Keywords
Clinical trial, Participant recruitment, Recruitment interventions, Participant selection, Recruitment strategies
This article is included in the Research on Research, Policy & Culture gateway.
Clinical trial, Participant recruitment, Recruitment interventions, Participant selection, Recruitment strategies
CINAHL, Cumulative Index to Nursing and Allie Health Literature; CONSORT, Consolidated Standards of Reporting Trials; EMBASE, Excerpta Medica database; GRADE, Grading of Recommendations Assessment, Development and Evaluation; MEDLINE, Medical Literature Analysis and Retrieval System Online; MRC, Medical Research Council; PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses; RCT, randomised controlled trial; ROBINS-I, Risk Of Bias in Non-randomised Studies – of Interventions; SWAT, study within a trial
Randomised controlled trials (RCTs) are at the core of evidence-based healthcare. They use random assignments to allocate participants to treatment groups, and therefore guard against selection bias1, whether these involve medicinal products, devices or services. Recruiting participants can be difficult, as can the process of recruiting clinicians to work on the trial with and on behalf of the trial team2.
One important source of evidence for trialists looking for rigorously evaluated evidence on how to effectively recruit participants to trials is the 2018 Cochrane systematic review of interventions to improve trial recruitment3. Despite having no date or language restrictions and including 72 recruitment comparisons, just three are supported by high-certainty evidence3.
This systematic review reported here uses a similar process to the 2018 Cochrane systematic review of interventions to improve trial recruitment3, but with one substantial difference. This review focusses only on recruitment interventions that are evaluated using non-randomised methods. Until now, systematic reviews of non-randomised studies of recruitment interventions have been scarcely undertaken due to the perception that non-randomised studies are individually, of low methodological quality. However, the systematic evaluation of a substantial amount of research activity is necessary and worthwhile; without collation, this body of evidence is currently being ignored, and may hold substantial/promising undiscovered effects. Whether evidence of benefit is found for one or more interventions, the trials community will benefit from knowing the outcome of this review. Moreover, aggregating data from non-randomised studies using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach4, may raise confidence in the overall body of evidence, and supplement the evidence-base from randomised studies.
We conducted a systematic review of non-randomised studies that evaluated the effects of strategies to improve recruitment of participants to RCTs.
The full protocol for this review has been previously published5 and registered with PROSPERO (CRD42016037718). No amendments have been made to the protocol since its publication. A brief summary of methods is given below.
Non-randomised studies of two or more interventions to improve recruitment to a randomised trial. ‘Non-randomised studies’ are defined as any quantitative assessment of a recruitment intervention that did not randomly allocate participants to intervention or comparison groups. No additional eligibility criteria (e.g. publication year, status, language or journal) were applied.
Individuals enrolled in a trial. The context of the trial is likely to be healthcare but may not be, for the reason that interventions that are effective in other fields may also be applicable to settings in the healthcare environment.
Any intervention or approach aimed at improving or supporting recruitment of participants nested within studies performed for purposed unrelated to recruitment.
Primary: Number of individuals or centres recruited into a trial.
Secondary: Cost of using the recruitment intervention per trial participant.
We searched the following electronic databases without language restriction for eligible studies: Cochrane Methodology Register (CMR), Medical Literature Analysis and Retrieval System Online (MEDLINE), MEDLINE In-Process, Excerpta Medica dataBASE (EMBASE), Cumulative Index to Nursing and Allied Health Literature (CINAHL), and PsycINFO. The full search strategy is published and freely accessible5. Reference lists of relevant systematic reviews (e.g. 3) and included studies were hand-searched.
The literature searches were carried out between 16th October and 11th November 2015. On 2nd August 2018 an updated search was made in all databases, and a further 2,521 abstracts were found. 460 abstracts from 2018 were screened in duplicate, which led to 10 full texts being checked for inclusion. The ten full texts detailed ten studies, none of which provided sufficient detail about the design or implementation of interventions to allow us to pool data. Adding these studies into the review would not strengthen or disprove the conclusions we had already drawn. For this reason, we have chosen not to carry out a full updated search, and all data presented in this paper reflect the full literature searches carried out in 2015.
