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Changes of tear film and tear secretion after phacoemulsification in diabetic patients

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Abstract

Objective

To evaluate tear film stability and tear secretion in patients with diabetes after phacoemulsification.

Methods

Twenty-five diabetic cataract patients and 20 age-matched non-diabetic cataract patients as control underwent phacoemulsification. Tear film break-up time (TFBUT), Schirmer I test (SIT), corneal fluorescein staining, and dry eye symptoms were measured pre-and postoperatively.

Results

Diabetics had a decreased preoperative TFBUT and SIT. TFBUT was reduced on Day 1 and recovered on Day 180 postoperatively in both groups. SIT was increased after phacoemulsification, but returned to preoperative levels by Day 180 in non-diabetics, whereas it was lower than preoperative level in diabetics. Positive corneal fluorescein staining was elevated in both groups, and returned to preoperative levels only in controls. Dry eye symptoms were similar to fluorescein staining in both groups.

Conclusion

Tear secretion was reduced in diabetic cataract patients after phacoemulsification, which worsened dry eye symptoms and predisposed those patients to ocular damage.

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References

  • Antcliff, R.J., Poulson, A., Flanagan, D.W., 1996. Phacoemulsification in diabetics. Eye, 10(6):737–741.

    PubMed  Google Scholar 

  • Blades, K.J., Patel, S., Aidoo, K.E., 2001. Oral antioxidant therapy for marginal dry eye. Eur. J. Clin. Nutr., 55(7):589–597. [doi:10.1038/sj.ejcn.1601186]

    Article  PubMed  CAS  Google Scholar 

  • Dandona, P., Thusu, K., Cook, S., Snyder, B., Makowski, J., Armstrong, D., Nicotera, T., 1996. Oxidative damage to DNA in diabetes mellitus. Lancet, 347(8999):444–445. [doi:10.1016/S0140-6736(96)90013-6]

    Article  PubMed  CAS  Google Scholar 

  • Dogru, M., Katakami, C., Inoue, M., 2001. Tear function and ocular surface changes in noninsulin-dependent diabetes mellitus. Ophthalmology, 108(3):586–592. [doi:10.1016/S0161-6420(00)00599-6]

    Article  PubMed  CAS  Google Scholar 

  • Goebbels, M., 2000. Tear secretion and tear film function in insulin dependent diabetics. Br. J. Ophthalmol., 84(1):19–21. [doi:10.1136/bjo.84.1.19]

    Article  PubMed  CAS  Google Scholar 

  • Hamilton, A.M.P., Ulbig, M.W., Polkinghorne, P., 1996. Epidemiology of Diabetic Retinopathy. In: Hamilton, A.M.P., Ulbig, M.W., Polkinghorne, P. (Eds.), Management of Diabetic Retinopathy. B.M.J. Publishing Group, London, p.1–15.

    Google Scholar 

  • Klein, B.E., Klein, R., Moss, S.E., 1985. Prevalence of cataracts in a population-based study of persons with diabetes mellitus. Ophthalmology, 92(6):1191–1196.

    PubMed  CAS  Google Scholar 

  • Liu, Z., Luo, L., Zhang, Z., Cheng, B., Zheng, D., Chen, W., Lin, Z., Yang, W., Liu, Y., Zhang, M., Xiao, Q., Chen, J., 2002. Tear film changes after phacoemulsification. Zhonghua Yan Ke Za Zhi, 38(5):274–277 (in Chinese).

    PubMed  Google Scholar 

  • Ozdemir, M., Buyukbese, M.A., Cetinkaya, A., Ozdemir, G., 2003. Risk factors for ocular surface disorders in patients with diabetes mellitus. Diabetes Res. Clin. Pract., 59(3):195–199. [doi:10.1016/S0168-8227(02)00244-9]

    Article  PubMed  CAS  Google Scholar 

  • Peponis, V., Papathanasiou, M., Kapranou, A., Magkou, G., Tyligada, A., Melidonis, A., Drosos, T., Sitaras, N.M., 2002. Protective role of oral antioxidant supplementation in ocular surface of diabetic patients. Br. J. Ophthalmol., 86(12):1369–1373. [doi:10.1136/bjo.86.12.1369]

    Article  PubMed  CAS  Google Scholar 

  • Ram, J., Gupta, A., Brar, G., Kaushik, S., Gupta, A., 2002. Outcomes of phacoemulsification in patients with dry eye. J. Cataract Refract. Surg., 28(8):1386–1389. [doi:10.1016/S0886-3350(02)01387-1]

    Article  PubMed  Google Scholar 

  • Takahashi, H., 2005. Free radical development in phacoemulsification cataract surgery. J. Nippon Med. Sch., 72(1):4–12. [doi:10.1272/jnms.72.4]

    Article  PubMed  CAS  Google Scholar 

  • Yan, S.D., Schmidt, A.M,, Anderson, G.M., Zhang, J., Brett, J., Zou, Y.S., Pinsky, D., Stern, D., 1994. Enhanced cellular oxidant stress by the interaction of advanced glycation and products with their receptors/binding proteins. J. Biol. Chem., 269(13):9889–9897.

    PubMed  CAS  Google Scholar 

  • Zaczek, A., Zetterstrom, C., 1998. Aqueous flare intensity after phacoemulsification in patients with diabetes mellitus. J. Cataract Refract. Surg., 24(8):1099–1104.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Ophthalmology Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China

    Xi LIU, Yang-shun GU & Ye-sheng Xu

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  1. Xi LIU
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  2. Yang-shun GU
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  3. Ye-sheng Xu
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Correspondence to Yang-shun GU.

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LIU, X., GU, Ys. & Xu, Ys. Changes of tear film and tear secretion after phacoemulsification in diabetic patients. J. Zhejiang Univ. Sci. B 9, 324–328 (2008). https://doi.org/10.1631/jzus.B0710359

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  • DOI: https://doi.org/10.1631/jzus.B0710359

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