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Therapeutic potential of nanoceria in regenerative medicine

  • Biological Interactions of Oxide Nanoparticles: The Good and The Evil
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Abstract

Tissue engineering and regenerative medicine aim to achieve functional restoration of tissue or cells damaged through disease, aging, or trauma. Advancement of tissue engineering requires innovation in the field of three-dimensional scaffolding and functionalization with bioactive molecules. Nanotechnology offers advanced materials with patterned nano-morphologies for cell growth and different molecular substrates that can support cell survival and functions. Cerium oxide nanoparticles (nanoceria) can control intracellular as well as extracellular reactive oxygen and nitrogen species. Recent findings suggest that nanoceria can enhance long-term cell survival, enable cell migration and proliferation, and promote stem cell differentiation. Moreover, the self-regenerative property of nanoceria permits a small dose to remain catalytically active for an extended time. This review summarizes the possibilities and applications of nanoceria in the field of tissue engineering and regenerative medicine.

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Acknowledgements

This work was supported, in part, by the intramural research program of the National Institute on Aging. The work by J.F.M. was supported by NIH NEI Grant COBRE-P20 RR017703, P30-EY 12190, R21EY018306, R01EY18724, R01EY022111; National Science Foundation: CBET-0708172; and Research to Prevent Blindness. D.R.B. was supported by the NIEHS Center Grant U19 ES019544. Part of this work was performed using EMSL, a national scientific user facility sponsored by the US Department of Energy, Biological and Environmental Research and located at PNNL. S.S. and W.S. acknowledge NSF and NIH for various aspects of nano-biotechnology research.

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Authors and Affiliations

  1. Advanced Materials Processing Analysis Center, Nanoscience Technology Center, University of Central Florida, USA

    Soumen Das

  2. Division of Neurotoxicology, US Food and Drug Administration, National Center for Toxicological Research, USA

    Srinivasulu Chigurupati

  3. Burnett School of Biomedical Science, University of Central Florida, USA

    Janet Dowding & William Self

  4. Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, USA

    Prabhakaran Munusamy & Donald R. Baer

  5. Department of Ophthalmology, University of Oklahoma Health Sciences Center, USA

    James F. McGinnis

  6. Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, USA

    Mark P. Mattson

  7. Advanced Materials Processing and Analysis Center, Nanoscience and Technology Center, Mater. Sci. Eng., College of Medicine, University of Central Florida, USA

    Sudipta Seal

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  1. Soumen Das
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Das, S., Chigurupati, S., Dowding, J. et al. Therapeutic potential of nanoceria in regenerative medicine. MRS Bulletin 39, 976–983 (2014). https://doi.org/10.1557/mrs.2014.221

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