These observations suggest that some strokes in patients with AF may arise from aortic or arterial disease rather than from the left atrium or atrial appendage56 and suggest that assessment of aortic plaque by TEE may contribute to stratification of thromboembolic risk in patients with AF.
We report the prevalence and predictors of aortic plaque and plaque with complex features in the largest cohort of AF patients prospectively evaluated for plaque. The results suggest a confluence of cardioembolic and vascular factors that contribute to thromboembolism in patients with AF.
Subjects and Methods
The Stroke Prevention in Atrial Fibrillation (SPAF) III study included a randomized trial of adjusted-dose warfarin versus low, fixed doses of warfarin plus aspirin in combination for high-risk patients (n=1044) and a separate prospective cohort study of patients at low intrinsic risk treated with aspirin alone (n=892). High-risk participants had ≥1 of the following risk factors: prior thromboembolism, systolic blood pressure >160 mm Hg, recent heart failure or fractional shortening ≤25%, or female sex and aged >75 years. Details of the design, patient selection criteria, and main results have been reported elsewhere.4789
All patients were encouraged to undergo TEE within 3 months of enrollment, and consent was obtained from 382 of 1044 high-risk patients and 404 of 892 low-risk patients. The technique for TEE acquisition and criteria for interpretation,10 interobserver reliability for assessment of variables, including aortic plaque, and TEE correlates of thromboembolic risk have also been published.411 Atherosclerotic plaque in the thoracic aorta was categorized in terms of location and morphology. The aorta was divided into ascending, transverse, and descending segments, and plaque was classified as simple (sessile) or complex on the basis of thickness ≥4 mm, ulceration, pedunculation, or mobile elements.10
Risk factors for atherosclerosis and risk factors for thromboembolism in AF patients were identified and divided into potentially etiologic patient characteristics and associated patient characteristics for atherosclerotic plaque before the start of analyses. Results for all variables evaluated are reported. Characteristics were compared between groups with Student’s t test for continuous variables and a χ2 test for categorical variables. Two series of multivariate analyses comparing any versus no plaque, and no plaque versus simple versus complex plaque, were done to identify (1) independent potentially etiologic predictors and (2) independent associated characteristics. A third series was done to identify independent etiologic and associated characteristics to derive a predictive scheme for complex plaque. Stepwise logistic regression and stepwise polychotomous logistic regression techniques were used (likelihood ratio test). The 75th percentile was used as the cut point for any continuous variable in the predictive scheme. Statistical significance was accepted at the 0.05 level, and all tests were 2-sided.
Results
Among 786 completed TEE studies, 770 yielded images of the thoracic aorta sufficient to assess or exclude atherosclerotic plaque. Comparisons of patients and characteristics in this TEE population versus those who did not undergo TEE are presented in Table 1. Very small but highly significant differences in patient characteristics were noted. Plaque was detected in 57% of patients, and plaque with features classified as complex was detected in 25% of patients. Plaque was more prevalent in the descending aorta (simple in 30% and complex in 21%) than in the segments proximal to the origins of the cerebral arteries (simple in 21% and complex in 12%) (Figure 1). During a total of 1254 patient-years of follow-up after TEE, no peripheral embolic events occurred, while 16 strokes occurred in persons with complex plaque, 16 strokes in those with simple plaque, and 10 strokes in those with absent plaque.
Patients at high risk of thromboembolism on the basis of clinical and precordial echocardiographic criteria were more likely to have aortic plaque than low-risk patients (complex in 35% versus 15%; P<0.001). Univariate variables potentially related to aortic plaque are listed in Table 2. Multivariate analysis identified age as an independent, potentially etiologic predictor of simple and complex plaque, while tobacco smoking, hypertension, and diabetes were independently associated with complex plaque alone (Table 3). Complex plaque was not related to sex, random serum cholesterol levels, or fibrinogen. Of the associated patient characteristics, increased pulse pressure, aortic valve disease, and left atrial spontaneous echo contrast and thrombus were associated with both simple and complex plaque (Table 3). Prior thromboembolism (relative risk, 2.9; 95% CI, 1.9 to 4.6; P<0.001) and mitral annular calcification >10% (relative risk, 3.3; 95% CI, 1.8 to 6.0; P<0.001) were strongly associated with complex plaque alone.
