Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter February 14, 2015

Plant-derived natural medicines for the management of depression: an overview of mechanisms of action

  • Marzieh Sarbandi Farahani

    Marzieh Sarbandi Farahani is a Pharm.D student at Islamic Azad University. Her major field of interest is phytotherapy researches in the area of mental disorders including depression and anxiety. She is motivated in learning new skills in the field of pharmacology and pharmacotherapy as well. She also works as a community pharmacist.

    , Roodabeh Bahramsoltani

    Roodabeh Bahramsoltani is a senior student of Pharm.D at Tehran University of Medical Sciences (TUMS) with an interest in pharmacognosy, phytochemistry and traditional Iranian medicine as well as assessing the pharmacological activity of herbal extracts and plant metabolites. Also she enjoys working in areas of depression, burn and dermal injuries, and gastrointestinal disorders. She is a member of Iran pharmacists association and works as a hospital pharmacist in pharmacies under observation of TUMS.

    , Mohammad Hosein Farzaei

    Mohammad Hosein Farzaei took the degree of Pharm.D in 2010 from Kermanshah University of Medical Sciences and the PhD degree in Traditional Pharmacy in 2014 from Tehran University of Medical Sciences. Hitherto, he has published 17 scientific papers in international journals. He is a researcher at Department of Traditional Medicine and his research interest is complementary and alternative medicine, natural medicine, and phytotherapy.

    , Mohammad Abdollahi

    Mohammad Abdollahi holds a Doctor of Pharmacy and a Doctorate of Philosophy is a full Professor of Pharmacology and Toxicology. Currently he is Dean of Department of Toxicology and Pharmacology at the Faculty of Pharmacy, Tehran University of Medical Sciences. Mohammad Abdollahi is an expert in the field of Evidence-Based Medicine.

    and Roja Rahimi

    Roja Rahimi is Assistant Professor at Tehran University of Medical Sciences, Tehran, Iran. She received her Pharm.D in 2004 and Ph.D in Traditional Iranian Pharmacy from Tehran University of Medical Sciences, Iran in 2013. She is interested in medicinal and pharmacological aspects of plants. She has been published more than 50 papers in the field of pharmacology, phytomedicine and traditional Iranian medicine.

    EMAIL logo

Abstract

Depression is a serious widespread psychiatric disorder that affects approximately 17% of people all over the world. Exploring the neurological mechanisms of the antidepressant activity of plant-derived agents could have a crucial role in developing natural drugs for the management of depression. The aim of the present study is to review the neurological mechanisms of action of antidepressant plants and their constituents. For this purpose, electronic databases, including PubMed, Science Direct, Scopus, and Cochrane Library, were searched from 1966 to October 2013. The results showed that several molecular mechanisms could be proposed for the antidepressant activity of medicinal plants and their constituents. Hypericum species could normalize brain serotonin level. Liquiritin and isoliquiritin from Glycyrrhiza uralensis rhizome act via the noradrenergic system. Rosmarinus officinalis and curcumin from Curcuma longa interact with D1 and D2 receptors as well as elevate the brain dopamine level. Sida tiagii and Aloysia gratissima involve γ-aminobutyric acid and N-methyl-D-aspartate receptors, respectively. Fuzi polysaccharide-1 from Aconitum carmichaeli could affect brain-derived neurotrophic factor signaling pathways. Psoralidin from Psoralea corylifolia seed modulate the hypothalamic-pituitary-adrenal axis. The total glycosides of Paeonia lactiflora demonstrate an inhibitory effect on both subtypes of monoamine oxidase. 3,6′-Di-o-sinapoyl-sucrose and tenuifoliside A from Polygala tenuifolia exhibit cytoprotective effects on neuronal cells. Further preclinical and clinical trials evaluating their safety, bioefficacy, and bioavailability are suggested to prove the valuable role of natural drugs in the management of depressive disorders.


Corresponding author: Roja Rahimi, Department of Traditional Pharmacy, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran 1417653761, Iran, e-mail:
aThese authors contributed equally to this article.

About the authors

Marzieh Sarbandi Farahani

Marzieh Sarbandi Farahani is a Pharm.D student at Islamic Azad University. Her major field of interest is phytotherapy researches in the area of mental disorders including depression and anxiety. She is motivated in learning new skills in the field of pharmacology and pharmacotherapy as well. She also works as a community pharmacist.

Roodabeh Bahramsoltani

Roodabeh Bahramsoltani is a senior student of Pharm.D at Tehran University of Medical Sciences (TUMS) with an interest in pharmacognosy, phytochemistry and traditional Iranian medicine as well as assessing the pharmacological activity of herbal extracts and plant metabolites. Also she enjoys working in areas of depression, burn and dermal injuries, and gastrointestinal disorders. She is a member of Iran pharmacists association and works as a hospital pharmacist in pharmacies under observation of TUMS.

Mohammad Hosein Farzaei

Mohammad Hosein Farzaei took the degree of Pharm.D in 2010 from Kermanshah University of Medical Sciences and the PhD degree in Traditional Pharmacy in 2014 from Tehran University of Medical Sciences. Hitherto, he has published 17 scientific papers in international journals. He is a researcher at Department of Traditional Medicine and his research interest is complementary and alternative medicine, natural medicine, and phytotherapy.

Mohammad Abdollahi

Mohammad Abdollahi holds a Doctor of Pharmacy and a Doctorate of Philosophy is a full Professor of Pharmacology and Toxicology. Currently he is Dean of Department of Toxicology and Pharmacology at the Faculty of Pharmacy, Tehran University of Medical Sciences. Mohammad Abdollahi is an expert in the field of Evidence-Based Medicine.

Roja Rahimi

Roja Rahimi is Assistant Professor at Tehran University of Medical Sciences, Tehran, Iran. She received her Pharm.D in 2004 and Ph.D in Traditional Iranian Pharmacy from Tehran University of Medical Sciences, Iran in 2013. She is interested in medicinal and pharmacological aspects of plants. She has been published more than 50 papers in the field of pharmacology, phytomedicine and traditional Iranian medicine.

