Skip to main content
SpringerLink
Log in

Nutritional Recommendations for Diabetic Patients and Treatment with α-Glucosidase Inhibitors

  • Published:
Drugs Aims and scope Submit manuscript

Summary

Adjunctive treatment with acarbose (possibly together with sulphonylurea or insulin treatment) can be effectively utilised to achieve blood glucose control if postprandial hyperglycaemia is a problem and cannot be sufficiently controlled by dietary modifications. The α-glucosidase inhibitor, acarbose, should be taken with meals that are rich in complex carbohydrates and low in simple sugars, as recommended by diabetes associations, to achieve the greatest possible benefit from treatment

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Alberti KGMM, Gries FA, European NIDDM Policy Group. Management of non-insulin-dependent diabetes mellitus in Europe: a consensus view. Diabetic Medicine 5: 275–281, 1988

    Article  PubMed  CAS  Google Scholar 

  • American Diabetes Association. Nutritional recommendations and principles for individuals with diabetes mellitus (1986 Position Statement). Diabetes Care 10: 126–132, 1987

    Google Scholar 

  • American Diabetes Association. Physician’s guide to non-insulin-dependent (type II) diabetes, 2nd ed., pp. 26–34, ADA, Alexandria, 1988a

    Google Scholar 

  • American Diabetes Association. Physician’s guide to insulin-dependent (type 1) diabetes, 2nd ed., pp. 46–53, ADA, Alexandria, 1988b

    Google Scholar 

  • Beyer J, Schulz G, Jager H, Krause U, Cordes U. Improvement of carbohydrate tolerance in insulin dependent diabetics after administration of an α-glucosidase inhibitor demonstrated by artificial pancreas. In Creutzfeldt W (Ed.) Acarbose: effect on carbohydrate and fat metabolism, pp. 451–454, Excerpta Medica, Amsterdam, 1981

    Google Scholar 

  • Caspary WF. Sucrose-malabsorption in man after ingestion of α-glucosidase hydrolase inhibitor. Lancet 1: 1231–1233, 1978

    Article  PubMed  CAS  Google Scholar 

  • Caspary WF. Inhibitors influencing carbohydrate absorption. In Creutzfeldt W, Lefèbvre P (Eds) Diabetes mellitus, patho-physiology and therapy, pp. 172–191, Springer, New York, 1989

    Chapter  Google Scholar 

  • Clissold SP, Edwards C. Acarbose, a preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential. Drugs 35: 214–243, 1988

    Article  PubMed  CAS  Google Scholar 

  • Coulston AM, Hollenbeck CB, Swislocki AM, Reaven GM. Effect of source of dietary carbohydrate on plasma glucose and insulin response to mixed meals in subjects with NIDDM. Diabetes Care 10: 395–400, 1987

    Article  PubMed  CAS  Google Scholar 

  • Diabetes and Nutrition Study Group of the European Association for the Study of Diabetes: statement. Nutritional recommendations for individuals with diabetes mellitus. Diabetes, Nutrition and Metabolism. Clinical and Experimental 1: 145–149, 1988

    Google Scholar 

  • Elsenhaus B, Caspary WF. Absorption of carbohydrates. In Caspary WF (Ed.) Structure and function of the small intestine, pp. 139–163, Excerpta Medica, Amsterdam, 1987

    Google Scholar 

  • European NIDDM Policy Group. A desktop guide for the management of non-insulin-dependent diabetes mellitus (NIDDM). IDF Bulletin 35 (Suppl.): 1–23, 1990

    Google Scholar 

  • Gérard J, Luyckx AS, Lefèbvre P. Improvement of metabolic control in insulin dependent diabetes treated with the alphaglucosidase inhibitor acarbose for two months. Diabetologia 21: 446–457, 1981

    Article  PubMed  Google Scholar 

  • Hanefeld M, Fischer S, Schulze J, Spengler M, Wargenau M, et al. Therapeutic potentials of acarbose as first-line drug in NIDDM insufficiently treated with diet alone. Diabetes Care 14: 732–739, 1991

    Article  PubMed  CAS  Google Scholar 

  • Jenkins DJA, Jenkins AL, Wolever TMS, Vuksan V, Wong GS, et al. Aims of diet in diabetes management. In Creutzfeldt W, Lefèbvre P (Eds) Diabetes mellitus: pathophysiology and therapy, Springer, New York, 1988

