Abstract
Aims and methods: To determine obstetrical and neonatal outcomes in referrals of apparently isolated mild ventriculomegaly following routine ultrasound scan, over the period 2001–2003. Specialist ultrasound and other investigations were performed. Neonatal examination and postnatal ultrasound findings were collected and local neurodevelopmental follow-up was obtained.
Results: 30 cases of suspected isolated mild ventriculomegaly (posterior horn of lateral ventricle 10–15 mm at diagnosis) were identified. There were two abnormal karyotypes, no abnormal TORCH screens, and only one false-positive alloimmune thrombocytopenia screen. In 21 cases, isolated ventriculomegaly was confirmed following specialist investigation. In 11 of 21 cases, ventriculomegaly resolved during antenatal follow-up, and in one case it progressed. Six of 21 had ventriculomegaly confirmed on postnatal ultrasound and lissencephaly was diagnosed in one following postnatal MRI. Of the 11 infants with antenatal resolution of ventriculomegaly, 2 have delayed development. The infant with progressive ventriculomegaly has severe developmental problems.
References
1 Achiron R, M Schimmel, A Achiron, S Mashiach: Fetal mild idiopathic lateral ventriculomegaly: is there a correlation with fetal trisomy?Ultrasound Obstet Gynecol3 (1993) 89Search in Google Scholar
2 Amiel-Tison C: A method for neurologic evaluation within the first year of life. Curr Probl Pediatr7 (1976) 110.1016/S0045-9380(76)80008-4Search in Google Scholar
3 Beke A, L Csabay, J Rigo Jr, A Harmath, Z Papp: Follow-up studies of newborn babies with congenital ventriculomegaly. J Perinat Med27 (1999) 495Search in Google Scholar
4 Bloom SL, DD Bloom, C DellaNebbia, et al.: The developmental outcome of children with antenatal mild isolated ventriculomegaly. Obstet Gynecol90 (1997) 93Search in Google Scholar
5 Bork MD, JS Smeltzer, JF Egan, JF Rodis, FJ DiMario Jr, WA Campbell: Prenatal diagnosis of intracranial lipoma associated with agenesis of the corpus callosum. Obstet Gynecol87 (1996) 845Search in Google Scholar
6 Cardoza JD, RB Goldstein, RA Filly: Exclusion of fetal ventriculomegaly with a single measurement: the width of the lateral ventricular atrium. Radiology169 (1988) 711Search in Google Scholar
7 Chervenak FA, C Duncan, LR Ment, et al.: Outcome of fetal ventriculomegaly. Lancet2 (1984) 179Search in Google Scholar
8 Dale ST, LT Coleman: Neonatal alloimmune thrombocytopenia: antenatal and postnatal imaging findings in the pediatric brain. Am J Neuroradiol23 (2002) 1457Search in Google Scholar
9 Girard N, A Ozanne, K Chaumoitre, et al.: IRM et ventriculomegalie in utero. (Full text in English on www.e2med.com/jr). J Radiol84 (2003) 1933Search in Google Scholar
10 Glick PL, MR Harrison, DK Nakayama: Management of ventriculomegaly in the fetus. J Pediatr105 (1984) 97Search in Google Scholar
11 Greco P, M Resta, A Vimercati, et al.: Antenatal diagnosis of isolated lissencephaly by ultrasound and magnetic resonance imaging. Ultrasound Obstet Gynecol12 (1998) 276Search in Google Scholar
12 Gupta JK, FC Bryce, RJ Lilford: Management of apparently isolated fetal ventriculomegaly. Obstet Gynecol Surv49 (1994) 716Search in Google Scholar
13 Kim TH, JH Joh, MY Kim, YM Kim, KS Han: Fetal pericallosal lipoma: US and MR findings. Korean J Radiol3 (2002) 140Search in Google Scholar
14 Levene MI: Measurement of the growth of the lateral ventricles in preterm infants with real-time ultrasound. Arch Dis Child56 (1981) 90010.1136/adc.56.12.900Search in Google Scholar PubMed PubMed Central
15 Malinger G, D Lev, N Zahalka, et al.: Fetal cytomegalovirus infection of the brain: the spectrum of sonographic findings. Am J Neuroradiol24 (2003) 28Search in Google Scholar
16 Murphy MF, H Hambley, K Nicolaides, AH Waters: Severe fetomaternal alloimmune thrombocytopenia presenting with fetal hydrocephalus. Prenat Diagn16 (1996) 1152Search in Google Scholar
17 Nicolaides KH, S Berry, RJ Snijders, JG Thorpe-Beeston, C Gosden: Fetal lateral cerebral ventriculomegaly: associated malformations and chromosomal defects. Fetal Diagn Ther5 (1990) 5Search in Google Scholar
18 Signorelli M, A Tiberti, D Valseriati, et al.: Width of the fetal lateral ventricular atrium between 10 and 12 mm: a simple variation of the norm?Ultrasound Obstet Gynecol23 (2004) 14Search in Google Scholar
© by Walter de Gruyter Berlin New York
