Abstract
The purpose of this study is to investigate the relationship between meniscal degeneration and element contents. The contents of elements (calcium, phosphorus, sulfur, and magnesium) in the menisci from 17 patients with osteoarthritis (OA) of the knee, 6 with rheumatoid arthritis (RA), and 2 who underwent the surgical operation for malignant tumors (control) were analyzed by inductively coupled plasma-atomic emission spectrometry, and the menisci were divided into four stages (Stage 0–3) of histological degeneration.
The calcium contents of the menisci were 0.26±0.16 in Stage 0, 0.50±0.37 in Stage 1, and 0.69±0.66 in Stage 2, respectively (the values represent mg elements/g dry tissue). They increased with the progression of the stage. This tendency was found in the menisci with OA, but was not clear in those with RA. The calcium content in the control group was 0.17±0.09 mg/g. There was no significant relationship between the stage of degeneration and the contents of phosphorus, sulfur, or magnesium. The calcium content of the meniscus might indicate the degree of meniscal degeneration.
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J. Raunest, H. Hötzinger, and K. F. Bürrig, Magnetic resonance imaging (MRI) and arthroscopy in the detection of meniscal degeneration: correlation of arthroscopy and MRI with histology findings, Arthroscopy 10, 634–640 (1994).
W. M. Copenhaver, D. E. Kelly, and R. L. Wood, Bailey’s Textbook of Histology, 17th ed., Williams & Wilkins, Baltimore, MD, pp. 170–178 (1978).
D. W. Stoller, C. Martin, J. V. Crues, L. Kaplan, and J. H. Mink, Meniscal tears: pathologic correlation with MR imaging, Radiology 163, 731–735 (1987).
J. Herwig, E. Egner, and E. Buddecke, Chemical changes of human knee joint menisci in various stages of degeneration, Ann. Rheum. Dis. 43, 635–640 (1984).
S. Tohno, Y. Tohno, T. Minami, M. Ichii, Y. Okazaki, F. Nishiwaki, et al., Difference of mineral contents in human intervertebral disks and its age-related change, Biol. Trace Element Res. 52, 117–124 (1996).
Y. Sumen, Y. Murakami, N. Adachi, E. Fujimoto, Y. Ikuta, and M. Ochi, Usefulness of MRI for arthroscopic treatment of meniscal tears, Kansetsukyou 22, 71–74 (1997) (in Japanese).
Y. Tachibana, M. Higano, Y. Yamazaki, T. Takimoto, and T. Fujimori, MRI of the meniscus: correlation of MRI with histologic and biochemical findings, J. Jpn. Orthop. Assoc. 72, S1495 (1998) (in Japanese).
Y. Moriwake, Y. Tohno, S. Tohno, T. Minami, M. Utsumi, F. Nishiwaki, et al., Agerelated changes of element contents in the human meniscus, Biol. Trace Element Res. 64, 229–235 (1998).
O. Ferrer-Roca and C. Vilalta, Lesions of the meniscus. Part I: macroscopic and histologic findings, Clin. Orthop. 146, 289–300 (1980).
I. Masuda, K. Ishikawa, and G. Usuku, A histologic and immunohistochemical study of calcium pyrophosphate dihydrate crystal deposition disease, Clin. Orthop. 263, 272–287 (1991).
T. Ohhira and K. Ishikawa, Histochemical localization of calcium with potassium pyroantimonate in the articular tissues in calcium pyrophosphate dihydrate crystal deposition disease, Clin. Orthop. 264, 286–294 (1991).
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Habata, T., Ohgushi, H., Takakura, Y. et al. Relationship between meniscal degeneration and element contents. Biol Trace Elem Res 79, 247–256 (2001). https://doi.org/10.1385/BTER:79:3:247
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DOI: https://doi.org/10.1385/BTER:79:3:247