Abstract
The purpose of this investigation was to determine the relationship between dose and the distribution of salicylate in the body. The apparent volume of distribution was determined from the concentration of salicylate in plasma or serum at various times after salicylate ingestion and from the amount of drug remaining in the body at these times as assessed from urinary excretion data. These studies were carried out on eleven children, 4 months to 16 years old, who had ingested from about 36 to over 340 mg. salicylic acid (mainly as aspirin) per kg. of body weight. The apparent volume of distribution of salicylate ranged from 162 to 345 ml./kg. and increased with increasing dose. This means that plasma salicylate concentrations in children who have ingested large doses of the drug are proportionately not as high as those in children who ingested lower doses of salicylate. These observations help to rationalize the use of the Done nomogram (which involves estimation of initial salicylate concentrations by back extrapolation) to assess the severity of salicylate intoxication on the basis of plasma salicylate concentrations. (Supported in part by grants GM19568 and RR-628 from the National Institutes of Health)
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Levy, G., Yaffe, S. RELATIONSHIP BETWEEN DOSE AND APPARENT VOLUME OF DISTRIBUTION OF SALICYIATE IN CHILDREN. Pediatr Res 8, 365 (1974). https://doi.org/10.1203/00006450-197404000-00149
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DOI: https://doi.org/10.1203/00006450-197404000-00149
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