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Interleukin-17 and acute coronary syndrome

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Abstract

Inflammation plays an important role in atherosclerosis, which is also crucial for acute coronary syndrome (ACS). Recent studies have revealed that interleukin (IL)-17, which was regarded as a pro-inflammatory cytokine, has a dual function in the progress of ACS. In this review, we sum up both experimental and clinical studies on the relevance of IL-17 to atherosclerosis and its complications, and summarize the research progress on the effect of IL-17 on the atherosclerotic plaque stability and ACS onset. Although the studies are controversial and the mechanism remains unclear, we highlight the knowledge of the role of IL-17 in ACS and elucidate its potential mechanism.

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  1. Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China

    Sheng-an Su, Hong Ma, Li Shen, Mei-xiang Xiang & Jian-an Wang

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  1. Sheng-an Su
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  2. Hong Ma
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  3. Li Shen
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  4. Mei-xiang Xiang
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Correspondence to Mei-xiang Xiang.

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Project (No. 81270127) supported by the National Natural Science Foundation of China

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Su, Sa., Ma, H., Shen, L. et al. Interleukin-17 and acute coronary syndrome. J. Zhejiang Univ. Sci. B 14, 664–669 (2013). https://doi.org/10.1631/jzus.BQICC701

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