Multivariate analysis of both etiologic features and comorbidities (Table 4) confirmed the strong association of tobacco smoking, prior thromboembolism, and mitral annular calcification >10% with complex aortic plaque (all P<0.001). Although the prevalence of plaque varied by segment, these predictors of simple and complex plaque were confirmed at all sites. The prevalence of complex plaque was 4% (95% CI, 1% to 6%) among patients <70 years of age without the following: ischemic heart disease, pulse pressure ≥65 mm Hg, or mitral annular calcification >10% (31% of the cohort). Current tobacco smoking in a patient with any of these 4 predictive characteristics raised the prevalence of complex plaque to >50% to approach that associated with prior thromboembolism (Figure 2). Increased left ventricular mass appeared associated with reduced plaque, but this finding was restricted to persons aged >70 years who lacked other characteristics associated with aortic plaque.
Discussion
Atherosclerotic plaque in the thoracic aorta identified by TEE was first linked with clinical thromboembolism in 1990.12 The magnitude of stroke risk associated with this ultrasound finding (≈12%/y) can be estimated only within broad confidence limits, however, both in patients with AF11 and in those without this dysrhythmia.131415 The sonographic morphology of these atherosclerotic lesions is related to the risk of stroke13 in that patients with complex plaques are at almost twice the risk of those without this configuration. In patients with AF at high risk of thromboembolism who have complex aortic plaque, the rate of stroke among those treated by anticoagulation with adjusted-dose warfarin was one fourth the rate seen with a low-intensity combination of warfarin and aspirin.4 While this reduction in stroke among anticoagulated AF patients may have been due to disappearance of thrombus in the left atrial appendage,16 the rate of thromboembolism was also low (<2% annually; 95% CI, 0.2% to 8.7%/y) in similar high-risk AF patients without plaque who were not adequately anticoagulated.4 This implies a role but does not define a site for cardiac or arterial thrombosis in the risk of stroke associated with complex aortic plaque in the AF population.
Classification, Prevalence, and Location of Aortic Plaque
Complex aortic plaques are so designated by thickness or in terms of surface abnormalities. Mobile components are usually thrombi1718 that vary with time and location. Aortic plaque was found proximal to the left subclavian artery on postmortem examination in 60% of elderly stroke victims,19 and despite a sonographic “blind spot” in the upper ascending aorta, this was almost the same prevalence at which it was detected by TEE in patients with nonfatal stroke (55% to 57%).13 Atheromatous lesions are more common in the descending versus ascending or transverse arch portions of the thoracic aorta. Amarenco et al1 found plaque in the descending aortas of >90% of patients with prior stroke; the prevalence of complex plaque in this segment was 24%. The recurrent stroke rate in patients with complex lesions in the proximal aorta was >10%/y, and vascular events in these patients (stroke, myocardial infarction, peripheral embolism, death from vascular cause) occurred at approximately twice the rate of recurrent embolism.1415 Among patients undergoing TEE during coronary bypass or valvular heart surgery, >50% displayed plaque in the aorta, ≈33% in the proximal and transverse segments, and >40% in the descending limb. Complex lesions occurred in 16%, and perioperative stroke rates correlated with the prevalence of complex plaque in the descending aorta.2021 The prevalence of complex plaque in the ascending and transverse aortic segments in our AF patients, 12%, falls near the lower end of the range described in studies of stroke patients (14% to 42%),132223 and parallels thromboembolic risk defined on the basis of clinical criteria. Complex plaque at any site was detected in 15% of low-risk patients and 35% of high-risk patients, similar to the prevalence reported in patients with AF referred for TEE (half of whom had prior clinical thromboembolism) (Table 5).242526 In contrast, carotid artery stenosis has been reported less frequently in AF patients (8%; range, 4% to 17%).27
Predictors of Aortic Plaque
In unselected stroke patients, complex plaque in the ascending or transverse segments was associated with peripheral and carotid arterial disease as well as with age, tobacco smoking, and diabetes.314 In patients undergoing cardiac surgery because of ischemic or valvular disease, serum cholesterol, plasma fibrinogen, and small body mass were additional predictors of complex plaque.2128 In our broad population of AF patients, we determined that age, tobacco smoking, pulse pressure, and thrombus in the left atrial appendage were independently associated with plaque, both simple and complex. Additional patient features that predicted complex plaque included prior thromboembolism, ischemic heart disease, diabetes, and moderate to severe mitral annular calcification, all variables independently associated with stroke in patients with or without AF.4293031 Calcific disease of the aortic valve was also independently associated. Aortic valve disease has previously been linked to atherosclerotic risk factors, but not stroke risk.32 AF patients aged >70 years with ischemic heart disease, mitral annular calcification >10%, and arterial pulse pressure ≥65 mm Hg were most likely to display complex aortic plaque.
