Abstract
ABSTRACT. Quantitative assays for C3 and C4 activation were carried out simultaneously on blood from children with varied types of juvenile arthritis. Factor VIII-related antigen was also measured as an indicator of vascular damage. In active systemic juvenile arthritis, the C4d/C4 ratio was frequently elevated and was usually associated with elevated C3d/C3 ratios and elevated concentrations of factor VIII-related antigen. Children with chronic polyarticular arthritis, no matter which forms of onset they had had, also had increased levels of the C4d/C4 ratio, C3d/C3 ratio, and factor VIII-related antigen, but these were less consistent and were not associated with each other. In contrast, in pauciarticular arthritis there was a uniquely isolated increase in the C3d/C3 ratio. This work implies that there are different mechanisms responsible for complement activation in the different types and at different stages of juvenile arthritis.
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Miller, J., Olds, L., Silverman, E. et al. Different Patterns of C3 and C4 Activation in the Varied Types of Juvenile Arthritis. Pediatr Res 20, 1332–1337 (1986). https://doi.org/10.1203/00006450-198612000-00030
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DOI: https://doi.org/10.1203/00006450-198612000-00030