    Google Scholar 

  • Leonardt W, Hanefeld M, Fischer S, Schultz J, Spengler M. Beneficial effects on serum lipids in non insulin dependent diabetics by acarbose treatment. Arzneimittel-Forshung 41: 735–738, 1991

    Google Scholar 

  • Mann JI. Simple sugars and diabetes. Diabetic Medicine 4: 135–139, 1987

    Article  PubMed  CAS  Google Scholar 

  • Müller L. Chemistry, biochemistry and therapeutic potential of microbial α-glucosidase inhibitors. In Demain et al. (Eds) Novel microbial products for medicine and agriculture, pp. 109-166, Society for Industrial Microbiology, 1989

  • Puls W, Bischoff H. The pharmacological rationale of diabetes mellitus therapy with acarbose. In Creutzfeldt W (Ed.) Acarbose for the treatment of diabetes mellitus, pp. 36–38, Springer, Berlin, 1988

    Google Scholar 

  • Puls W, Keup U, Krause HP, Müller L, Schmidt DD, et al. Pharmacology of α-glucosidase inhibitors. Frontiers of Hormone Research 7: 235–247, 1980

    CAS  Google Scholar 

  • Raptis S, Dimitriadis G, Hadjidakis D. Acarbose treatment in insulin dependent (type 1) diabetes mellitus. In Creutzfeldt W (Ed.) Acarbose for the treatment of diabetes mellitus, pp. 141–152, Springer, New York, 1987

    Google Scholar 

  • Riccardi G, Rivellese A, Pocioni D, Genovese S, Mastranzo P, et al. Separate influence of dietary carbohydrate and fibre on the metabolic control in diabetes. Diabetologia 26: 116–121, 1984

    Article  PubMed  CAS  Google Scholar 

  • Sachse G. Acarbose in non-insulin-dependent diabetes. Long-term studies in combination with oral agents. In Creutzfeldt W (Ed.) Acarbose for the treatment of diabetes mellitus, pp. 92–111, Springer, New York, 1987

    Google Scholar 

  • Stout RW. Hyperinsulinaemia — a possible risk factor for cardio-vascular disease in diabetes mellitus. Hormone and Metabolic Research 15: 37–41, 1985

    CAS  Google Scholar 

  • Toeller M. Kohlenhydrate in der Diabeteskost. Ernährungs-Umschau 36: 363–368, 1989

    Google Scholar 

  • Toeller M. Diabetesschulung. Internist 31: 208–217, 1990a

    PubMed  CAS  Google Scholar 

  • Toeller M. Dietary treatment and α-glucosidase inhibitors in NIDDM. Diabetes, Nutrition and Metabolism. Clinical and Experimental 3 (Suppl. 1): 43–49, 1990b

    Google Scholar 

  • Toeller M. Diättherapie des Diabetes mellitus. Fortschritte der Medizin 2: 19–22, 1991a

    Google Scholar 

  • Toeller M. Modulation of intestinal glucose absorption: postponement of glucose absorption by α-glucosidase inhibitors. In Mogensen CE, Standl E (Eds) Pharmacology of diabetes. Present practice and future perspectives, pp. 93–112, Walter de Gruyter, New York, 1991b

    Google Scholar 

  • Toeller M. Inhibiteurs de l’α-gjucosidase. In Journés de diabétologie de l’Hotel-Dieu, pp. 203-212, Flammarion Médicine-Sciences, Paris, 1991c

  • Tuomilehto J. Acarbose monotherapy in the treatment of non-insulin-dependent diabetes mellitus: a review. In Creutzfeldt W (Ed.) Acarbose for the treatment of diabetes mellitus pp. 104–116, Springer, New York, 1987

    Google Scholar 

  • Van Gaal L, Vansant G, De Leeuw I. Upper body adiposity and the risk for atherosclerosis. Journal of the American College of Nutrition 8: 504–514, 1989

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Diabetes Research Institute, Heinrich-Heine-University, Düusseldorf, Germany

    M. Toeller

Authors
  1. M. Toeller
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Toeller, M. Nutritional Recommendations for Diabetic Patients and Treatment with α-Glucosidase Inhibitors. Drugs 44 (Suppl 3), 13–20 (1992). https://doi.org/10.2165/00003495-199200443-00003

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00003495-199200443-00003

Keywords

Search

Navigation