Keywords
Ophthalmology, glaucoma, glaucoma surgery, glaucoma tube shunt, glaucoma patch graft, collagen matrix
This article is included in the Eye Health gateway.
Ophthalmology, glaucoma, glaucoma surgery, glaucoma tube shunt, glaucoma patch graft, collagen matrix
The use of glaucoma drainage implants to treat difficult glaucoma cases has increased in the past two decades1. These devices drain aqueous through a silicone tube to a reservoir plate covered by Tenon’s capsule and conjunctiva. The tube is then covered by one of several materials to prevent exposure to the overlying conjunctiva. Although most complications are transient and self-limited, glaucoma drainage procedures carry the risk of persistent corneal edema, tube erosion, endophthalmitis/blebitis, and tube migration, among other complications2. Tube shunts in particular carry the risk of patch graft thinning and exposure of the subconjunctival portion of the shunt tube, which is a risk factor for infectious endophthalmitis3,4. Prompt identification and revision of exposed patch grafts with collagenous human autograft or allograft material is therefore recommended5.
Several patch graft materials have been used. These include pericardium, fascia lata, cornea, sclera, and amniotic membrane6,7. Ologen (Aeon Astron Europe BV, Leiden, the Netherlands) is a porcine-derived biodegradable collagen matrix implant which has been studied and used as an adjunct to trabeculectomy8,9. A recent case report showed successful use of Ologen as a patch before closing the conjunctiva in a case of tube erosion10. To our knowledge, Ologen has not been used as a primary patch graft in glaucoma tube shunt procedures. Collagen matrix may be advantageous because it does not need to be harvested from human donors and is less expensive than other patch graft materials. This is particularly important considering that Medicare (the federal health insurance program for people who are 65 or older, medicare.gov) now no longer reimburses for any patch graft material when combined with a tube shunt procedure (former CPT code 67255). Additionally, Ologen appears clear under the conjunctiva and provides improved cosmesis compared to other patch grafts (Figure 1, printed with permission courtesy of Steven R. Sarkisian, jr.). The purpose of this study was to determine the safety and efficacy of collagen matrix as a patch graft in glaucoma tube shunt surgery.
This study was approved and monitored by the Institutional Review Board at the University of Oklahoma Health Science Center (IRB# 3425; reference #652312). Permission to publish clinical details and images was obtained for each subject. Potential subjects were identified by reviewing case logs of a single attending surgeon (S.R.S.). Charts of consecutive patients undergoing glaucoma tube shunt surgery with placement of collagen matrix patch graft between July 2009 and December 2010 were reviewed. Charts were excluded if the patient had less than 12 months of follow-up data. Forty-three eyes of 40 patients were identified. Demographic and clinical information of the patients is listed in Table 1. The primary outcome measure of this study was post-operative tube exposure requiring revision.
The glaucoma drainage implant of choice was placed in the usual fashion11. Once the tube was secured to the sclera, the collagen patch graft was used to cover the tube (Figure 2). The Ologen to cover a tube comes as a 10Ă—10Ă—2 mm sheet. Presoaking the collagen is not necessary and is, in fact discouraged because once wet, the collagen becomes difficult to cut and can tear easily. While dry, the collagen sheet was cut to size to cover the tube per the surgeon's preference. Although some surgeons may desire to suture the collagen in place, we find this unnecessary as the collagen quickly picks up moisture from the scleral bed, does not slide out of place easily and never moves post-operatively once the conjunctiva is closed. However, great care is taken to ensure that the collagen is fully covered and the conjunctiva covering it is not under tension. Every effort must be made to be certain there is no chance that any part of the collagen is exposed and the conjunctiva is well secured. Once the conjunctiva was closed, a small amount of saline was placed in the anterior chamber and a fluorescein strip was used to verify the absence of leakage.
A brief summary of results is displayed in table 2. Forty-one of 43 (95.4%) eyes with Ologen patch graft required no intervention for patch graft melting with tube erosion. The average time of follow-up was 32 months (range 12–45 months). Two cases had tube erosion requiring revision. These occurred at 4 months and 26 months post-operatively. The first patient was an 86-year-old Caucasian woman with open angle glaucoma and a history of iritis. She had partial exposure of the patch graft after 1 week and full exposure at 4 months. She underwent successful tube revision with conjunctiva for a total follow up of 32 months. The second erosion occurred in a 74-year-old Caucasian woman with open angle glaucoma and long-standing diabetes mellitus. The erosion occurred at 26 months and was successfully repaired with donor sclera for a total follow up of 32 months. Neither patient developed signs of endophthalmitis during their clinical course. Both of these patients had Ahmed valves placed in the superotemporal quadrant. One patient in this study, a 63-year-old man with open angle glaucoma, developed partial tube exposure on post-operative day 10 but did not require revision. He underwent placement of Baerveldt shunt in the inferonasal quadrant.
