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Licensed Unlicensed Requires Authentication Published by De Gruyter January 30, 2015

Immunoglobulin IgA, IgD, IgG, IgM and IgG subclass reference values in adults

  • Bénédicte Puissant-Lubrano , Michael Peres , Pol-André Apoil , Nicolas Congy-Jolivet , Francis Roubinet and Antoine Blancher EMAIL logo

Corresponding author: Pr. Antoine Blancher, Laboratoire d’Immunologie du CHU de Toulouse, Hôpital Rangueil, TSA 50032, 31059 Toulouse Cedex 9, France, Phone: +33 5 61 323432, Fax: +33 5 61 323424, E-mail: ; and Laboratoire d’Immunogénétique Moléculaire, EA 3034, Université Paul Sabatier, Toulouse III, France

Acknowledgments

The authors thank The Binding Site for providing reagents. They are also grateful to Christine Taureau, Christine Bousquet, Audrey Dauba, Clarisse Benard and Jasmine Chauzeix for their excellent technical assistance.

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Financial support: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Funding: The Binding Site (Grant/Award Number: ‘The Binding Site provided reagents’).

References

1. Conley ME, Notarangelo LD, Etzioni A. Diagnostic criteria for primary immunodeficiencies. Clin Immunol 1999;93:190–7.10.1006/clim.1999.4799Search in Google Scholar

2. Bonagura VR. Using intravenous immunoglobulin (IVIG) to treat patients with primary immune deficiency disease. J Clin Immunol 2013;33(Suppl 2):S90–4.10.1007/s10875-012-9838-1Search in Google Scholar

3. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 2003;121: 749–57.10.1046/j.1365-2141.2003.04355.xSearch in Google Scholar

4. Vladutiu AO. Immunoglobulin D: properties, measurement, and clinical relevance. Clin Diag Lab Immunol 2000;7:131–40.10.1128/CDLI.7.2.131-140.2000Search in Google Scholar

5. Thevenet I, Benat C, Chauzeix J, Blancher A, Puissant-Lubrano B. Analytical performances of SPAplus turbidimeter for the dosage of immunoglobulins and beta-2 microglobulin in serum. Ann Biol Clin (Paris) 2014;72:423–34.10.1684/abc.2014.0974Search in Google Scholar

6. Butts WC, James GE, Keuhneman M. Intra-individual variation in the concentrations of IgA, IgG, IgM, and complement component C3 in serum of a normal adult population. Clin Chem 1977;23:511–4.10.1093/clinchem/23.3.511Search in Google Scholar

7. Lu H, Wang M, Gunsolley JC, Schenkein HA, Tew JG. Serum immunoglobulin G subclass concentrations in periodontally healthy and diseased individuals. Infect Immun 1994;62:1677–82.10.1128/iai.62.5.1677-1682.1994Search in Google Scholar

8. Gonzalez-Quintela A, Alende R, Gude F, Campos J, Rey J, Meijide LM, et al. Serum levels of immunoglobulins (IgG, IgA, IgM) in a general adult population and their relationship with alcohol consumption, smoking and common metabolic abnormalities. Clin Exp Immunol 2008;151:42–50.10.1111/j.1365-2249.2007.03545.xSearch in Google Scholar

9. Mosedale DE, Sandhu MS, Luan J, Goodall M, Grainger DJ. A new sensitive and specific enzyme-linked immunosorbent assay for IgD. J Immunol Methods 2006;313:74–80.10.1016/j.jim.2006.03.012Search in Google Scholar

10. Ritchie RF, Palomaki GE, Neveux LM, Navolotskaia O, Ledue T, Craig WY. Reference distributions for immunoglobulins A, G and M: a practical, simple, and clinically relevant approach in a large cohort. J Clin Lab Anal 1998;12:363–70.10.1002/(SICI)1098-2825(1998)12:6<363::AID-JCLA6>3.0.CO;2-XSearch in Google Scholar

11. Wilson C, Ebling R, Henig C, Adler T, Nicolaevski R, Barak M, et al. Significant, quantifiable differences exist between IgG subclass standards WHO67/97 and ERM-DA470k and can result in different interpretation of results. Clin Biochem 2013;46:1751–5.10.1016/j.clinbiochem.2013.07.014Search in Google Scholar

12. Pieringer H, Parzer I, Wohrer A, Reis P, Oppl B, Zwerina J. IgG4-related disease: an orphan disease with many faces. Orphanet J Rare Dis 2014;9:110.10.1186/s13023-014-0110-zSearch in Google Scholar

13. Heiner DC, Myers A, Beck CS. Deficiency of IgG4: a disorder associated with frequent infections and bronchiectasis that may be familial. Clin Rev Allergy 1983;1:259–66.10.1007/BF02991161Search in Google Scholar

14. French MA, Harrison G. Serum IgG subclass concentrations in healthy adults: a study using monoclonal antisera. Clin Exp Immunol 1984;56:473–5.Search in Google Scholar

15. Aucouturier P, Lacombe C, Bremard C, Lebranchu Y, Seligmann M, Griscelli C, et al. Serum IgG subclass levels in patients with primary immunodeficiency syndromes or abnormal susceptibility to infections. Clin Immunol Immunopathol 1989;51:22–37.10.1016/0090-1229(89)90203-1Search in Google Scholar

16. Stanley PJ, Corbo G, Cole PJ. Serum IgG subclasses in chronic and recurrent respiratory infections. Clin Exp Immunol 1984;58:703–8.Search in Google Scholar

17. Fraser PA, Schur PH. Hypoimmunoglobulinemia D: frequency, family studies, and association with HLA. Clin Immunol Immunopathol 1981;19:67–74.10.1016/0090-1229(81)90048-9Search in Google Scholar

Received: 2014-12-2
Accepted: 2014-12-19
Published Online: 2015-1-30
Published in Print: 2015-11-1

©2015 by De Gruyter

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