References

Abbas, G., Naqvi, S., Erum, S., Ahmed, S., Atta-ur, R., and Dar, A. (2013). Potential antidepressant activity of Areca catechu nut via elevation of serotonin and noradrenaline in the hippocampus of rats. Phytother. Res. 27, 39–45.10.1002/ptr.4674Search in Google Scholar PubMed

Adebiyi, R.A., Elsa, A.T., Agaie, B.M., and Etuk, E.U. (2006). Antinociceptive and antidepressant like effects of Securidaca longepedunculata root extract in mice. J. Ethnopharmacol. 107, 234–239.10.1016/j.jep.2006.03.017Search in Google Scholar PubMed

Agrawal, A., Mohan, M., Kasture, S., Foddis, C., Frau, M.A., Loi, M.C., and Maxia, A. (2011). Antidepressant activity of Ceratonia siliqua L. fruit extract, a source of polyphenols. Nat. Prod. Res. 25, 450–456.10.1080/14786419.2010.527447Search in Google Scholar PubMed

Badhe, S.R., Badhe, R.V., Ghaisas, M.M., Chopade, V.V., and Deshpande, A.D. (2010). Evaluations of antidepressant activity of Anacyclus pyrethrum root extract. Int. J. Green Pharm. 4, 79–82.10.4103/0973-8258.63880Search in Google Scholar

Barauna, S.C., Kaster, M.P., Heckert, B.T., Do Nascimento, K.S., Rossi, F.M., Teixeira, E.H., Cavada, B.S., Rodrigues, A.L., and Leal, R.B. (2006). Antidepressant-like effect of lectin from Canavalia brasiliensis (ConBr) administered centrally in mice. Pharmacol. Biochem. Behav. 85, 160–169.10.1016/j.pbb.2006.07.030Search in Google Scholar PubMed

Belmaker, R.H. and Agam, G. (2008). Major depressive disorder. N. Engl. J. Med. 358, 55–68.10.1056/NEJMra073096Search in Google Scholar PubMed

Bettio, L.E., Machado, D.G., Cunha, M.P., Capra, J.C., Missau, F.C., Santos, A.R., Pizzolatti, M.G., and Rodrigues, A.L. (2011). Antidepressant-like effect of extract from Polygala paniculata: involvement of the monoaminergic systems. Pharm. Biol. 49, 1277–1285.10.3109/13880209.2011.621958Search in Google Scholar PubMed

Bhattamisra, S.K., Khanna, V.K., Agrawal, A.K., Singh, P.N., and Singh, S.K. (2008). Antidepressant activity of standardised extract of Marsilea minuta Linn. J. Ethnopharmacol. 117, 51–57.10.1016/j.jep.2008.01.012Search in Google Scholar PubMed

Blier, P. and El Mansari, M. (2013). Serotonin and beyond: therapeutics for major depression. Phil. Trans. R. Soc. B 368, 20120536.10.1098/rstb.2012.0536Search in Google Scholar PubMed PubMed Central

Cai, B., Cui, C.B., Chen, Y.H., Xu, Y.K., Luo, Z.P., Yang, M., and Yao, Z.W. (1996). Antidepressant effect of inulin-type oligosaccharides from Morinda officinalis How in mice. Chin. J. Pharmacol. Toxicol. 10, 109–112.Search in Google Scholar

Calapai, G., Crupi, A., Firenzuoli, F., Inferrera, G., Ciliberto, G., Parisi, A., De Sarro, G., and Caputi, A.P. (2001a). Interleukin-6 involvement in antidepressant action of Hypericum perforatum. Pharmacopsychiatry 34, S8–S10.10.1055/s-2001-15507Search in Google Scholar PubMed

Calapai, G., Crupi, A., Firenzuoli, F., Inferrera, G., Squadrito, F., Parisi, A., De Sarro, G., and Caputi, A. (2001b). Serotonin, norepinephrine and dopamine involvement in the antidepressant action of Hypericum perforatum. Pharmacopsychiatry 34, 45–49.10.1055/s-2001-15180Search in Google Scholar PubMed

Campos, M.M., Fernandes, E.S., Ferreira, J., Santos, A.R., and Calixto, J.B. (2005). Antidepressant-like effects of Trichilia catigua (Catuaba) extract: evidence for dopaminergic-mediated mechanisms. Psychopharmacology 182, 45–53.10.1007/s00213-005-0052-1Search in Google Scholar PubMed

Capra, J.C., Cunha, M.P., Machado, D.G., Zomkowski, A.D., Mendes, B.G., Santos, A.R., Pizzolatti, M.G., and Rodrigues, A.L. (2010). Antidepressant-like effect of scopoletin, a coumarin isolated from Polygala sabulosa (Polygalaceae) in mice: evidence for the involvement of monoaminergic systems. Eur. J. Pharmacol. 643, 232–238.10.1016/j.ejphar.2010.06.043Search in Google Scholar PubMed

Chen, P.J., Hsieh, C.L., Su, K.P., Hou, Y.C., Chiang, H.M., Lin, I.H., and Sheen, L.Y. (2008). The antidepressant effect of Gastrodia elata Bl. on the forced-swimming test in rats. Am. J. Chin. Med. 36, 95–106.10.1142/S0192415X08005618Search in Google Scholar PubMed

Chen, P.J., Hsieh, C.L., Su, K.P., Hou, Y.C., Chiang, H.M., and Sheen, L.Y. (2009). Rhizomes of Gastrodia elata B(L) possess antidepressant-like effect via monoamine modulation in subchronic animal model. Am. J. Chin. Med. 37, 1113–1124.10.1142/S0192415X09007533Search in Google Scholar PubMed

Chowdhury, B., Bhattamisra, S.K., and Das, M.C. (2011). Involvement of monoaminergic system in antidepressant-like activity of Glycyrrhiza glabra root extracts in rat. Pharmacology online 2, 405–415.Search in Google Scholar

Colla, A.R., Machado, D.G., Bettio, L.E., Colla, G., Magina, M.D., Brighente, I.M., and Rodrigues, A.L. (2012). Involvement of monoaminergic systems in the antidepressant-like effect of Eugenia brasiliensis Lam. (Myrtaceae) in the tail suspension test in mice. J. Ethnopharmacol. 143, 720–731.10.1016/j.jep.2012.07.038Search in Google Scholar PubMed