Although hypertension and increased pulse pressure were strongly associated with complex aortic plaque, left ventricular mass was inversely related in older patients without other characteristics associated with complex plaque. This paradox is consistent with observations at autopsy. In victims of cryptogenic cerebral infarction,19 cardiac mass was lower (388±109 versus 427±108 g; P=0.08) and proximal aortic plaque was more prevalent (61% versus 22%; odds ratio, 5.7; 95% CI, 2.5 to 13.6) than in those in whom an embolic source was identified. An inverse relationship between aortic plaque and cardiac mass might mean that AF patients who adapt to aging with development of myocardial hypertrophy have a reduced tendency to develop aortic atherosclerosis versus those who do not develop hypertrophy. Opposite responses in cardiac muscle and arterial wall might reflect genetically mediated adaptive differences, which are now under active investigation.33343536
Study Limitations
TEE was performed in willing patients at entry into this clinical trial, but fewer than 50% of the total patients underwent TEE, raising the possibility that our findings may not represent either the SPAF III population overall or an AF population in general. The SPAF III TEE population is not dissimilar to the Atrial Fibrillation Investigators population of 4253 AF patients in terms of mean age (69 years), history of hypertension (45%), angina (23%), or congestive heart failure (20%).37 These data suggest that the SPAF III TEE population is similar in most respects to prior AF clinical trial populations, who are, admittedly, selected populations.38
The existence of a sonographic blind spot in the aorta (upper ascending aorta) is an additional limitation in an analysis that seeks to define plaque prevalence and describe a source of embolism. Finally, the potentially etiologic and associated variables selected for analysis were based on current concepts of pathogenesis. Chance association of selected variables with plaque or failure of selection of relevant variables for analysis cannot be excluded.
Implications of Aortic Plaque in AF
Although the prevalence of complex aortic plaque in patients with AF raises the possibility that plaque-associated thrombus may be a direct cause of embolism in AF, such a mechanism has not been proven. In prior studies in which most plaques were found in the proximal aorta, both cerebral and peripheral emboli occurred, while in our patients with complex plaque limited to the descending aorta, clinical ischemic events exclusively involved the central nervous system (Figure 3).1314153940 The paucity of peripheral ischemic events in our treated patients suggests that plaque-related embolism is not the dominant mechanism of thromboembolism in AF. Endocardial and left atrial abnormalities (thrombus, spontaneous echo contrast, and reduced appendage flow velocity) were more prevalent in patients with complex aortic plaque than in those without plaque. The rate of thromboembolism was low among patients without plaque treated with the relatively ineffective combination of low-dose warfarin plus aspirin (1.2%/y; 95% CI, 0.2% to 8.7%).4 In contrast, those with complex plaque had a high risk of stroke (16%/y; 95% CI, 8.7% to 28%), unless treated more intensively with adjusted-dose warfarin (4.0%/y; 95% CI, 1.3% to 12%).4 This association of complex plaque with thromboembolic risk may be mediated by left atrial or endocardial abnormalities in patients with AF.