Two reviewers (HRG and one other) independently screened the abstracts of all search records. Full texts of potentially eligible abstracts were then independently reviewed by HRG and one other to determine inclusion. Disagreements were resolved through discussion.
Search results were merged, duplicate records removed, and a master spreadsheet was used to track all inclusions/exclusions to allow us to create a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram (Figure 1). Data were extracted by two reviewers independently (HRG and one other) and collected on specially designed forms (Extended Data File 1 Blank data extraction form 6). Disparities were resolved through discussion.
Two members of the project team used the ROBINS-I tool7 to assess studies for aspects of methodological quality such as confounding, participant selection, intervention measurement, departures from the intended intervention, missing data, outcome measurement and selection of the reported result. As per ROBINS-I guidance, studies at critical risk of bias were excluded from any synthesis.
Studies were analysed according to the type of intervention used; interventions were grouped when their form or content was deemed sufficiently alike. We planned to further categorise studies by participant if we found the same intervention applied to more than one type of participant (e.g. patients, staff at recruiting centres).
Attempts were made to contact study authors to obtain missing data. Analyses were conducted on an intention-to-treat basis where possible; alternatively, data were analysed as reported.
The nature of the included studies meant that much of the analysis was anticipated to be narrative. Where population, intervention and outcome were sufficiently similar to allow for a meta-analysis, we planned to look for visual evidence of heterogeneity in forest plots, and statistical evidence of heterogeneity using the chi-square test for heterogeneity and the degree of heterogeneity quantified using the I2 statistic9. Where substantial heterogeneity was detected (I2 ≥ 50 %), we planned to investigate possible explanations informally and summarise data using a random-effects analysis where appropriate.
We screened a total of 9,642 abstracts identified by the database search, and 231 articles found through hand searching of review article reference lists. Of the screened abstracts, 256 were suitable to assess for inclusion at full-text stage. We were unable to obtain the full text of 33 of the 256 articles (details in Extended Data File 2 References to studies awaiting assessment6). Of the 223 full-text articles assessed, 124 were excluded; this includes seven articles which required additional data to allow for inclusion (details of excluded studies in Extended Data File 3 Characteristics of excluded studies6). A total of 99 full texts were included, which comprised 102 individual studies; 92 of these were considered to be at serious risk of bias while ten were considered to be at critical risk of bias. The latter group were excluded from the study as per ROBINS-I guidance (see risk of bias assessments for these studies in Extended Data File 4 Studies that were at a critical risk of bias and therefore excluded from this review6).
Of the 92 included studies, 90 studies assessed interventions that aimed to improve the recruitment of participants to trials (55123 individuals and 172 couples), one assessed an intervention that aimed to improve the recruitment of GP practices to trials (54 practices), and one assessed an intervention that aimed to improve recruitment of GPs (150 GPs). 23 studies reported data on cost per recruit. Study size ranged between 14 and 5887 participants.
The design of included studies varied substantially and did not always fit into conventional design categories. Most studies (82/92) were what we describe as ‘yield’ studies. These types of studies appear not to have been planned as a method aiming to rigorously evaluate a recruitment intervention or interventions; rather, authors retrospectively report what methods have been used to recruit participants into the trial. Reporting of yield studies tends to rely on self-report by participants, although where online methods were used, the calculation of participant yield was recorded by the software or website; e.g. via number of clicks recorded by Facebook.
The remaining study types included in this review included cohort (7/92) and before and after designs (3/92).
Of the 92 included studies, 72 were classified as at a ‘moderate’ or ‘serious’ risk of bias in one of more domains as well as the bias due to confounding domain. The remaining 20 studies were at ‘serious’ risk of bias in the confounding domain but were deemed to be at ‘low’ risk of bias across all other domains (participant selection, intervention classification, deviations from intervention, missing data, outcome measurement, selection of reported result).
We made the decision to focus on the 20 studies at least risk of bias in the Results and Discussion sections of this review. Primarily, this reflects our confidence in the evidence presented and follows a similar approach taken in the 2018 Cochrane recruitment review3. Data from the 72 studies that we have chosen not to focus on are presented in Extended Data File 5 Characteristics of included studies6. The 20 studies that we focus on here are organised into seven broad intervention categories (full references to these studies are presented in Extended Data File 6 References for the 20 studies included in the results section of this review6).