Crupi, R., Abusamra, Y.A.K., Spina, E., and Calapai, G. (2013). Preclinical data supporting/refuting the use of Hypericum perforatum in the treatment of depression. CNS Neurol. Disord. Drug Targets 12, 474–486.10.2174/1871527311312040006Search in Google Scholar PubMed

Dasari, R., Sathyavathi, D., Belide, S.K., and Soumy, B.R. (2013). Pharmacological evaluation for antidepressant activity of Vanda spathulata in mice. Int. J. Pharm. Bio Sci. 4, P866–P872.Search in Google Scholar

Datusalia, A.K., Sharma, S., Kalra, P., and Samal, M.K. (2009). Antidepressant-like potential of Sida tiagii Bhandari fruits in mice. J. Health Sci. 55, 641–648.10.1248/jhs.55.641Search in Google Scholar

Dhingra, D. and Goyal, P.K. (2008a). Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of Tinospora cordifolia in mice. Indian J. Pharm. Sci. 70, 761–767.10.4103/0250-474X.49118Search in Google Scholar PubMed PubMed Central

Dhingra, D. and Goyal, P.K. (2008b). Inhibition of MAO and GABA: probable mechanisms for antidepressant-like activity of Nardostachys jatamansi DC. in mice. Indian J. Exp. Biol. 46, 212–218.Search in Google Scholar

Dhingra, D. and Kumar, V. (2007). Pharmacological evaluation for antidepressant-like activity of Asparagus racemosus Willd. in mice. Pharmacology online 3, 133–152.Search in Google Scholar

Dhingra, D. and Kumar, V, (2008). Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of garlic extract in mice. Indian J. Pharmacol. 40, 175–179.10.4103/0253-7613.43165Search in Google Scholar PubMed PubMed Central

Dhingra, D. and Sharma, A. (2006a). Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests. Prog. Neuropsychopharmacol. Biol. Psychiatry 30, 449–454.10.1016/j.pnpbp.2005.11.019Search in Google Scholar

Dhingra, D. and Sharma, A. (2006b). Antidepressant-like activity of n-hexane extract of nutmeg (Myristica fragrans) seeds in mice. J. Med. Food 9, 84–89.10.1089/jmf.2006.9.84Search in Google Scholar

Dhingra, D. and Valecha, R. (2007a). Evaluation of antidepressant-like activity of aqueous and ethanolic extracts of Terminalia bellirica Roxb. fruits in mice. Indian J. Exp. Biol. 45, 610–616.Search in Google Scholar

Dhingra, D. and Valecha, R. (2007b). Evaluation of the antidepressant-like activity of Convolvulus pluricaulis choisy in the mouse forced swim and tail suspension tests. Med. Sci. Monit. 13, BR155–BR161.Search in Google Scholar

Dhingra, D., Joshi, P., Gupta, A., and Chhillar, R. (2012). Possible involvement of monoaminergic neurotransmission in antidepressant-like activity of Emblica officinalis fruits in mice. CNS Neurosci. Ther. 18, 419–425.10.1111/j.1755-5949.2011.00256.xSearch in Google Scholar

Do Rego, J.C, Benkiki, N., Chosson, E., Kabouche, Z., Seguin, E., and Costentin, J. (2007). Antidepressant-like effect of hyperfoliatin, a polyisoprenylated phloroglucinol derivative from Hypericum perfoliatum (Clusiaceae) is associated with an inhibition of neuronal monoamines uptake. Eur. J. Pharmacol. 569, 197–203.10.1016/j.ejphar.2007.05.008Search in Google Scholar

Duman, R.S. and Voleti, B. (2012). Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents. Trends Neurosci. 35, 47–56.10.1016/j.tins.2011.11.004Search in Google Scholar

Dunlop, B.W. and Nemeroff, C.B. (2007). The role of dopamine in the pathophysiology of depression. Arch. Gen. Psychiatry 64, 327–337.10.1001/archpsyc.64.3.327Search in Google Scholar

Dwyer, A.V., Whitten, D.L., and Hawrelak, J.A. (2011). Herbal medicines, other than St. John’s wort, in the treatment of depression: a systematic review. Altern. Med. Rev. 16, 40–49.Search in Google Scholar

Ernst, E. (2002). The risk-benefit profile of commonly used herbal therapies: ginkgo, St. John’s wort, ginseng, Echinacea, saw palmetto, and kava. Ann. Intern. Med. 136, 42–53.10.7326/0003-4819-136-1-200201010-00010Search in Google Scholar

Farzaei, M.H., Abbasabadi, Z., Ardekani, M.R.S., Rahimi, R., and Farzaei, F. (2013). Parsley: a review of ethnopharmacology, phytochemistry and biological activities. J. Tradit. Chin. Med. 33, 815–826.10.1016/S0254-6272(14)60018-2Search in Google Scholar

Farzaei, M.H., Rahimi, R., Attar, F., Siavoshi, F., Saniee, P., Hajimahmoodi, M., Mirnezami, T., and Khanavi, M. (2014). Chemical composition, antioxidant and antimicrobial activity of essential oil and extracts of Tragopogon graminifolius, a medicinal herb from Iran. Nat. Prod. Commun. 9, 121–124.10.1177/1934578X1400900134Search in Google Scholar

Fava, M. and Kendler, K.S. (2000). Major depressive disorder. Neuron 28, 335–341.10.1016/S0896-6273(00)00112-4Search in Google Scholar

Freitas, A.E., Budni, J., Lobato, K.R., Binfare, R.W., Machado, D.G., Jacinto, J., Veronezi, P.O., Pizzolatti, M.G., and Rodrigues, A.L. (2010). Antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice: evidence for the involvement of the monoaminergic system. Prog. Neuropsychopharmacol. Biol. Psychiatry 34, 335–343.10.1016/j.pnpbp.2009.12.010Search in Google Scholar PubMed

Freitas, A.E., Machado, D.G., Budni, J., Neis, V.B., Balen, G.O., Lopes, M.W., de Souza, L.F., Veronezi, P.O., Heller, M., Micke, G.A., et al. (2013). Antidepressant-like action of the bark ethanolic extract from Tabebuia avellanedae in the olfactory bulbectomized mice. J. Ethnopharmacol. 145, 737–745.10.1016/j.jep.2012.11.040Search in Google Scholar PubMed