Patients Who Underwent TEE (n=786) | Patients Who Did Not Undergo TEE (n=1150) | P | |
---|---|---|---|
Mean±SD age, y | 69±9 | 70±10 | <0.001 |
Aged >75 y, % | 23 | 32 | <0.001 |
Female, % | 24 | 36 | <0.001 |
Female and aged >75 y, % | 8 | 16 | <0.001 |
History of hypertension, % | 54 | 60 | 0.009 |
Systolic BP >160 mm Hg at entry, % | 14 | 19 | 0.005 |
Previous thromboembolism, % | 19 | 21 | |
Diabetes mellitus, % | 15 | 16 | |
History of congestive heart failure, % | 25 | 30 | 0.04 |
Recent congestive heart failure, % | 13 | 17 | |
Ischemic heart disease, % | 26 | 24 | |
Characterization of AF, % | |||
Onset >1 y | 73 | 74 | |
Intermittent | 19 | 23 | 0.03 |
Transthoracic echocardiography findings | |||
Mean±SD fractional shortening | 34±9 | 34±10 | |
Fractional shortening ≤25%, % | 15 | 17 | |
Moderately/severely abnormal LV function, % | 12 | 15 | |
Mean±SD LA size by M-mode, cm | 4.8±0.7 | 4.7±0.8 | 0.006 |
Left atrium >50 mm, % | 34 | 28 | 0.02 |
No Plaque (n=334) | Any Plaque (n=436) | Simple Plaque Only (n=243) | Complex Plaque (n=193) | |
---|---|---|---|---|
Potentially etiologic variables | ||||
Mean age, y | 66 | >713 | 703 | 723 |
Male, % | 75 | 76 | 77 | 76 |
Hormone use, % | 9 | 6 | 6 | 5 |
Ever smoker, % | 57 | 643 | 63 | 663 |
Current smoker, % | 8 | 9 | 7 | 11 |
Alcohol use, % | 16 | 19 | 20 | 18 |
History of hypertension, % | 48 | 603 | 55 | 663 |
Diabetes mellitus, % | 12 | 17 | 15 | 203 |
Mean random cholesterol, mmol/L1 | 5.1 | 5.3 | 5.3 | 5.2 |
Mean fibrinogen, g/L | 3.2 | 3.2 | 3.1 | 3.3 |
Associated variables | ||||
Prior thromboembolism, % | 13 | 243 | 15 | 353 |
Carotid bruit or endarterectomy, % | 3 | 93 | 5 | 133 |
Mean systolic BP, mm Hg | 131 | 1383 | 1363 | 1423 |
Mean pulse pressure, mm Hg | 53 | 603 | 583 | 633 |
Ischemic heart disease, % | 18 | 333 | 263 | 413 |
Congestive heart failure, % | 24 | 27 | 21 | 353 |
Peripheral vascular disease (%) | 5 | 103 | 5 | 173 |
Mean serum creatinine, μmol/L2 | 99 | 1063 | 1033 | 1083 |
Moderate/severe LV dysfunction, % | 12 | 12 | 9 | 16 |
Mean LV mass, g | 272 | 263 | 259 | 269 |
Mean LV WMSI | 1.2 | 1.2 | 1.2 | 1.3 |
Mean fractional shortening, % | 34 | 35 | 35 | 35 |
MAC>10% | 4 | 113 | 7 | 173 |
Aortic stenosis/sclerosis, % | 38 | 603 | 563 | 643 |
Patent foramen ovale, % | 17 | 17 | 17 | 17 |
Mean LA diameter, M-mode, mm | 47 | 48 | 48 | 48 |
LA/LAA SEC, % | 45 | 633 | 643 | 623 |
LA/LAA dense SEC, % | 9 | 173 | 163 | 173 |
LA/LAA thrombus, % | 3 | 103 | 93 | 123 |
Mean peak antegrade LAA flow velocity, cm/s | 38 | 353 | 34 | 35 |
Any Plaque vs None1 | Simple Plaque vs None2 | Complex Plaque vs None2 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RR | 95% CI | P | RR | 95% CI | P | RR | 95% CI | P | |||||||
Etiologic features only | |||||||||||||||
Age, per 10-y increase | 2.0 | 1.7, 2.4 | <0.001 | 1.6 | 1.3, 2.0 | <0.001 | 2.8 | 2.2, 3.6 | <0.001 | ||||||
History of hypertension | 1.4 | 1.1, 1.9 | 0.02 | … | … | NS | 1.7 | 1.2, 2.5 | 0.003 | ||||||
Diabetes mellitus | 1.5 | 1.0, 2.4 | 0.05 | … | … | NS | 1.7 | 1.1, 2.6 | 0.03 | ||||||
