Abstract
Objectives
N6-methyladenosine (m6A) is one of the most common epigenetic modifications of eukaryotic RNA. Under the jointly reversible regulation of related enzymes, m6A regulates many aspects of RNA, such as translation, stability and degradation. The aim of this study is to investigate the role of m6A in placenta-related diseases.
Methods
Data were compiled from 2018 to 2021 citations in PubMed and Google Scholar using the keywords: placenta AND N6-methyladenosine. Seven studies were included.
Results
In this study, we introduced some conventional methods to detect m6A modification at the whole RNA, region (peak) and single base levels. We also summarized the current studies of m6A modification in the placenta and briefly describe m6A in placental-related diseases, including recurrent miscarriage (RM), preeclampsia (PE) and gestational diabetes mellitus (GDM).
Conclusions
Although the relevant reports are still in the preliminary stage and some results are inconsistent, studies on methylation m6A modification have contributed new ideas for the research of reproductive diseases, providing a new basis for the diagnosis, treatment, prognosis and monitoring of related diseases.
Funding source: Talents Training Program of Changzhou Health Commission
Award Identifier / Grant number: CZQM2020103
Award Identifier / Grant number: CZQM2020095
Funding source: Science and technology project for young talents of Changzhou Health Commission
Award Identifier / Grant number: QN202048
Funding source: Natural Science Foundation of Jiangsu Province
Award Identifier / Grant number: BK20201158
Funding source: General project of Jiangsu Provincial Health Commission
Award Identifier / Grant number: M2021079
Acknowledgments
We thank all authors for their contributions.
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Research funding: This work was supported by grants for Talents Training Program of Changzhou Health Commission (CZQM2020103, CZQM2020095); Science and technology project for young talents of Changzhou Health Commission (QN202048); Natural Science Foundation of Jiangsu Province (BK20201158); General project of Jiangsu Provincial Health Commission (M2021079).
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Not applicable.
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Ethical approval: The local Institutional Review Board deemed the study exempt from review.
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