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High-Risk Human Papillomavirus DNA Test: Could It Be Useful in Low-Grade Cervical Lesion Triage? Five-Year Follow-Up

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Abstract

We conducted a retrospective, observational study in order to evaluate the role of high-risk human papillomavirus (hrHPV)-DNA test in patients with first diagnosis of low-grade squamous intraepithelial lesions (L-SILs).Patients were divided into group A, annual Papanicolaou test and hrHPV-DNA tests (167 patients) and group B, immediate colposcopy, followed by annual papanicolaou test and hrHPV-DNA tests (164 patients). We assessed sensitivity, specificity, negative predictive value (NPV), positive predictive value, positive–negative likelihood ratio of hrHPV-DNA test, and 5-year relative risk of cervical intraepithelial neoplasia grade 2 in hrHPV-DNA+. Colposcopy is still considered the best choice for women with L-SIL and hrHPV-DNA+ test. High sensitivity and NPV of hrHPV-DNA test permit to use it in the follow-up of L-SIL with a HPV-negative status, without necessity of referring to colposcopy.

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Authors and Affiliations

  1. Department of Woman and Child Health, University of Padua, Via Giustiniani 3, 35128, Padua, Italy

    Carlo Saccardi MD, PhD, Salvatore Gizzo MD, Marco Noventa MD, Omar Anis MD, Stefania Di Gangi MD, Donato D’Antona MD & Giovanni Battista Nardelli MD

  2. Department of Surgical Sciences, University of Parma, Parma, Italy

    Tito Silvio Patrelli MD

Authors
  1. Carlo Saccardi MD, PhD
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  2. Salvatore Gizzo MD
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  3. Marco Noventa MD
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  4. Omar Anis MD
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  5. Stefania Di Gangi MD
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  6. Tito Silvio Patrelli MD
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  7. Donato D’Antona MD
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  8. Giovanni Battista Nardelli MD
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Correspondence to Salvatore Gizzo MD.

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Saccardi, C., Gizzo, S., Noventa, M. et al. High-Risk Human Papillomavirus DNA Test: Could It Be Useful in Low-Grade Cervical Lesion Triage? Five-Year Follow-Up. Reprod. Sci. 21, 198–203 (2014). https://doi.org/10.1177/1933719113492214

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  • DOI: https://doi.org/10.1177/1933719113492214

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