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Licensed Unlicensed Requires Authentication Published by De Gruyter May 10, 2017

The biology of JC polyomavirus

  • Benedetta Assetta and Walter J. Atwood ORCID logo EMAIL logo
From the journal Biological Chemistry

Abstract

JC polyomavirus (JCPyV) is the causative agent of a fatal central nervous system demyelinating disease known as progressive multifocal leukoencephalopathy (PML). PML occurs in people with underlying immunodeficiency or in individuals being treated with potent immunomodulatory therapies. JCPyV is a DNA tumor virus with a double-stranded DNA genome and encodes a well-studied oncogene, large T antigen. Its host range is highly restricted to humans and only a few cell types support lytic infection in vivo or in vitro. Its oncogenic potential in humans has not been firmly established and the international committee on oncogenic viruses lists JCPyV as possibly carcinogenic. Significant progress has been made in understanding the biology of JCPyV and here we present an overview of the field and discuss some important questions that remain unanswered.

Acknowledgments

We thank Dan DiMaio, John Sedivy, Amanda Jamieson, Marco de Cecco, and members of the Atwood laboratory for critical comments during the preparation of this review. Work in the Atwood laboratory is supported by grants from the National Institutes of Health, numbers R01NS043097, P01NS065719, and P30GM103410.

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Received: 2016-12-29
Accepted: 2017-4-20
Published Online: 2017-5-10
Published in Print: 2017-7-26

©2017 Walter de Gruyter GmbH, Berlin/Boston

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