Guadarrama-Cruz, G., Alarcón-Aguilar, F.J., Vega-Avila, E., Vázquez-Palacios, G., and Bonilla-Jaime, H. (2012). Antidepressant-like effect of Tagetes lucida Cav. extract in rats: involvement of the serotonergic system. Am. J. Chin. Med. 40, 753–768.10.1142/S0192415X12500565Search in Google Scholar PubMed

Gaur, V., Bodhankar, S.L., Mohan, V., and Thakurdesai, P. (2012). Antidepressant-like effect of 4-hydroxyisoleucine from Trigonella foenum graecum L. seeds in mice. Biomed. Aging Pathol. 2, 121–125.10.1016/j.biomag.2012.07.002Search in Google Scholar

Goldberg, J.S., Bell, Jr., and C.E., Pollard, D.A. (2014). Revisiting the monoamine hypothesis of depression: a new perspective. Perspect. Med. Chem. 6, 1–8.10.4137/PMC.S11375Search in Google Scholar PubMed PubMed Central

Goncalves, A.E., Burger, C., Amoah, S.K., Tolardo, R., Biavatti, M.W., and de Souza, M.M. (2012). The antidepressant-like effect of Hedyosmum brasiliense and its sesquiterpene lactone, podoandin in mice: evidence for the involvement of adrenergic, dopaminergic and serotonergic systems. Eur. J. Pharmacol. 674, 307–314.10.1016/j.ejphar.2011.11.009Search in Google Scholar PubMed

Goulart, Y.C.F., Martins, J.V.C., Santos, A.R., Moreira, L.Y., Calixto, J.B., Cortez, D.A.G., and Audi, E.A. (2007). Involvement of serotonin in the antidepressant-like effect of extract from Kielmeyera coriacea stems. Pharm. Biol. 45, 169–175.10.1080/13880200701212981Search in Google Scholar

Gu, L., Liu, Y.J., Wang, Y.B., and Yi, L.T. (2012). Role for monoaminergic systems in the antidepressant-like effect of ethanol extracts from Hemerocallis citrina. J. Ethnopharmacol. 139, 780–787.10.1016/j.jep.2011.11.059Search in Google Scholar PubMed

Henderson, L., Yue, Q., Bergquist, C., Gerden, B., and Arlett, P. (2002). St John’s wort (Hypericum perforatum): drug interactions and clinical outcomes. Br. J. Clin. Pharmacol. 54, 349–356.10.1046/j.1365-2125.2002.01683.xSearch in Google Scholar PubMed PubMed Central

Hsu, L.C., Ko, Y.J., Cheng, H.Y., Chang, C.W., Lin, Y.C., Cheng, Y.H., Hsieh, M.T., and Peng, W.H. (2012). Antidepressant-like activity of the ethanolic extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the forced swimming test and in the tail suspension test in mice. Evid. Based Complement. Alternat. Med. 2012, 497302.Search in Google Scholar

Hu, Y., Liu, P., Guo, D.H., Rahman, K., Wang, D.X., and Xie, T.T. (2010). Antidepressant effects of the extract YZ-50 from Polygala tenuifolia in chronic mild stress treated rats and its possible mechanisms. Pharm. Biol. 48, 794–800.10.3109/13880200903280034Search in Google Scholar PubMed

Hu, Y., Liu, M., Liu, P., Guo, D.H., Wei, R.B., and Rahman, K. (2011). Possible mechanism of the antidepressant effect of 3,6′-disinapoyl sucrose from Polygala tenuifolia Willd. J. Pharm. Pharmacol. 63, 869–874.10.1111/j.2042-7158.2011.01281.xSearch in Google Scholar PubMed

Idayu, N.F., Hidayat, M.T., Moklas, M.A., Sharida, F., Raudzah, A.R., Shamima, A.R., and Apryani, E. (2011). Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression. Phytomedicine 18, 402–407.10.1016/j.phymed.2010.08.011Search in Google Scholar PubMed

Ji, C.X., Li, X.Y., Jia, S.B., Liu, L.L., Ge, Y.C., Yang, Q.X., and Zhang, J.J. (2012). The antidepressant effect of Cynanchum auriculatum in mice. Pharm. Biol. 50, 1067–1072.10.3109/13880209.2012.656848Search in Google Scholar PubMed

Kalueff, A.V. and Nutt, D.J. (2007). Role of GABA in anxiety and depression. Depress. Anxiety 24, 495–517.10.1002/da.20262Search in Google Scholar PubMed

Kessler, R., Berlund, P., Demler, O., Jin, R., Koretz, D., and Merikangas, K.R. (2003). The epidemiology of major depressive disorder: results for the National Comorbidity Survey Replication (NCS-R). J. Am. Med. Assoc. 289, 3095–3105.10.1001/jama.289.23.3095Search in Google Scholar PubMed

Khulbe, A., Pandey, S., and Sah, S.P. (2013). Antidepressant-like action of the hydromethanolic flower extract of Tagetes erecta L. in mice and its possible mechanism of action. Indian J. Pharmacol. 45, 386–390.10.4103/0253-7613.115026Search in Google Scholar PubMed PubMed Central

Kim, J.H., Kim, S.Y., Lee, S.Y., and Jang, C.G. (2007). Antidepressant-like effects of Albizzia julibrissin in mice: involvement of the 5-HT1A receptor system. Pharmacol. Biochem. Behav. 87, 41–47.10.1016/j.pbb.2007.03.018Search in Google Scholar PubMed

Kim, S.J., Lee, M.S., Kim, J.H., Lee, T.H., and Shim, I. (2013). Antidepressant-like effects of Lycii radicis cortex and betaine in the forced swimming test in rats. Biomol. Ther. 21, 79–83.10.4062/biomolther.2012.072Search in Google Scholar PubMed PubMed Central

Kosari-Nasab, M., Babri, S., FatehiGharehlar, L., Doosti, M.H., and Pakzad, S. (2013). Involvement of GABAergic system in regulation of the anxiolytic- and antidepressant-like effects of Scrophularia striata extract in rats. Pharm. Biol. 51, 581–588.10.3109/13880209.2012.749924Search in Google Scholar PubMed

