Abstract
P. aeruginosa is a serious cause of infection with reported rates of mortality being up to 61%. Several studies evidenced a correlation between hospital mortality due to P. aeruginosa bloodstream infections and an inappropriate antimicrobial treatment. Increasing resistance in P. aeruginosa isolates complicates the selection of adequate empirical therapy in severe infections and P. aeruginosa is often indistinguishable from other gram-negative bacterial infections. For these reasons, present guidelines for the treatment of suspected P. aeruginosa bacteraemia recommend the rapid introduction of empirical antimicrobial therapy that includes at least one antipseudomonal agent until having microbiological results. Current consensus favours the use of empirical combination, balancing the potential for greater toxicity against the lower emergence of antimicrobial resistance and the greater killing that might be achieved by combination therapies acting synergistically. Advantages and disadvantages of combination therapy towards monotherapy for P. aeruginosa severe infections, current antibiotics used for P. aeruginosa severe infections and main studies published on this issue are reviewed.
Keywords: P. aeruginosa, infection, antibiotic, treatment, combination, beta-lactam, aminoglycosides, fluoroquinolones
Current Medicinal Chemistry
Title: Pseudomonas aeruginosa Serious Infections: Mono or Combination Antimicrobial Therapy?
Volume: 15 Issue: 5
Author(s): Matteo Bassetti, Elda Righi and Claudio Viscoli
Affiliation:
Keywords: P. aeruginosa, infection, antibiotic, treatment, combination, beta-lactam, aminoglycosides, fluoroquinolones
Abstract: P. aeruginosa is a serious cause of infection with reported rates of mortality being up to 61%. Several studies evidenced a correlation between hospital mortality due to P. aeruginosa bloodstream infections and an inappropriate antimicrobial treatment. Increasing resistance in P. aeruginosa isolates complicates the selection of adequate empirical therapy in severe infections and P. aeruginosa is often indistinguishable from other gram-negative bacterial infections. For these reasons, present guidelines for the treatment of suspected P. aeruginosa bacteraemia recommend the rapid introduction of empirical antimicrobial therapy that includes at least one antipseudomonal agent until having microbiological results. Current consensus favours the use of empirical combination, balancing the potential for greater toxicity against the lower emergence of antimicrobial resistance and the greater killing that might be achieved by combination therapies acting synergistically. Advantages and disadvantages of combination therapy towards monotherapy for P. aeruginosa severe infections, current antibiotics used for P. aeruginosa severe infections and main studies published on this issue are reviewed.
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Cite this article as:
Bassetti Matteo, Righi Elda and Viscoli Claudio, Pseudomonas aeruginosa Serious Infections: Mono or Combination Antimicrobial Therapy?, Current Medicinal Chemistry 2008; 15 (5) . https://dx.doi.org/10.2174/092986708783503186
DOI https://dx.doi.org/10.2174/092986708783503186 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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