Tobacco use | 0.009 | 0.09 | <0.001 | ||||||||||||
Former smoker | 1.5 | 1.1, 2.0 | … | 1.3 | 1.0, 1.9 | … | 1.7 | 1.1, 2.5 | … | ||||||
Current smoker | 2.2 | 1.2, 3.9 | … | … | 3.5 | 1.8, 6.9 | … | ||||||||
Associated features only | |||||||||||||||
Prior thromboembolism | 1.6 | 1.0, 2.5 | 0.04 | … | … | NS | 2.9 | 1.9, 4.6 | <0.001 | ||||||
Pulse pressure, per 10 mm Hg | 1.2 | 1.1, 1.4 | <0.001 | 1.2 | 1.0, 1.3 | 0.006 | 1.4 | 1.2, 1.5 | <0.001 | ||||||
Ischemic heart disease | 1.7 | 1.1, 2.6 | 0.009 | … | … | NS | 2.1 | 1.4, 3.3 | <0.001 | ||||||
AV stenosis/sclerosis | 1.9 | 1.4, 2.7 | <0.001 | 1.9 | 1.3, 2.7 | <0.001 | 2.3 | 1.5, 3.6 | <0.001 | ||||||
MAC>10% | 2.2 | 1.1, 4.4 | 0.02 | … | … | NS | 3.3 | 1.8, 6.0 | <0.001 | ||||||
LV mass, per 100 g | 0.7 | 0.6, 0.9 | <0.001 | 0.8 | 0.6, 0.9 | 0.009 | 0.7 | 0.6, 0.9 | 0.004 | ||||||
Spontaneous echo contrast | 1.8 | 1.3, 2.5 | <0.001 | 2.0 | 1.4, 3.0 | <0.001 | 1.6 | 1.0, 2.4 | 0.05 | ||||||
LA/LAA thrombus | 2.5 | 1.2, 5.4 | 0.01 | 2.3 | 1.0, 5.1 | 0.04 | 2.9 | 1.2, 6.8 | 0.01 | ||||||
Creatinine, per 88.7 μmol/L | 1.9 | 1.1, 3.5 | 0.03 | … | … | NS | 1.9 | 1.0, 3.6 | 0.05 |
Any Plaque vs None1 | Simple Plaque vs None2 | Complex Plaque vs None2 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RR | 95% CI | P | RR | 95% CI | P | RR | 95% CI | P | |||||||
Age, per 10-y increase | 1.5 | 1.2, 1.9 | <0.001 | 1.3 | 1.1, 1.7 | 0.009 | 2.1 | 1.5, 2.8 | <0.001 | ||||||
Tobacco use | 0.03 | 0.06 | 0.001 | ||||||||||||
Former smoker | 1.5 | 1.0, 2.1 | 1.4 | 1.0, 2.1 | 1.6 | 1.0, 2.6 | |||||||||
Current smoker | 2.0 | 1.0, 3.7 | 4.1 | 1.9, 8.8 | |||||||||||
Diabetes mellitus | … | … | NS | … | … | NS | 1.7 | 1.0, 2.8 | 0.04 | ||||||
Prior thromboembolism | … | … | NS | … | … | NS | 2.8 | 1.8, 4.4 | <0.001 | ||||||
Pulse pressure, per 10 mm Hg | 1.2 | 1.1, 1.3 | <0.001 | 1.1 | 1.0, 1.3 | 0.04 | 1.3 | 1.1, 1.5 | <0.001 | ||||||
Ischemic heart disease | 1.6 | 1.1, 2.5 | 0.02 | … | … | NS | 2.0 | 1.3, 3.1 | 0.002 | ||||||
AV stenosis/sclerosis | 1.7 | 1.2, 2.4 | 0.003 | 1.6 | 1.1, 2.4 | 0.01 | 1.9 | 1.2, 2.9 | 0.006 | ||||||
MAC>10% | 1.9 | 1.0, 3.9 | 0.05 | … | … | NS | 2.9 | 1.5, 5.4 | 0.001 | ||||||
LV mass, per 100 g | 0.8 | 0.6, 0.9 | 0.004 | 0.8 | 0.6, 1.0 | 0.01 | 0.8 | 0.6, 1.0 | 0.03 | ||||||
Spontaneous echo contrast | 1.7 | 1.2, 2.4 | 0.002 | 1.7 | 1.2, 2.4 | 0.003 | … | … | NS | ||||||
LA/LAA thrombus | 2.7 | 1.3, 5.9 | 0.006 | 2.6 | 1.2, 5.9 | 0.02 | 3.7 | 1.6, 8.6 | 0.002 |
n | Age, y | Prior TEE, % | LA Thrombus, % | LA SEC, % | Moderate/Severe LV Dysfunction, % | Any Plaque, % | Complex Plaque, % | |
---|---|---|---|---|---|---|---|---|
Leung et al241 | 272 | 68 | 41 | 7 | 59 | 15 | 46 | 10 |
Mitusch et al251 | 107 | 68 | 54 | 26 | 67 | 15 | 56 | 15 |
Pozzoli et al2612 | 101 | 61 | 47 | 22 | 44 | … | … | 18 |
SPAF III TEE1 | 770 | 69 | 19 | 7 | 55 | 12 | 57 | 25 |
This study was supported by grants R01-NS-33551 and R01-NS-24224 from the National Institute of Neurological Disorders and Stroke (National Institutes of Health).