The seven intervention categories are:
Face to face recruitment initiatives
Postal invitations and responses
Language adaptations
Randomisation methods
Trial awareness strategies aimed at the recruitee
Trial awareness strategies aimed at the recruiter
Use of networks and databases
Due to the nature of the studies included in this synthesis, the above intervention categories frequently overlap to some extent within one study. Where lines between categories were not clear or distinct, we placed studies according to the emphasis given by the original study authors.
Table 1 shows the number of participants, GPs, and practices recruited as a result of various interventions across the seven categories for the 20 studies. This table should be viewed with caution because the general lack of denominators means that direct and meaningful comparison within and across categories is not possible, as described below.
Comparing data within categories. The details of the interventions evaluated in these studies are limited, so to bring order to the variety of interventions, we have assigned them to broad categories. Each of these categories includes a range of interventions, the majority of which we are unable to thoroughly describe. For this reason, we urge you not to compare data within categories. By this we mean looking at two studies, e.g. Andersen 2010 and Bell-Syer 2000, seeing that 87 out of 187 participants and 104 out of 187 participants were recruited using face to face recruitment initiatives respectively, and assuming that these values demonstrate the success or failure of specific face to face recruitment initiatives.
We have simply used categories to bring order to the variety of interventions included in this review; each category includes a diverse range of interventions. This diversity in interventions means that none of the data presented have been pooled, and it is important that caution is exerted when interpreting data to ensure that we do not assign influence to studies where they are not deserving of it.
Comparing data across categories. Similarly, we urge you not to compare data across categories. By this, we mean looking at a study, e.g. Andersen 2010, seeing the 87 participants were recruited using face to face recruitment initiatives, and 100 participants were recruited using postal invitations and responses, and making a judgement about the success (or failure) of either of the interventions used. It’s important to bear in mind that these data do not provide denominators; there is no way for us to know how many people were exposed to either of these interventions, or over what time period, in order to recruit 187 participants.
Ten studies (totalling 3853 participants and 150 GPs) evaluated face to face recruitment initiatives, two of which used cohort studies, and eight used yield studies (see Table 1 and Table 2).
Face to face recruitment initiatives varied across the ten studies in this category; largely they focussed on recruitment of participants who were attending appointments with their primary care physician or GP, other studies looked at recruiting participants who were in the waiting room of their care-provider before an appointment took place. In most cases, waiting room recruitment was facilitated by a research nurse. Other methods used include referral of participants from different parts of their own clinical care pathway, though most were targeted around an existing appointment made by the potential participant. These care pathways included outpatient appointments, appointments at community institutions, academic institutions, and at veterans’ health administration centres.
Despite the superficial similarity of the interventions used within this category, both the diversity of comparators, settings and populations, and the poor reporting of the specifics of the interventions, made pooling data unfeasible.
One study (2575 participants) evaluated language adaptations; Barrera 2014 compared translations of Google AdWords in Spanish or English language using a yield study (see Table 1 and Table 2). The trial was based online within the USA and aimed to recruit pregnant women to a trial of an internet intervention for postpartum depression, the embedded recruitment study did not account for variations in how common postpartum depression is in Spanish-speaking populations in comparison to English-speaking populations.
Nine studies (totalling 1614 participants) evaluated postal invitations and responses, two of which used cohort studies, and the other seven used yield studies (see Table 1 and Table 2).
Postal invitations and responses were used widely within the studies included in this review. Largely interventions within this category were based on patient lists held by caregivers; letters were sent out and then the number of responses from potential participants monitored, in most cases these studies reported the number of responses from people that ultimately went on to be recruited into the study. As mentioned in the ‘face to face recruitment initiatives’ section, many of the postal interventions used a face to face method as their comparator. Despite the superficial similarity of the interventions used within this category, both the diversity of their comparators, settings and populations, and the poor reporting of the specifics of the interventions, made pooling data unfeasible. In only one case (Funk 2010), did comparators vary from this trend. In this study, the method of response to a mailed brochure was monitored; potential participants were given the option of responding to the mailing by telephone or a website. These comparators were unusual within the literature, and draw attention to the two-dimensional nature of many of the other studies within this category; largely researchers looking at postal methods are focussing on the method used to contact potential participants, rather than the ways that these individuals may respond.