Krishnan, V. and Nestler, E.J. (2008). The molecular neurobiology of depression. Nature 455, 894–902.10.1038/nature07455Search in Google Scholar PubMed PubMed Central

Kulkarni, S.K., Akula, K.K., and Deshpande, J. (2012). Evaluation of antidepressant-like activity of novel water-soluble curcumin formulations and St. John’s wort in behavioral paradigms of despair. Pharmacology 89, 83–90.10.1159/000335660Search in Google Scholar PubMed

Kwon, S., Lee, B., Kim, M., Lee, H., Park, H.J., and Hahm, D.H. (2010). Antidepressant-like effect of the methanolic extract from Bupleurum falcatum in the tail suspension test. Prog. Neuropsychopharmacol. Biol. Psychiatry 34, 265–270.Search in Google Scholar

Lee, S.A., Hong, S.S., Han, X.H., Hwang, J.S., Oh, G.J., Lee, K.S., Lee, M.K., Hwang, B.Y., and Ro, J.S. (2005). Piperine from the fruits of Piper longum with inhibitory effect on monoamine oxidase and antidepressant-like activity. Chem. Pharm. Bull. 53, 832–835.10.1248/cpb.53.832Search in Google Scholar PubMed

Lee, S., Kim, D.H., Lee, C.H., Jung, J.W., Seo, Y.T., Jang, Y.P., and Ryu, J.H. (2010). Antidepressant-like activity of the aqueous extract of Allium macrostemon in mice. J. Ethnopharmacol. 131, 386–395.10.1016/j.jep.2010.07.015Search in Google Scholar PubMed

Lee, M.S., Park, W.S., Kim, Y.H., Kwon, S.H., Jang, Y.J., Han, D., Morita, K., and Her, S. (2013). Antidepressant-like effects of cortex Mori radicis extract via bidirectional phosphorylation of glucocorticoid receptors in the hippocampus. Behav. Brain Res. 236, 56–61.10.1016/j.bbr.2012.08.028Search in Google Scholar PubMed

Leonard, B.E. (2001). Stress, norepinephrine and depression. J. Psychiatry Neurosci. 26, S11–S16.Search in Google Scholar

Li, J., Geng, D., Xu, J., Weng, L.J., Liu, Q., and Yi, L.T. (2013). Antidepressant-like effect of macranthol isolated from Illicium dunnianum tutch in mice. Eur. J. Pharmacol. 707, 112–119.10.1016/j.ejphar.2013.03.010Search in Google Scholar PubMed

Liu, P., Hu, Y., Guo, D.H., Wang, D.X., Tu, H.H., Ma, L., Xie, T.T., and Kong, L.Y. (2010). Potential antidepressant properties of Radix polygalae (Yuan Zhi). Phytomedicine 17, 794–799.10.1016/j.phymed.2010.01.004Search in Google Scholar PubMed

Liu, Y., Jia, G., Gou, L., Sun, L., Fu, X., Lan, N., Li, S., and Yin, X. (2013). Antidepressant-like effects of tea polyphenols on mouse model of chronic unpredictable mild stress. Pharmacol. Biochem. Behav. 104, 27–32.10.1016/j.pbb.2012.12.024Search in Google Scholar PubMed

Machado, D.G., Kaster, M.P., Binfare, R.W., Dias, M., Santos, A.R., Pizzolatti, M.G., Brighente, I.M., and Rodrigues, A.L. (2007). Antidepressant-like effect of the extract from leaves of Schinus molle L. in mice: evidence for the involvement of the monoaminergic system. Prog. Neuropsychopharmacol. Biol. Psychiatry 31, 421–428.10.1016/j.pnpbp.2006.11.004Search in Google Scholar PubMed

Machado, D.G., Bettio, L.E.B., Cunha, M.P., Santos, A.R.S., Pizzolatti, M.G., Brighente, I.M.C., and Rodrigues, A.L.S. (2008). Antidepressant-like effect of rutin isolated from the ethanolic extract from Schinus molle L. in mice: evidence for the involvement of the serotonergic and noradrenergic systems. Eur. J. Pharmacol. 587, 163–168.10.1016/j.ejphar.2008.03.021Search in Google Scholar PubMed

Machado, D.G., Bettio, L.E.B., Cunha, M.P., Capra, J.C., Dalmarco, J.B., Pizzolatti, M.G., and Rodrigues, A.L.S. (2009). Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: involvement of the monoaminergic system. Prog. Neuropsychopharmacol. Biol. Psychiatry 33, 642–650.10.1016/j.pnpbp.2009.03.004Search in Google Scholar PubMed

Machado, D.G., Neis, V.B., Balen, G.O., Colla, A., Cunha, M.P., Dalmarco, J.B., Pizzolatti, M.G., Prediger, R.D., and Rodrigues, A.L. (2012). Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L. in mice: evidence for the involvement of the dopaminergic system. Pharmacol. Biochem. Behav. 103, 204–211.10.1016/j.pbb.2012.08.016Search in Google Scholar PubMed

Mao, Q.Q., Ip, S.P., Tsai, S.H., and Che, C.T. (2008). Antidepressant-like effect of peony glycosides in mice. J. Ethnopharmacol. 119, 272–275.10.1016/j.jep.2008.07.008Search in Google Scholar PubMed

Mao, Q.Q., Ip, S.P., Ko, K.M., Tsai, S.H., and Che, C.T. (2009a). Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor. Prog. Neuropsychopharmacol. Biol. Psychiatry 33, 1211–1216.10.1016/j.pnpbp.2009.07.002Search in Google Scholar PubMed

Mao, Q.Q., Ip, S.P., Ko, K.M., Tsai, S.H., Xian, Y.F., and Che, C.T. (2009b). Effects of peony glycosides on mice exposed to chronic unpredictable stress: further evidence for antidepressant-like activity. J. Ethnopharmacol. 124, 316–320.10.1016/j.jep.2009.04.019Search in Google Scholar PubMed