Footnotes
References
- 1 Amarenco P, Cohen A, Tzourio C, Bertrand B, Hommel M, Besson G, Chauvel C, Touboul PJ, Bousser MG. Atherosclerotic disease of the aortic arch and the risk of ischemic stroke. N Engl J Med.1994; 331:1474–1479.CrossrefMedlineGoogle Scholar
- 2 Amarenco P, Cohen A, Hommel M, Bousser M. Atherosclerotic disease of the aortic arch and the risk of ischemic stroke. N Engl J Med.1995; 332:1237–1238.CrossrefGoogle Scholar
- 3 Jones EF, Kalman JM, Calafiore P, Tonkin AM, Donnan GA. Proximal aortic atheroma: an independent risk factor for cerebral ischemia. Stroke.1995; 26:218–224.MedlineGoogle Scholar
- 4 Stroke Prevention in Atrial Fibrillation Investigators Committee on Echocardiography. Transesophageal echocardiographic correlates of thromboembolism in high-risk patients with nonvalvular atrial fibrillation. Ann Intern Med.1998; 128:639–647.CrossrefMedlineGoogle Scholar
- 5 Miller VT, Rothrock JF, Pearce LA, Feinberg WM, Hart RG, Anderson DC, on behalf of the Stroke Prevention in Atrial Fibrillation investigators. Ischemic stroke in patients with atrial fibrillation: effect of aspirin according to stroke mechanism. Neurology.1993; 43:32–36.CrossrefMedlineGoogle Scholar
- 6 Manning WJ, Douglas PS. Transesophageal echocardiography and atrial fibrillation: added value or expensive toy? Ann Intern Med.1998; 128:685–687.CrossrefMedlineGoogle Scholar
- 7 Stroke Prevention in Atrial Fibrillation Investigators. The Stroke Prevention in Atrial Fibrillation III randomized clinical trial: background, design and patient characteristics of the Stroke Prevention in Atrial Fibrillation III study. J Stroke Cerebrovasc Dis.1997; 6:341–353.CrossrefMedlineGoogle Scholar
- 8 Stroke Prevention in Atrial Fibrillation Investigators. Adjusted-dose warfarin versus low-intensity, fixed-dose warfarin plus aspirin for high-risk patients with atrial fibrillation: Stroke Prevention in Atrial Fibrillation III randomised clinical trial. Lancet.1996; 348:633–638.CrossrefMedlineGoogle Scholar
- 9 Stroke Prevention in Atrial Fibrillation III Study Investigators. Patients with nonvalvular atrial fibrillation at low risk of stroke during treatment with aspirin: Stroke Prevention in Atrial Fibrillation Study. JAMA.1998; 279:1273–1277.CrossrefMedlineGoogle Scholar
- 10 Stroke Prevention in Atrial Fibrillation Investigators Committee on Echocardiography. Transesophageal echocardiography in atrial fibrillation: standards for acquisition and interpretation and assessment of interobserver variability. J Am Soc Echocardiogr.1996; 9:556–566.MedlineGoogle Scholar
- 11 Zabalgoitia M, Halperin JL, Pearce LA, Blackshear JL, Asinger RW, Hart RG, for the Stroke Prevention in Atrial Fibrillation III Investigators. Transesophageal echocardiographic correlates of clinical risk of thromboembolism in nonvalvular atrial fibrillation. J Am Coll Cardiol.1998; 31:1622–1626.CrossrefMedlineGoogle Scholar
- 12 Tunick PA, Kronzon I. Protruding atherosclerotic plaque in the aortic arch of patients with systemic embolization: a new finding seen by transesophageal echocardiography. Am Heart J.1990; 120:658–660.CrossrefMedlineGoogle Scholar
- 13 Tunick PA, Rosenzweig BP, Katz ES, Freedberg RS, Perez JL, Kronzon I. High risk for vascular events in patients with protruding aortic atheromas: a prospective study. J Am Coll Cardiol.1994; 23:1085–1090.CrossrefMedlineGoogle Scholar
