Abstract
ABSTRACT.: We characterized the lipid-lipoprotein abnormalities encountered in a series of 45 nonnephrotic uremic children with various degrees of chronic renal insufficiency. A mild hypertriglyceridemia associated with decreased serum high-density lipoprotein cholesterol levels was confirmed. The correlation between high-density lipoprotein cholesterol and creatinine clearance showed a power behavior with a marked decrease in high-density lipoprotein cholesterol below a creatinine clearance value of 40 ml/min/1.73 m2 A number of uremic children accumulate an abnormal population of very low-density lipoprotein particles in their plasma. On agarose gel electrophoresis these particles migrate as a slow moving pre-/β band and are clearly distinguished from the regular fast moving pre-/β very low-density lipoprotein band. This electrophoretic phenomenon has been called double pre-/β lipoproteinemia. The prevalence of double pre-£ lipoproteinemia increased significantly with the degree of impairment of renal function, reaching highest figures in patients on hemodialysis. Accordingly, the very low-density lipoprotein cholesterol/triglyceride ratio also was significantly increased. The double pre-/β lipoproteinemia phenomenon was not detected in any of the control, nonuremic subjects. The clinical importance of double pre-/β lipoproteinemia in uremic plasma is related to its possible atherogenic role.
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Zacchello, G., Pagnan, A., Sidran, M. et al. Further Definition of Lipid-Lipoprotein Abnormalities in Children with Various Degrees of Chronic Renal Insufficiency. Pediatr Res 21, 462–465 (1987). https://doi.org/10.1203/00006450-198705000-00008
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DOI: https://doi.org/10.1203/00006450-198705000-00008
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