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A Clinical and Pathologic Comparison Between Stage-Matched Endometrial Intraepithelial Carcinoma and Uterine Serous Carcinoma

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Abstract

Endometrial intraepithelial carcinoma (EIC) is a rare pathologic variant of uterine serous carcinoma (USC). Our aim is to distinguish patterns of clinic—pathologic outcomes in patients with EIC and USC for disease limited to the endometrium (stage 1A) as well as with distant metastasis (stage 4B). Surgically staged patients were retrospectively identified and relevant variables were extracted and compared. Kaplan-Meier was used to generate the survival data. More USC (n = 29) exhibited lymphovascular invasion (stage 4, P = .01) and expressed higher levels of estrogen receptor-α than EIC (P = .0009 and .063 for stages 1 and 4, respectively). The survival is comparable, with 1 recurrence in each group for stage 1A disease. For stage 4 EIC and USC, the progression-free survival (14 vs10 months) and overall survival (19 vs 20 months) are similar to what is previously published. In conclusion, EIC, whether limited to the endometrium, or widely metastatic, imparts similar outcomes and should be treated comparably with stage-matched USC.

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Authors and Affiliations

  1. Division of Gynecology Oncology, Department of Obstetrics & Gynecology and Women’s Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA

    June Y. Hou MD

  2. Department of Obstetrics & Gynecology and Women’s Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA

    Thomas C. McAndrew MS & Gary L. Goldberg MD

  3. Department of Pathology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA

    Kathleen Whitney MD

  4. Department of Obstetrics, Gynecology, and Reproductive Biology, Danbury Hospital, Danbury, CT, USA

    Shohreh Shahabi MD

Authors
  1. June Y. Hou MD
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  2. Thomas C. McAndrew MS
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  3. Gary L. Goldberg MD
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  4. Kathleen Whitney MD
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  5. Shohreh Shahabi MD
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Correspondence to Shohreh Shahabi MD.

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Hou, J.Y., McAndrew, T.C., Goldberg, G.L. et al. A Clinical and Pathologic Comparison Between Stage-Matched Endometrial Intraepithelial Carcinoma and Uterine Serous Carcinoma. Reprod. Sci. 21, 532–537 (2014). https://doi.org/10.1177/1933719113503414

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