Number of eyes | 43 |
---|---|
Tube erosions (%) | 2 (4.7%) |
Average time to erosion | 15 months (2 months, 36 months) |
Successful revision | 2/2 (100%) |
Average time of follow up | 32 months (range 12–45 months) |
To our knowledge, no study has investigated the use of collagen matrix material as a primary patch graft in glaucoma tube shunt surgery. Previous studies have reported rates of patch graft erosion. Gedde et al. reported tube erosion in five of 107 eyes (4.6%) in the tube versus trabeculectomy study at 5 years of follow-up11. In a study of 702 patients, Levinson et al. reported an exposure rate of 5.8% at a mean follow up of 36 months12. Additionally, Muir et al. reported an exposure rate of 6.2% in 1073 patients followed for an average of 41 months13. The erosion rate in our study, 4.7%, is comparable to these previous studies.
Several factors may predispose patients to patch graft erosion. In a cohort study of 121 eyes, Koval et al. identified Hispanic ethnicity, neovascular glaucoma, previous trabeculectomy, and combined surgery as potential risk factors for tube shunt exposure14. In the aforementioned study by Muir et al., female gender and white race were associated with an increased risk of graft exposure. Uveitis, diabetes, and type of tube shunt were not associated with increased risk13. Mechanical and immunologic factors may also contribute to graft erosion15. Both of the patients with graft erosion in our study had histories suggestive of poor wound healing and/or ocular inflammation. One had long-standing diabetes mellitus without a diagnosis of neovascular glaucoma. The second patient with erosion in our study had a history of iritis.
Ologen encapsulates when not exposed to aqueous and does not biodegrade. It is possible that the patch graft erosions in our study occurred because the Ologen was exposed and not well-covered initially, leading to patch melting. Care must be taken to not use Ologen if the conjunctiva is under tension when it is closed.
There are several limitations to this study. First, given its relatively small sample size and limited duration, further studies are necessary to determine the safety and efficacy of Ologen collagen matrix patch grafts compared to other commonly used materials. There are inherent limitations in a retrospective chart review, including lack of randomization of patients, lack of comparative control group and incomplete follow-up by patients not reviewed for this study. A prospective, large, controlled study is needed to compare erosion rates of Ologen to other graft materials. It is possible that collagen matrix patch grafts may be used successfully in glaucoma tube shunt surgery. They may be advantageous because they do not need to be harvested from human donors, are less expensive, and provide improved cosmesis compared to other commonly used materials. Further study is required to evaluate the long-term use of Ologen as a patch graft.
F1000Research: Dataset 1. The use of collagen matrix (Ologen) as a patch graft in glaucoma tube shunt surgery, a retrospective chart review data spreadsheet. 10.5256/f1000research.9232.d13089416
This study was approved and monitored by the Institutional Review Board at the University of Oklahoma Health Science Center (IRB# 3425; reference #652312). Permission to publish clinical details and images was obtained for each subject.
SRS conceived the study and performed the procedures reviewed in this study. JS carried out the research, analyzed the results, and prepared the first draft of the manuscript. JDS and SRS were involved in the revision of the draft and manuscript and have agreed to the final content.
Dr. Sarkisian is a consultant for Alcon, Aeon Astron, Beaver Vistec, InnFocus, Sight Sciences, New World Medical, and Ellex He is currently receiving research grants from Alcon, Aeon Astron, Aerie, Transcend, Glaukos, and is a lecturer for Alcon.
This paper was funded in part by Research to Prevent Blindness.
The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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References
1. Albis-Donado O, Gil-Carrasco F, Romero-Quijada R, Thomas R: Evaluation of Ahmed glaucoma valve implantation through a needle-generated scleral tunnel in Mexican children with glaucoma.Indian J Ophthalmol. 58 (5): 365-73 PubMed Abstract | Publisher Full TextCompeting Interests: No competing interests were disclosed.
Competing Interests: No competing interests were disclosed.
References
1. El-Saied HM, Abdelhakim MA: Trabeculectomy with ologen in secondary glaucomas following failed trabeculectomy with MMC: comparative study.Eye (Lond). 2016. PubMed Abstract | Publisher Full TextCompeting Interests: No competing interests were disclosed.
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