Abstract
Recombinant toxins are cytotoxic proteins that are encoded by DNA sequences that can be expressed in prokaryotic or eukaryotic cells. The proteins contain both a ligand, for binding to cells, and a toxin, for killing the cells. In recombinant toxins the connection between the toxin and ligand is encoded by the DNA and not produced by chemical conjugation. Since recombinant toxins must bind specifically to cell surface molecules to kill cells, the number of possible recombinant toxin molecules that can bind to a cell is in the hundreds or thousands; hence, the toxins must be very potent.
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Kreitman, R.J., Pastan, I. (2000). 12 Making Fusion Toxins to Target Leukemia and Lymphoma. In: Francis, G.E., Delgado, C. (eds) Drug Targeting. Methods in Molecular Medicineā¢, vol 25. Humana Press. https://doi.org/10.1385/1-59259-075-6:215
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DOI: https://doi.org/10.1385/1-59259-075-6:215
Publisher Name: Humana Press
Print ISBN: 978-0-89603-531-7
Online ISBN: 978-1-59259-075-9
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