Maric, N.P. and Adzic, M. (2013). Pharmacological modulation of HPA axis in depression – new avenues for potential therapeutic benefits. Psychiatr. Danub. 25, 299–305.Search in Google Scholar

Martijena, I.D., Garcia, D.A., Marin, R.H., Perillo, M.A., and Zygadlo, J.P. (1998). Anxiogenic-like and antidepressant-like effects of the essential oil from Tagetes minuta. Fitoterapia 69, 155–160.Search in Google Scholar

Martinez-Vazquez, M., Estrada-Reyes, R., Araujo Escalona, A.G., Ledesma Velazquez, I., Martinez-Mota, L., Moreno, J., and Heinze, G. (2012). Antidepressant-like effects of an alkaloid extract of the aerial parts of Annona cherimolia in mice. J. Ethnopharmacol. 139, 164–170.10.1016/j.jep.2011.10.033Search in Google Scholar PubMed

Momin, R. and Mohan, M. (2012). Involvement of central noradrenaline, serotonin and dopamine system in the antidepressant activity of fruits of Solanum torvum (Solanaceae). Nat. Prod. Res. 26, 416–422.10.1080/14786419.2010.495072Search in Google Scholar PubMed

Moret, C. and Briley, M. (2011). The importance of norepinephrine in depression. Neuropsychiatr. Dis. Treat. 7, 9.Search in Google Scholar

Muller, L.G., Salles, L.A., Stein, A.C., Betti, A.H., Sakamoto, S., Cassel, E., Vargas, R.F., von Poser, G.L., and Rates, S.M. (2012). Antidepressant-like effect of Valeriana glechomifolia Meyer (Valerianaceae) in mice. Prog. Neuropsychopharmacol. Biol. Psychiatry 36, 101–109.Search in Google Scholar

Muruganandam, A.V., Ghosal, S., and Bhattacharya, S.K. (1999). The role of xanthones in the antidepressant activity of Hypericum perforatum involving dopaminergic and serotonergic systems. Biog. Amines 15, 553–567.Search in Google Scholar

Nakazawa, T., Yasuda, T., and Ohsawa, K. (2003). Antidepressant-like effects of magnolol from Magnolia officinalis in the forced swimming test. Nat. Med. 57, 221–226.Search in Google Scholar

Otobone, F.J., Sela, V.R., Obici, S., Moreira, L.Y., Cortez, D.A.G., and Audi, E.A. (2007). Role of 5-HT1A receptors in antidepressant-like effect of dichloromethane fraction of Kielmeyera coriacea in rats subjected to the forced swim test. Indian J. Pharmacol. 39, 75–79.10.4103/0253-7613.32524Search in Google Scholar

Patel, J.S. and Galani, V.J. (2013). Investigation of noradrenaline and serotonin mediated antidepressant action of Mucuna pruriens (L) D.C seeds using various experimental models. Orient. Pharm. Exp. Med. 13, 143–148.10.1007/s13596-012-0089-8Search in Google Scholar

Paul, I.A. and Skolnick, P. (2003). Glutamate and depression: clinical and preclinical studies. Ann. N. Y. Acad. Sci. 1003, 250–272.10.1196/annals.1300.016Search in Google Scholar PubMed

Piato, Â.L., Detanico, B.C., Jesus, J.F., Lhullier, F.L.R., Nunes, D.S., and Elisabetsky, E. (2008). Effects of marapuama in the chronic mild stress model: further indication of antidepressant properties. J. Ethnopharmacol. 118, 300–304.10.1016/j.jep.2008.04.018Search in Google Scholar PubMed

Piato, Ă.L., Rizon, L.P., Martins, B.S., Nunes, D.S., and Elisabetsky, E. (2009). Antidepressant profile of Ptychopetalum olacoides Bentham (marapuama) in mice. Phytother. Res. 23, 519–524.10.1002/ptr.2664Search in Google Scholar

Potdar, V.H. and Kibile, S.J. (2011). Evaluation of antidepressant-like effect of Citrus maxima leaves in animal models of depression. Iran. J. Basic. Med. Sci. 14, 478–483.Search in Google Scholar

Rahimi, R. and Abdollahi, M. (2012). An update on the ability of St. John’s wort to affect the metabolism of other drugs. Expert Opin. Drug. Metab. Toxicol. 8, 691–708.10.1517/17425255.2012.680886Search in Google Scholar

Rahimi, R., Nikfar, S., and Abdollahi, M. (2009). Efficacy and tolerability of Hypericum perforatum in major depressive disorder in comparison with selective serotonin reuptake inhibitors: a meta-analysis. Prog. Neuropsychopharmacol. Biol. Psychiatry 33, 118–127.10.1016/j.pnpbp.2008.10.018Search in Google Scholar

Ren, L.X., Luo, Y.F., Li, X., Zuo, D.Y., and Wu, Y.L. (2006). Antidepressant-like effects of sarsasapogenin from Anemarrhena asphodeloides Bunge (Liliaceae). Biol. Pharm. Bull. 29, 2304–2306.10.1248/bpb.29.2304Search in Google Scholar

Risbrough, V.B. and Stein, M.B. (2006). Role of corticotropin releasing factor in anxiety disorder: a translational research perspective. Horm. Behav. 50, 550–561.10.1016/j.yhbeh.2006.06.019Search in Google Scholar

Rodrigues, A.L.S., da Silva, G.L., Mateussi, A.S., Fernandes, E.S., Miguel, O.G., Yunes, R.A., Calixto, J.B., and Santos, A.R.S. (2002). Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extract of Siphocampylus verticillatus. Life Sci. 70, 1347–1358.10.1016/S0024-3205(01)01498-9Search in Google Scholar

Rojas, P., Serrano-Garcia, N., Medina-Campos, O.N., Pedraza-Chaverri, J., Ogren, S.O., and Rojas, C. (2011). Antidepressant-like effect of a Ginkgo biloba extract (EGb761) in the mouse forced swimming test: role of oxidative stress. Neurochem. Int. 59, 628–636.10.1016/j.neuint.2011.05.007Search in Google Scholar PubMed

Sah, S.P., Mathela, C.S., and Chopra, K. (2011a). Antidepressant effect of Valeriana wallichii patchouli alcohol chemotype in mice: behavioural and biochemical evidence. J. Ethnopharmacol. 135, 197–200.10.1016/j.jep.2011.02.018Search in Google Scholar PubMed