One study (553 participants) evaluated randomisation methods; Brealey 2007 compared use of telephone and postal randomisation methods using a yield study (see Table 1 and Table 2). Initially, general practices involved used a telephone service to randomise patients to the host trial. Delays in the start of recruitment at some sites led the team to modify the randomisation procedure to include postal randomisation. Following this, new sites were given the option to use either postal or telephone randomisation methods.
Four studies (totalling 407 participants) evaluated trial awareness strategies aimed at the recruitee, one of which used a before and after study, and the remaining three used yield studies (see Table 1 and Table 2).
This category is diverse; the four studies include four distinct interventions. The reporting of these interventions is ambiguous; for example, Carr 2010 describes a community outreach event, Johnson 2015 describes a non-targeted flyer, and Sawhney 2014 describes increased awareness of the trial via use of a telephone reminder prior to their clinic appointment. It is feasible that all of these interventions could come under the umbrella of ‘trial awareness strategies aimed at the recruitee’ which is what is described by Carter 2015. The text states that Carter 2015’s interventions included distribution of leaflets and posters at clinics, therapy centres and regional multiple sclerosis societies, presentations and attendance at regional multiple sclerosis events and to local physiotherapy teams, and referral from other professional such as multiple sclerosis nurses and word of mouth.
Fives studies (totalling 188 participants and 54 practices) evaluated trial awareness strategies aimed at the recruiter, one of which used a cohort study, two used before and after studies, and two used yield studies (see Table 1 and Table 2).
Again, the interventions evaluated within this category are diverse: Carr 2010 looked at a medical education event; Embi 2005 and Treweek 2010 looked at methods of clinical trial alert software set to trigger during clinic appointments; Beauharnais 2012 assessed effectiveness of an automated pre-screening algorithm to identify potential participants; and Colwell 2012 evaluated the use of viral marketing techniques in the form of postcards, invitation letters and flyers. The diversity of these interventions means that data could not be pooled.
Two studies (totalling 486 participants) evaluated the use of networks and databases, both of which used yield studies (see Table 1 and Table 2).
Park 2007 compared centralised recruitment efforts with de-centralised approaches that were tailored to the study and sites specifically. Weng 2010 evaluated effectiveness of existing lists of potentially eligible participants; comparing a clinical patient registry with a clinical data warehouse. The interventions are sufficiently different that data could not be pooled.
This review identified 92 studies, 20 of which were included in a narrative synthesis; those 20 studies evaluated the effect of seven categories of interventions to improve recruitment to randomised trials.
The interventions evaluated in these studies varied significantly; even those that had an intervention category in common were sufficiently dissimilar to prevent pooling of data, rendering sub-group analyses unfeasible. That said, what limits the utility of these studies is not necessarily the interventions evaluated; it is the abundance of small study samples sizes, inadequate reporting, and a lack of coordination when it comes to deciding what to evaluate and how.
This review does not show ground-breaking evidence that will change the global landscape of how trialists recruit participants into trials. However, the 2018 Cochrane recruitment review3 of randomised evaluations of recruitment interventions was not able to provide clear evidence of benefit for the majority of interventions either. Like this review, the randomised review also experienced challenges with small, methodologically flawed studies, a diverse range of interventions, and a lack of detailed reporting. This fact may not be comforting for trialists, but it demonstrates that the utility of non-randomised studies is not always vastly different from their randomised counterparts.
Non-randomised evaluations have acquired a bad reputation, but they do have their merits. Randomised evaluations are not always possible because of logistics, financial resources, or ethical reasons10, and non-randomised studies could allow researchers to gather useful data to complement or replace data generated by randomised trials11.
It is clear that non-randomised evaluations of recruitment interventions will continue. In their current form, however, we found their usefulness to others to be extremely limited. What we need to focus on now is improving the way that these non-randomised evaluations are planned, conducted and reported.