- 14 The French Study of Aortic Plaques in Stroke Group. Atherosclerotic disease of the aortic arch as a risk factor for recurrent ischemic stroke. N Engl J Med.1996; 334:1216–1221.CrossrefMedlineGoogle Scholar
- 15 Mitusch R, Doherty C, Wucherpfennig H, Memmesheimer C, Tepe C, Stierle U, Kessler C, Sheikhzadeh A. Vascular events during follow-up in patients with aortic arch atherosclerosis. Stroke.1997; 28:36–39.CrossrefMedlineGoogle Scholar
- 16 Collins LJ, Silverman DI, Douglas PS, Manning WJ. Cardioversion of nonrheumatic atrial fibrillation: reduced thromboembolic complications with 4 weeks of precardioversion anticoagulation are related to atrial thrombus resolution. Circulation.1995; 92:160–163.CrossrefMedlineGoogle Scholar
- 17 Kronzon I, Tunick PA. Atheromatous disease of the thoracic aorta: pathologic and clinical implications. Ann Intern Med.1997; 126:629–637.CrossrefMedlineGoogle Scholar
- 18 Vaduganathan P, Ewton A, Nagueh SF, Weilbaecher DG, Safi HJ, Zoghbi WA. Pathologic correlates of aortic plaques, thrombi and mobile “aortic debris” imaged in vivo with transesophageal echocardiography. J Am Coll Cardiol.1997; 30:357–363.CrossrefMedlineGoogle Scholar
- 19 Amarenco P, Duyckaerts C, Tzourio C, Henin D, Bousser MG, Hauw JJ. The prevalence of ulcerated plaques in the aortic arch in patients with stroke. N Engl J Med.1992; 326:221–225.CrossrefMedlineGoogle Scholar
- 20 Dávila-Román VG, Barzilai B, Wareing TH, Murphy SF, Schechtman KB, Kouchoukos NT. Atherosclerosis of the ascending aorta: prevalence and role as an independent predictor of cerebrovascular events in cardiac patients. Stroke.1994; 25:2010–2016.CrossrefMedlineGoogle Scholar
- 21 Hartman GS, Yao FS, Bruefach M III, Barbut D, Peterson JC, Purcell MH, Charlson ME, Gold JP, Thomas SJ, Szatrowski TP. Severity of aortic atheromatous disease diagnosed by transesophageal echocardiography predicts stroke and other outcomes associated with coronary artery surgery: a prospective study. Anesth Analg.1996; 83:701–708.CrossrefMedlineGoogle Scholar
- 22 Toyoda K, Yasaka M, Nagata S, Yamaguchi T. Aortogenic embolic stroke: a transesophageal echocardiographic approach. Stroke.1992; 23:1056–1061.CrossrefMedlineGoogle Scholar
- 23 Di Tullio MR, Sacco RL, Gersony D, Nayak H, Weslow RG, Kargman DE, Homma S. Aortic atheromas and acute ischemic stroke: a transesophageal echocardiographic study in an ethnically mixed population. Neurology.1996; 46:1560–1566.CrossrefMedlineGoogle Scholar
- 24 Leung DY, Black IW, Cranney GB, Hopkins AP, Walsh WF. Prognostic implications of left atrial spontaneous echo contrast in nonvalvular atrial fibrillation. J Am Coll Cardiol.1994; 24:755–762.CrossrefMedlineGoogle Scholar
- 25 Mitusch R, Lange V, Stierle U, Maurer B, Sheikhzadeh A. Transesophageal echocardiographic determinants of embolism in nonrheumatic atrial fibrillation. Int J Card Imaging.1995; 11:27–34.CrossrefMedlineGoogle Scholar
- 26 Pozzoli M, Tramarin R, Gibellini R, Ferrari-Bardile A, Capomolla S, Forni G, Sanarico M, Cobelli F. Cardiac and vascular sources of peripheral thromboembolism in patients with atrial fibrillation: a combined transesophageal and vascular ultrasonographic study. G Ital Cardiol.1995; 25:301–314.MedlineGoogle Scholar
