Open Access, Peer-reviewed
pISSN 2384-1079
eISSN 2384-1087
    Pediatr Infect Vaccine. 2017 Apr;24(1):23-30. Korean.
    Published online Apr 18, 2017.
    https://doi.org/10.14776/piv.2017.24.1.23
    Copyright © 2017 The Korean Society of Pediatric Infectious Diseases
    Original Article

    Clinical Comparison of Influenza A and B Virus Infection in Hospitalized Children

    Seungwon Jung,1 Joon Hee Lee,1 Jin Han Kang,1 Hak Sung Lee,2 Jae Won Choi,2 Sang Hyuk Ma,2 and Jaywon Lee3
      • 1Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, the Republic of Korea.
      • 2Department of Pediatrics, Changwon Fatima Hospital, Changwon, the Republic of Korea.
      • 3Korea Advanced Institute of Science and Technology, Seoul, the Republic of Korea.
    • Corresponding author (Email: pedma@naver.com )
    Received September 02, 2016; Revised October 21, 2016; Accepted October 25, 2016.

    Abstract

    Purpose

    The objective of this study was to compare the clinical characteristics of influenza A and B infections and analyze the effect of oseltamivir in hospitalized children.

    Methods

    We investigated children under the age of 15, who were diagnosed with influenza A/H1N1, A/H3N2, or B from January to April 2014. The subjects were admitted to the Changwon Fatima Hospital and diagnosed using a rapid antigen test from nasopharyngeal swabs. The medical records of the patients were retrospectively reviewed.

    Results

    A total of 302 pediatric patients with influenza were enrolled. Influenza B infection was the most common type (n=187, 61.9%), followed by A/H3N2 (n=100, 33.1%) and A/H1N1 (n=15, 5.0%). Compared to patients diagnosed with influenza A, patients diagnosed with influenza B were older (P=0.005), and the duration of fever was significantly longer (P=0.001). A total of 161 patients (53.3%) had been vaccinated against influenza during the season, before admission. Among the patients infected with A/H3N2 and B, the duration of fever was shorter in oseltamivir recipients compared to oseltamivir non-recipients (P=0.026 and P=0.004, respectively).

    Conclusions

    There were significant differences between influenza A and B groups in terms of age, demographics, and clinical course. Although the effectiveness of oseltamivir on influenza differs according to the type of influenza, our data provides evidence that oseltamivir is beneficial for both A and B infections.

    Keywords
    Influenza, human; Oseltamivir

    Figures

    Fig. 1
    The number of children according to the age group.

    Fig. 2
    The number of children with or without familial contacts in (A) children under 24 months, and in (B) 24 months to 6 years old according to the type of influenza.

    Tables

    Table 1
    Clinical and Laboratory Characteristics according to Type of Influenza

    Table 2
    Presentation of Subjective Symptoms according to Type of Influenza in Children Aged ≥24 Months

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    MeSH Terms
    Child
    Child, Hospitalized*
    Demography
    Fever
    Gyeongsangnam-do
    Herpesvirus 1, Cercopithecine*
    Humans
    Influenza, Human*
    Medical Records
    Oseltamivir
    Retrospective Studies
    Seasons
    Metrics
    Share
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