Sah, S.P., Mathela, C.S., and Chopra, K. (2011b). Involvement of nitric oxide (NO) signalling pathway in the antidepressant activity of essential oil of Valeriana wallichii Patchouli alcohol chemotype. Phytomedicine 18, 1269–1275.10.1016/j.phymed.2011.06.009Search in Google Scholar PubMed

Sakakibara, H., Yoshino, S., Kawai, Y., and Terao, J. (2008). Antidepressant-like effect of onion (Allium cepa L.) powder in a rat behavioral model of depression. Biosci. Biotechnol. Biochem. 72, 94–100.10.1271/bbb.70454Search in Google Scholar PubMed

Sarris, J. (2013). St. John’s wort for the treatment of psychiatric disorders. Psychiatry Clin. North Am. 36, 65–72.10.1016/j.psc.2013.01.004Search in Google Scholar

Sarris, J., Panossian, A., Schweitzer, I., Stough, C., and Scholey, A. (2011). Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence. Eur. Neuropsychopharmacol. 21, 841–860.10.1016/j.euroneuro.2011.04.002Search in Google Scholar

Seol, G.H., Shim, H.S., Kim, P.J., Moon, H.K., Lee, K.H., Shim, I., Suh, S.H., and Min, S.S. (2010). Antidepressant-like effect of Salvia sclarea is explained by modulation of dopamine activities in rats. J. Ethnopharmacol. 130, 187–190.10.1016/j.jep.2010.04.035Search in Google Scholar

Shewale, P.B., Patil, R.A., and Hiray, Y.A. (2012). Antidepressant-like activity of anthocyanidins from Hibiscus rosasinensis flowers in tail suspension test and forced swim test. Indian J. Pharmacol. 44, 454–457.10.4103/0253-7613.99303Search in Google Scholar

Singh, G.K., Garabadu, D., Muruganandam, A.V., Joshi, V.K., and Krishnamurthy, S. (2009). Antidepressant activity of Asparagus racemosus in rodent models. Pharmacol. Biochem. Behav. 91, 283–290.10.1016/j.pbb.2008.07.010Search in Google Scholar

Stein, A.C., Viana, A.F., Muller, L.G., Nunes, J.M., Stolz, E.D., Do Rego, J.C., Costentin, J., von Poser, G.L., and Rates, S.M. (2012). Uliginosin B, a phloroglucinol derivative from Hypericum polyanthemum: a promising new molecular pattern for the development of antidepressant drugs. Behav. Brain Res. 228, 66–73.10.1016/j.bbr.2011.11.031Search in Google Scholar

Subarnas, A., Tadano, T., Nakahata, N., Arai, Y., Kinemuchi, H., Oshima, Y., Kisara, K., and Ohizumi, Y. (1993). A possible mechanism of antidepressant activity of b-amyrin palmitate isolated from Lobelia inflata leaves in the forced swimming test. Life Sci. 52, 289–296.10.1016/0024-3205(93)90220-WSearch in Google Scholar

Taciany Bonassoli, V., Micheli Chassot, J., Longhini, R., Milani, H., Mello, J.C.P., and De Oliveira, R.M.W. (2012). Subchronic administration of Trichilia catigua ethyl-acetate fraction promotes antidepressant-like effects and increases hippocampal cell proliferation in mice. J. Ethnopharmacol. 143, 179–184.10.1016/j.jep.2012.06.021Search in Google Scholar PubMed

Teixeira, C.P.L., De Melo, C.T.V., De Araújo, F.L.O., De Carvalho, A.M.R., Silva, M.I.G., Barbosa-Filho, J.M., Macêdo, D.S., De Barros Viana, G.S., and De Sousa, F.C.F. (2013). Antidepressant-like effect of riparin II from Aniba riparia in mice: evidence for the involvement of the monoaminergic system. Fundam. Clin. Pharmacol. 27, 129–137.10.1111/j.1472-8206.2011.00973.xSearch in Google Scholar PubMed

Trivedi, M.H., Fava, M., Wisniewski, S.R., Thase, M.E., Quitkin, F., Warden, D., Ritz L., Nierenberg, A.A., Lebowitz, B.D., and Biggs, M.M. (2006). Medication augmentation after the failure of SSRIs for depression. N. Engl. J. Med. 354, 1243–1252.10.1056/NEJMoa052964Search in Google Scholar PubMed

Viana, A., Do Rego, J.C., von Poser, G., Ferraz, A., Heckler, A.P., Costentin, J., and Kuze Rates, S.M. (2005). The antidepressant-like effect of Hypericum caprifoliatum Cham & Schlecht (Guttiferae) on forced swimming test results from an inhibition of neuronal monoamine uptake. Neuropharmacology 49, 1042–1052.10.1016/j.neuropharm.2005.06.002Search in Google Scholar

Victoria, F.N., De Siqueira Brahm, A., Savegnago, L., and Lenardão, E.J. (2013). Involvement of serotoninergic and adrenergic systems on the antidepressant-like effect of E. uniflora L. leaves essential oil and further analysis of its antioxidant activity. Neurosci. Lett. 544, 105–109.10.1016/j.neulet.2013.03.054Search in Google Scholar

Vollmayr, B., Mahlstedt, M.M., and Henn, F.A. (2007). Neurogenesis and depression: what animal models tell us about the link. Eur. Arch. Psychiatry Clin. Neurosci. 257, 300–303.10.1007/s00406-007-0734-2Search in Google Scholar

Wang, W., Hu, X., Zhao, Z., Liu, P., Hu, Y., Zhou, J., Zhou, D., Wang, Z., Guo, D., and Guo, H. (2008). Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice. Prog. Neuropsychopharmacol. Biol. Psychiatry 32, 1179–1184.10.1016/j.pnpbp.2007.12.021Search in Google Scholar

Xiang, H., Liu, Y., Zhang, B., Huang, J., Li, Y., Yang, B., Huang, Z., Xiang, F., and Zhang, H. (2011). The antidepressant effects and mechanism of action of total saponins from the caudexes and leaves of Panax notoginseng in animal models of depression. Phytomedicine 18, 731–738.10.1016/j.phymed.2010.11.014Search in Google Scholar

