Splicing-factor alterations in cancers
- Corresponding authors: olga.anczukow{at}jax.org, krainer{at}cshl.edu
Abstract
Tumor-associated alterations in RNA splicing result either from mutations in splicing-regulatory elements or changes in components of the splicing machinery. This review summarizes our current understanding of the role of splicing-factor alterations in human cancers. We describe splicing-factor alterations detected in human tumors and the resulting changes in splicing, highlighting cell-type-specific similarities and differences. We review the mechanisms of splicing-factor regulation in normal and cancer cells. Finally, we summarize recent efforts to develop novel cancer therapies, based on targeting either the oncogenic splicing events or their upstream splicing regulators.
Footnotes
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Article and publication date are at http://www.rnajournal.org/cgi/doi/10.1261/rna.057919.116.
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