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Sumatriptan Delays Paracetamol Absorption in Migraine Patients

  • Clinical Pharmacokinetics
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Summary

The effect of sumatriptan 100mg orally on paracetamol absorption was evaluated in 9 migraine patients. Sumatriptan pretreatment significantly lowered the peak paracetamol concentration and also delayed the time to reach peak concentration. The paracetamol peak concentration decreased significantly from 36.28 ± 10.85 mg/L to 18.26 ± 6.7 mg/L, and the time to reach the peak was significantly delayed from 1.36 ± 0.38 hours to 2.72 ± 1.0 hours after sumatriptan treatment. The rate of absorption of paracetamol up to 3 hours was significantly reduced after sumatriptan administration. At 2 hours after sumatriptan administration, only 67% of total paracetamol was absorbed, while the absorption was 97% without sumatriptan. The total absorption of paracetamol at the end of the 8th hour was, however, not affected. These results suggest that in migraine patients there is a delay in gastric emptying time with sumatriptan. Further studies are warranted during the acute attack to elucidate the clinical significance of the present study findings.

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Authors and Affiliations

  1. Department of Clinical Pharmacology and Therapeutics, The Nizam’s Institute of Medical Sciences, Panjugutta, Hyderabad, 500 482, India

    P. Usha Rani,  M. U. R. Naidu (Head), T. Ramesh Kumar Rao, S. Mohan Das, J. C. Shobha, K. Ravi Sekhar, E. Chandra Sekhar & T. Vijay Kumar

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  1. P. Usha Rani
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  2. M. U. R. Naidu
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  3. T. Ramesh Kumar Rao
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  4. S. Mohan Das
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  5. J. C. Shobha
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  6. K. Ravi Sekhar
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  7. E. Chandra Sekhar
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  8. T. Vijay Kumar
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Usha Rani, P., Naidu, M.U.R., Ramesh Kumar Rao, T. et al. Sumatriptan Delays Paracetamol Absorption in Migraine Patients. Clin. Drug Invest. 11, 300–304 (1996). https://doi.org/10.2165/00044011-199611050-00006

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  • DOI: https://doi.org/10.2165/00044011-199611050-00006

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