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Early-Pregnancy Changes in Maternal Lipid Profile in Women With Recurrent Preeclampsia and Previously Preeclamptic Women With Normal Next Pregnancy

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Abstract

Objective

To evaluate early-pregnancy changes in lipid profile in recurrent preeclampsia.

Methods

In this retrospective observational study, blood samples were obtained from 41 normotensive women with a history of early-onset preeclampsia preconceptionally and at 12 and 16 weeks in the next pregnancy. We assessed triglycerides (TGs), total cholesterol (TC), and high- and low-density lipoprotein cholesterol (HDL-C and LDL-C, respectively). We analyzed differences in longitudinal patterns between normal and recurrent preeclamptic next pregnancy using mixed-design repeated measurements analysis of covariance (ANCOVA).

Results

Eleven (28%) women developed recurrent preeclampsia. Eighteen (45%) women had a normal pregnancy. In normal pregnancy, LDL-C declines transiently in the first trimester (P < .01). In women who develop recurrent preeclampsia later on this decline was absent. Moreover, from 12 weeks onward the elevating levels of HDL-C stagnates in women who subsequently develop recurrent preeclampsia (P = .02).

Conclusion

These observations point to an abnormal early adaptation of lipid metabolism to pregnancy preceding clinical manifestation of preeclampsia.

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Authors and Affiliations

  1. Department of Internal Medicine, Maastricht University Medical Centre, PO Box 5800, Maastricht, AZ, 6202, The Netherlands

    Simone Sep PhD

  2. Department of Epidemiology, Maastricht University Medical Centre, Maastricht, The Netherlands

    Simone Sep PhD & Luc Smits PhD

  3. Department of Obstetrics and Gynecology, Maastricht University Medical Centre, Maastricht, The Netherlands

    Carmen Rijvers MD & Louis Peeters MD, PhD

  4. Department of Physiology, Maastricht University Medical Centre, Maastricht, The Netherlands

    Marc van Bilsen PhD

  5. Department of Clinical Chemistry, Maastricht University Medical Centre, Maastricht, The Netherlands

    Otto Bekers PhD

Authors
  1. Simone Sep PhD
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  2. Carmen Rijvers MD
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  3. Luc Smits PhD
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  4. Marc van Bilsen PhD
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  5. Otto Bekers PhD
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  6. Louis Peeters MD, PhD
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Correspondence to Simone Sep PhD.

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Sep, S., Rijvers, C., Smits, L. et al. Early-Pregnancy Changes in Maternal Lipid Profile in Women With Recurrent Preeclampsia and Previously Preeclamptic Women With Normal Next Pregnancy. Reprod. Sci. 18, 998–1004 (2011). https://doi.org/10.1177/1933719111401665

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  • DOI: https://doi.org/10.1177/1933719111401665

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