- 27 Kanter MC, Tegeler CH, Pearce LA, Weinberger J, Feinberg WM, Anderson DC, Gomez CR, Rothrock JF, Helgason CM, Hart RG. Carotid stenosis in patients with atrial fibrillation: prevalence, risk factors, and relationship to stroke in the Stroke Prevention in Atrial Fibrillation Study. Arch Intern Med.1994; 154:1372–1377.CrossrefMedlineGoogle Scholar
- 28 Tribouilloy C, Peltier M, Colas L, Senni M, Ganry O, Rey JL, Lesbre JP. Fibrinogen is an independent marker for thoracic aortic atherosclerosis. Am J Cardiol.1998; 81:321–326.CrossrefMedlineGoogle Scholar
- 29 Aronow WS, Ahn C, Kronzon I, Gutstein H. Association of mitral annular calcium with new thromboembolic stroke at 44-month follow-up of 2,148 persons, mean age 81 years. Am J Cardiol.1998; 81:105–106.CrossrefMedlineGoogle Scholar
- 30 Atrial Fibrillation Investigators. Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation: analysis of pooled data from five randomized controlled trials. Arch Intern Med.1994; 154:1449–1457.CrossrefMedlineGoogle Scholar
- 31 Adler Y, Shohat-Zabarski R, Vaturi M, Shapira Y, Ehrlich S, Jortner R, Assali A, Zonshin A, Sagie A. Association between mitral annular calcium and aortic atheroma as detected by transesophageal echocardiographic study. Am J Cardiol.1998; 81:784–786.CrossrefMedlineGoogle Scholar
- 32 Boon A, Lodder J, Cheriex E, Kessels F. Risk of stroke in a cohort of 815 patients with calcification of the aortic valve with or without stenosis. Stroke.1996; 27:847–851.CrossrefMedlineGoogle Scholar
- 33 Lehmann ED, Hopkins KD, Jones RL, Rudd AG, Gosling RG. Aortic distensibility in patients with cerebrovascular disease. Clin Sci (Colch).1995; 89:247–253.CrossrefGoogle Scholar
- 34 Montgomery HE, Clarkson P, Dollery CM, Prasad K, Losi MA, Hemingway H, Statters D, Jubb M, Girvain M, Varnava A, World M, Deanfield J, Talmud P, McEwan JR, McKenna WJ, Humphries S. Association of angiotensin-converting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training. Circulation.1997; 96:741–747.CrossrefMedlineGoogle Scholar
- 35 Schunkert H, Hense HW, Holmer SR, Stender M, Perz S, Keil U, Lorell BH, Riegger GA. Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy. N Engl J Med.1994; 330:1634–1638.CrossrefMedlineGoogle Scholar
- 36 Benetos A, Gautier S, Ricard S, Topouchian J, Asmar R, Poirier O, Larosa E, Guize L, Safar M, Soubrier F, Cambien F. Influence of angiotensin-converting enzyme and angiotensin II type 1 receptor gene polymorphisms on aortic stiffness in normotensive and hypertensive patients. Circulation.1996; 94:698–703.CrossrefMedlineGoogle Scholar
- 37 Atrial Fibrillation Investigators. Echocardiographic predictors of stroke in patients with atrial fibrillation: a prospective study of 1066 patients from 3 clinical trials. Arch Intern Med.1998; 158:1316–1320.CrossrefMedlineGoogle Scholar
- 38 Blackshear JL, Kopecky SL, Litin SC, Safford RE, Hammill SC. Management of atrial fibrillation in adults: prevention of thromboembolism and symptomatic treatment. Mayo Clin Proc.1996; 71:150–160.CrossrefMedlineGoogle Scholar
- 39 Tunick PA, Perez JL, Kronzon I. Protruding atheromas in the thoracic aorta and systemic embolization. Ann Intern Med.1991; 115:423–427.CrossrefMedlineGoogle Scholar
- 40 Karalis DG, Chandrasekaran K, Victor MF, Ross JJ Jr, Mintz GS. Recognition and embolic potential of intraaortic atherosclerotic debris. J Am Coll Cardiol.1991; 17:73–78.CrossrefMedlineGoogle Scholar
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