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Licensed Unlicensed Requires Authentication Published by De Gruyter June 26, 2006

The kallikrein world: an update on the human tissue kallikreins

  • Miltiadis Paliouras and Eleftherios P. Diamandis
From the journal Biological Chemistry

Abstract

Human tissue kallikreins (hKs) are attracting increased attention owing to their association with various forms of cancer and other diseases. Human tissue kallikrein genes represent the largest contiguous group of proteases within the human genome. There are many areas of kallikrein research that need to be further explored, including their tissue expression patterns, their regulation, identification of specific substrates, their participation in proteolytic cascades, and their clinical applicability as cancer biomarkers and therapeutic targets. In this review, we briefly describe the current status of kallikrein research and identify future avenues that will enhance our understanding of their function and involvement in human diseases.

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Corresponding author

References

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Published Online: 2006-06-26
Published in Print: 2006-06-01

©2006 by Walter de Gruyter Berlin New York

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