Abstract
Adiponectin is a recently discovered protein that seems to be exclusively secreted by adipocytes and is the most abundant adipose tissue–derived protein. While some recent studies have demonstrated an association between adiponectin levels and hypertension, these studies were cross-sectional in design, and the results have been inconsistent. Therefore we performed a prospective study to elucidate the role of adiponectin in the development of hypertension. The results of this study showed that serum adiponectin levels were significantly lower in hypertensive subjects than in normotensive subjects. Moreover, in logistic regression analysis, the subjects in the lowest quartile had a 3.72-fold higher risk than those in the highest quartile. Even after adjusting for potential confounding factors, this association was found to be significant. Low serum adiponectin levels were found to be independently associated with a higher risk for the development of hypertension. Our results therefore suggest that hypoadiponectinemia is a novel predictor of hypertension.
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Trujillo ME, Scherer PE : Adiponectin—journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern Med 2005; 257: 167–175.
Arita Y, Kihara S, Ouchi N, et al: Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999; 257: 79–83.
Tajtakova M, Petrasova D, Petrovicova J, et al: Adiponectin as a biomarker of clinical manifestation of metabolic syndrome. Endocr Regul 2006; 40: 15–19.
Hara K, Horikoshi M, Yamauchi T, et al: Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome. Diabetes Care 2006; 29: 1357–1362.
Dzielinska Z, Januszewicz A, Wiecek A, et al: Decreased plasma concentration of a novel anti-inflammatory protein—adiponectin—in hypertensive men with coronary artery disease. Thromb Res 2003; 110: 365–369.
Kumada M, Kihara S, Sumitsuji S, et al: Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 2003; 23: 85–89.
Cesari M, Pessina AC, Zanchetta M, et al: Low plasma adiponectin is associated with coronary artery disease but not with hypertension in high-risk nondiabetic patients. J Intern Med 2006; 260: 474–483.
Im JA, Kim SH, Lee JW, et al: Association between hypoadiponectinemia and cardiovascular risk factors in nonobese healthy adults. Metabolism 2006; 55: 1546–1550.
Patel JV, Lim HS, Hughes EA, et al: Adiponectin and hypertension: a putative link between adipocyte function and atherosclerotic risk? J Hum Hypertens 2006; 21: 1–4.
Dogru T, Sonmez A, Tasci I, et al: Plasma adiponectin and insulin resistance in new onset hypertension. Endocrine 2006; 29: 405–408.
Della Mea P, Lupia M, Bandolin V, et al: Adiponectin, insulin resistance, and left ventricular structure in dipper and nondipper essential hypertensive patients. Am J Hypertens 2005; 18: 30–35.
Iwashima Y, Katsuya T, Ishikawa K, et al: Association of hypoadiponectinemia with smoking habit in men. Hypertension 2005; 45: 1094–1100.
Hong SJ, Park CG, Seo HS, et al: Associations among plasma adiponectin, hypertension, left ventricular diastolic function and left ventricular mass index. Blood Press 2004; 13: 236–242.
Lee HS, Lee M, Joung H : Adiponectin represents an independent risk factor for hypertension in middle aged Korean women. Asia Pac J Clin Nutr 2007; 16: 10–15.
Chow WS, Cheung BM, Tso AW, et al: Hypoadiponectinemia as a predictor for the development of hypertension: a 5-year prospective study. Hypertension 2007; 49: 1455–1461.
Murakami H, Ura N, Furuhashi M, et al: Role of adiponectin in insulin-resistant hypertension and atherosclerosis. Hypertens Res 2003; 26: 705–710.
Scherer PE, Williams S, Fogliano M, et al: A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 1995; 270: 26746–26749.
Stefan N, Stumvoll M : Adiponectin—its role in metabolism and beyond. Horm Metab Res 2002; 34: 469–474.
Kazumi T, Kawaguchi A, Sakai K, et al: Young men with high-normal blood pressure have lower serum adiponectin, smaller LDL size, and higher elevated heart rate than those with optimal blood pressure. Diabetes Care 2002; 25: 971–976.
Furuhashi M, Ura N, Higashiura K, et al: Low adiponectin level in young normotensive men with a family history of essential hypertension. Hypertens Res 2005; 28: 141–146.
Jones BH, Standridge MK, Taylor JW, et al: Angiotensinogen gene expression in adipose tissue: analysis of obese models and hormonal and nutritional control. Am J Physiol 1997; 273: R236–R242.
Furuhashi M, Ura N, Higashiura K, et al: Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertension. Hypertension 2003; 42: 76–81.
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Imatoh, T., Miyazaki, M., Momose, Y. et al. Adiponectin Levels Associated with the Development of Hypertension: A Prospective Study. Hypertens Res 31, 229–233 (2008). https://doi.org/10.1291/hypres.31.229
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DOI: https://doi.org/10.1291/hypres.31.229
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