Xu, Q., Pan, Y., Yi, L.T., Li, Y.C., Mo, S.F., Jiang, F.X., Qiao, C.F., Xu, H.X., Lu, X.B., Kong, L.D., et al. (2008a). Antidepressant-like effects of psoralen isolated from the seeds of Psoralea corylifolia in the mouse forced swimming test. Biol. Pharm. Bull. 31, 1109–1114.10.1248/bpb.31.1109Search in Google Scholar

Xu, Q., Yi, L.T., Pan, Y., Wang, X., Li, Y.C., Li, J.M., Wang, C.P., and Kong, L.D. (2008b). Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents. Prog. Neuropsychopharmacol. Biol. Psychiatry 32, 715–725.10.1016/j.pnpbp.2007.11.020Search in Google Scholar

Yamaura, K., Nakayama, N., Shimada, M., Bi, Y., Fukata, H., and Ueno, K. (2012). Antidepressant-like effects of young green barley leaf (Hordeum vulgare L.) in the mouse forced swimming test. Pharmacogn. Res. 4, 22–26.10.4103/0974-8490.91030Search in Google Scholar

Yan, H.C., Qu, H.D., Sun, L.R., Li, S.J., Cao, X., Fang, Y.Y., Jie, W., Bean, J.C., Wu, W.K., Zhu, X.H., et al. (2010). Fuzi polysaccharide-1 produces antidepressant-like effects in mice. Int. J. Neuropsychopharmacol. 13, 623–633.10.1017/S1461145709990733Search in Google Scholar

Yao, Y., Sang, W., Yang, X.S., Zhai, M.J., Wang, L.L., Qin, P.Y., Wu, L., Zhou, X.R., Wang, L.J., Li, J.Y., et al. (2012). antidepressant effects of ginsenosides from Panax notoginseng. J. Integr. Agric. 11, 483–488.10.1016/S2095-3119(12)60034-3Search in Google Scholar

Ye, L., Hu, Z., Du, G., Zhang, J., Dong, Q., Fu, F., and Tian, J. (2012). Antidepressant-like effects of the extract from Cimicifuga foetida L. J. Ethnopharmacol. 144, 683–691.10.1016/j.jep.2012.10.013Search in Google Scholar

Yi, L.T., Li, Y.C., Pan, Y., Li, J.M., Xu, Q., Mo, S.F., Qiao, C.F., Jiang, F.X., Xu, H.X., Lu, X.B., et al. (2008). Antidepressant-like effects of psoralidin isolated from the seeds of Psoralea corylifolia in the forced swimming test in mice. Prog. Neuropsychopharmacol. Biol. Psychiatry 32, 510–519.Search in Google Scholar

Youdim, M.B., Edmondson, D., and Tipton, K.F. (2006). The therapeutic potential of monoamine oxidase inhibitors. Nat. Rev. Neurosci. 7, 295–309.10.1038/nrn1883Search in Google Scholar

Yu, H. and Chen, Z.Y. (2010). The role of BDNF in depression on the basis of its location in the neural circuitry. Acta Pharmacol. Sin. 32, 3–11.10.1038/aps.2010.184Search in Google Scholar

Yu, Z.F., Kong, L.D., and Chen, Y. (2002). Antidepressant activity of aqueous extracts of Curcuma longa in mice. J. Ethnopharmacol. 83, 161–165.10.1016/S0378-8741(02)00211-8Search in Google Scholar

Zeni, A.L., Zomkowski, A.D., Dal-Cim, T., Maraschin, M., Rodrigues, A.L., and Tasca, C.I. (2011). Antidepressant-like and neuroprotective effects of Aloysia gratissima: investigation of involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway. J. Ethnopharmacol. 137, 864–874.10.1016/j.jep.2011.07.009Search in Google Scholar PubMed

Zeni, A.L.B., Zomkowski, A.D.E., Maraschin, M., Tasca, C.I., and Rodrigues, A.L.S. (2013). Evidence of the involvement of the monoaminergic systems in the antidepressant-like effect of Aloysia gratissima. J. Ethnopharmacol. 148, 914–920.10.1016/j.jep.2013.05.042Search in Google Scholar PubMed

Zhang, Y.J., Huang, W., Huang, X., Wang, Y., Wang, Z., Wang, C., Zhong, B.W., Sheng, C.X., Wang, B., Zhang, S.F., et al. (2012). Fructus aurantii induced antidepressant effect via its monoaminergic mechanism and prokinetic action in rat. Phytomedicine 19, 1101–1107.10.1016/j.phymed.2012.05.015Search in Google Scholar PubMed

Zheng, M., Liu, C., Fan, Y., and Shi, D. (2012). Involvement of serotonergic system in the antidepressant-like effect of hyperoside from Apocynum venetum leaves. Lat. Am. J. Pharm. 31, 984–989.Search in Google Scholar

Zheng, M., Fan, Y., Shi, D., and Liu, C. (2013). Antidepressant-like effect of flavonoids extracted from Apocynum venetum leaves on brain monoamine levels and dopaminergic system. J. Ethnopharmacol. 147, 108–113.10.1016/j.jep.2013.02.015Search in Google Scholar PubMed

Zhu, W., Ma, S., Qu, R., Kang, D., and Liu, Y. (2006). Antidepressant effect of baicalin extracted from the root of Scutellaria baicalensis in mice and rats. Pharm. Biol. 44, 503–510.10.1080/13880200600878684Search in Google Scholar

Zhu, W.L., Shi, H.S., Wei, Y.M., Wang, S.J., Sun, C.Y., Ding, Z.B., and Lu, L. (2012). Green tea polyphenols produce antidepressant-like effects in adult mice. Pharmacol. Res. 65, 74–80.10.1016/j.phrs.2011.09.007Search in Google Scholar PubMed

Received: 2014-8-11
Accepted: 2014-11-5
Published Online: 2015-2-14
Published in Print: 2015-6-1

©2015 by De Gruyter

Downloaded on 27.4.2024 from https://www.degruyter.com/document/doi/10.1515/revneuro-2014-0058/html
Scroll to top button