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Patient Age and Preoperative Breast MRI in Women With Breast Cancer: Biopsy and Surgical Implications

  • Breast Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The influence of patient age on multidisciplinary treatment planning after preoperative breast magnetic resonance imaging (MRI) and its influence on the surgical decision-making process are unclear.

Methods

We performed a retrospective review of 710 women with breast cancer who underwent preoperative MRI at our institution between January 2003 and December 2008. Analysis by patient age included the number of additional ipsilateral MRI findings, the number of biopsies recommended/performed, the number of additional cancers found, and the percentage of patients undergoing mastectomy.

Results

Of the 710 patients, 343 (48%) had additional ipsilateral MRI findings. After stratifying by age, the incidence of additional ipsilateral findings differed between decades (P = 0.004). However, fewer biopsies were recommended in older patients (P = 0.043). The number of women pursuing preoperative needle biopsy increased with age (P = 0.0018), while the incidence of a second focus of breast cancer did not change with age (P = 0.07). The mastectomy rate decreased from 65% in women younger than 50 to 40% in women older than 70 (P < 0.001).

Conclusions

In the setting of newly diagnosed breast cancer, the value of MRI is not influenced by patient age, with at least 40% of women in all age groups having additional findings on MRI. Insisting on preoperative needle biopsy of additional findings may decrease mastectomy rates. Further study is needed to determine the reasons for the increased percentage of mastectomies in younger women.

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Conflict of interest

The authors declare no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Surgery, Mayo Clinic Florida, Jacksonville, FL, USA

    Cameron D. Adkisson MD & Sarah A. McLaughlin MD

  2. Department of Radiation Oncology, Mayo Clinic Florida, Jacksonville, FL, USA

    Laura A. Vallow MD & Kristin Kowalchik MD

  3. Department of Biostatistics, Mayo Clinic Florida, Jacksonville, FL, USA

    Rebecca McNeil PhD

  4. Department of Internal Medicine, Mayo Clinic Florida, Jacksonville, FL, USA

    Stephanie Hines MD

  5. Section of Breast Imaging, Department of Radiology, Mayo Clinic Florida, Jacksonville, FL, USA

    Elizabeth Deperi MD

  6. Division of Hematology Oncology, Department of Internal Medicine, Mayo Clinic Florida, Jacksonville, FL, USA

    Alvaro Moreno MD, Vivek Roy MD & Edith A. Perez MD

Authors
  1. Cameron D. Adkisson MD
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  2. Laura A. Vallow MD
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  3. Kristin Kowalchik MD
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  4. Rebecca McNeil PhD
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  5. Stephanie Hines MD
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  6. Elizabeth Deperi MD
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  7. Alvaro Moreno MD
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  8. Vivek Roy MD
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  9. Edith A. Perez MD
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  10. Sarah A. McLaughlin MD
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Corresponding author

Correspondence to Sarah A. McLaughlin MD.

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Adkisson, C.D., Vallow, L.A., Kowalchik, K. et al. Patient Age and Preoperative Breast MRI in Women With Breast Cancer: Biopsy and Surgical Implications. Ann Surg Oncol 18, 1678–1683 (2011). https://doi.org/10.1245/s10434-010-1491-4

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  • DOI: https://doi.org/10.1245/s10434-010-1491-4

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