Abstract
ABSTRACT: It has been demonstrated recently that a specific region of neural crest contributes cells to the septa of the outflow tract of the heart. Removal of this region of cardiac neural crest prior to migration from the neural fold results in persistent truncus arteriosus in chick embryos. Removal of other regions of cranial neural crest results in double outlet right ventricle. Since double outlet right ventricle is produced by manipulation of noncardiac neural crest, this malformation is thought to be an indirect rather than direct effect of neural crest ablation. The cranial neural crest forms the walls of all of the aortic arch arteries and it is proposed herein that flow abnormalities are produced in the pharyngeal region by injury to the neural crest. These abnormal hemodynamic characteristics influence heart development. Cardiac neural crest seeds the heart with parasympathetic postganglionic neurons as well as ectomesenchyme. Removal of the cardiac neural crest results in cardiac malformations because of the decreased ectomesenchymal cells. However, the neural population undergoes regeneration and so the innervation of malformed hearts is morphologically normal. The mechanism for this regeneration is not understood.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kirby, M. Cardiac Morphogenesis—Recent Research Advances. Pediatr Res 21, 219–224 (1987). https://doi.org/10.1203/00006450-198703000-00001
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1203/00006450-198703000-00001
This article is cited by
-
Expanding the phenome and variome of the ROBO-SLIT pathway in congenital heart defects: toward improving the genetic testing yield of CHD
Journal of Translational Medicine (2023)
-
A quantitative assessment of aorta root rotation in patients with tetralogy of Fallot evaluated by MSCT
Scientific Reports (2021)
-
Tissue–Tissue Interactions During Morphogenesis of the Outflow Tract
Pediatric Cardiology (2010)
-
Effects of trichloroethylene and its metabolite trichloroacetic acid on the expression of vimentin in the rat H9c2 cell line
Cell Biology and Toxicology (2005)
-
Abnormalities in lymphocyte populations in infants with neural crest cardiovascular defects
Pediatric Cardiology (1996)