The non-randomised studies that are included in this review largely take the form of what we refer to as ‘yield’ studies. As described earlier, these types of studies appear not to have been planned as a means to rigorously evaluate a recruitment method; instead, they represent the work of authors retrospectively reporting what they have done, and subsequently what they have seen.
This practice limits utility of these studies in two ways:
1. The studies are not designed in such a way as to lend themselves to straightforward analysis, which means that interventions and their comparator are not always introduced at the same time or used for the same length of time. A lack of planning also results in the collection of data that are incomplete and lack context; this is a problem that features in most studies included in this review. Data are presented in terms of numerators; they provide numbers of participants/GPs/practices recruited into a trial, but do not provide a denominator, meaning that comparing interventions to assess effectiveness is impossible.
2. As is clear from the larger intervention categories such as face to face recruitment initiatives, and postal invitations and responses, the trials community is currently lacking a consistent approach to the non-randomised evaluations that they are publishing.
Rather than reporting what has been done retrospectively, we would encourage trialists to prospectively plan to embed recruitment evaluations, specifically using a study within a trial (SWAT) protocol12 that already exists on the SWAT repository13, into their trials from the very beginning of the process of planning the host trial. The Medical Research Council Systematic Techniques for Assisting Recruitment to Trials (START) project is a remarkable example of the effectiveness of a well-planned, organised and cohesive approach to SWATs14; the project ran between 2009 and 2015 and answered its research question regarding optimised participant information sheets within the space of six years. The follow-on PROMETHEUS project is co-ordinating over 30 recruitment and retention SWATs and will substantially increase global evidence for trial recruitment and retention in the space of around four years. Without coordination of high-quality evaluations, it is entirely possible for a decade to pass without materially increasing the evidence base available to trialists, as a comparison of the 200715 and 20183 Cochrane recruitment reviews demonstrates.
The process of conducting non-randomised evaluations of recruitment lacks structure; limited planning means that many of the studies included in this review were penalised as a result of poor conduct.
74% of included studies were judged to be at moderate risk of bias in the ‘bias in classification of interventions’ domain of the ROBINS-I tool. These studies were most often penalised as a result of blurred lines between interventions and their comparators. For example, Adams 1997 (Extended Data File 5 Characteristics of included studies6) compares the effectiveness of professional referrals, cold calling by the research team, presentations at senior centres, media outreach, mailings sent to personal care home managers, and flyers; a total of six interventions. Participants could conceivably have been drawn to take part in the trial as a result of more than one of these six interventions; someone could have seen the media outreach campaign, received a flyer, and attended a presentation at a senior centre. This, combined with self-report of one method by participants, makes meaningful interpretation of the results extremely difficult.
Currently, trialists are focussing on the mode of delivery of the interventions that they are working to evaluate; they omit key details regarding the content of the intervention, as well as the specific timescales that interventions were in place for. We highly encourage the use of the Guidelines for Reporting Non-Randomised Studies16, and the Template for Intervention Description and Replication (TIDieR) checklist and guide17 when reporting these types of studies.
Missing data was another aspect of reporting where detail was lacking. Of the 92 included studies, 13% were deemed to be at serious risk of bias due to missing data; a glaring example of research waste. Pieces of data that were missing were not entire data categories or a reflection of participants being lost to follow-up; in some cases, the data simply did not add up. One example is Blackwell 2011; this paper reported recruitment of 301 participants, but when we manually calculated how many participants had been recruited across each of the seven methods used in the study, and also included the participants that were reported as ‘don’t know/refused/other’, the total was 303 participants. The size of the discrepancy may appear trivial, but it undermines confidence in the data presented and the study generally. This was not a unique occurrence; missing data were also found in Brownstone 201218, Freret 200319, Kernan 200920, Lewis 199821, Martin 201122, McDermott 200923, Piantadosi 201524, Silagy 199125, Tenorio 201126, Unlü Ince 201427, and Zhou 201328. If non-randomised evaluations of recruitment interventions are to have any value, how they are reported needs to improve.
Some interventions to increase recruitment described in this review do show promise but methodological and reporting problems mean that our confidence in these results is not substantial enough to recommend changes to current recruitment practice. Currently the literature is oversaturated with a diversity of interventions tested in non-randomised evaluations that fail to drill down deep into the effects of each specific recruitment strategy. Their usefulness to other trialists is therefore extremely limited.
What is needed now is a move away from retrospective descriptions of what happened, to carefully planned prospective evaluations of well-described recruitment interventions and their comparators. Without this change, authors of non-randomised evaluations of recruitment interventions are simply contributing to research waste.
All data underlying the results are available as part of the article and no additional source data are required.
Open Science Framework: A systematic review of non-randomised evaluations of strategies to improve recruitment to randomised controlled trials. https://doi.org/10.17605/OSF.IO/98BQ46
This project contains the following extended data:
- Extended Data File 1 Blank data extraction form.docx
- Extended Data File 2 References to studies awaiting assessment.docx
- Extended Data File 3 Characteristics of excluded studies.docx
- Extended Data File 4 Studies that were at a critical risk of bias and therefore excluded from this review.docx
- Extended Data File 5 Characteristics of included studies.docx
- Extended Data File 6 References for the 20 studies included in the results section of this review.docx
Open Science Framework: A systematic review of non-randomised evaluations of strategies to improve recruitment to randomised controlled trials. https://doi.org/10.17605/OSF.IO/98BQ46
Data are available under the terms of the Creative Commons Attribution 4.0 International license (CC-BY 4.0).
We would like to thank Beverley Smith for her help with obtaining full-text articles, and Polly Black, Gordon Fernie, Kirsty Loudon, Sarah Stirrup, and Daniel Williams for their help with data extraction. Daniel Williams was supported by a summer internship with Medical Research Scotland.
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Are the rationale for, and objectives of, the Systematic Review clearly stated?
Yes
Are sufficient details of the methods and analysis provided to allow replication by others?
Yes
Is the statistical analysis and its interpretation appropriate?
I cannot comment. A qualified statistician is required.
Are the conclusions drawn adequately supported by the results presented in the review?
Yes
Competing Interests: No competing interests were disclosed.
Reviewer Expertise: Qualitative Researcher: Randomised Controlled Trials, Equipoise, Recruitment and Retention.
Are the rationale for, and objectives of, the Systematic Review clearly stated?
Yes
Are sufficient details of the methods and analysis provided to allow replication by others?
Partly
Is the statistical analysis and its interpretation appropriate?
Not applicable
Are the conclusions drawn adequately supported by the results presented in the review?
No
Competing Interests: No competing interests were disclosed.
Reviewer Expertise: Evidence synthesis
Are the rationale for, and objectives of, the Systematic Review clearly stated?
Yes
Are sufficient details of the methods and analysis provided to allow replication by others?
Partly
Is the statistical analysis and its interpretation appropriate?
Not applicable
Are the conclusions drawn adequately supported by the results presented in the review?
Yes
Competing Interests: No competing interests were disclosed.
Reviewer Expertise: Severe mental illness, smoking cessation, RCTs
Are the rationale for, and objectives of, the Systematic Review clearly stated?
Yes
Are sufficient details of the methods and analysis provided to allow replication by others?
Yes
Is the statistical analysis and its interpretation appropriate?
Not applicable
Are the conclusions drawn adequately supported by the results presented in the review?
Partly
References
1. Schünemann HJ, Cuello C, Akl EA, Mustafa RA, et al.: GRADE guidelines: 18. How ROBINS-I and other tools to assess risk of bias in nonrandomized studies should be used to rate the certainty of a body of evidence.J Clin Epidemiol. 111: 105-114 PubMed Abstract | Publisher Full TextCompeting Interests: No competing interests were disclosed.
Reviewer Expertise: Evidence synthesis, RCTs, process evaluation
Are the rationale for, and objectives of, the Systematic Review clearly stated?
Yes
Are sufficient details of the methods and analysis provided to allow replication by others?
Yes
Is the statistical analysis and its interpretation appropriate?
Yes
Are the conclusions drawn adequately supported by the results presented in the review?
Partly
Competing Interests: No competing interests were disclosed.
Reviewer Expertise: Trial operations methodology research
Alongside their report, reviewers assign a status to the article:
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Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality. Consider the following examples, but note that this is not an exhaustive list:
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