Abstract
Thyroid stimulating hormone (TSH; also known as thyrotropin), binds cognate receptors on the surface of thyrocytes to regulate proliferation and thyroid hormone synthesis. This unidimensional view of TSH is being transformed as new evidence indicates that TSH acts on adipose tissue. Adipocyte inflammatory responses that predispose to cardiovascular disease may occur in thyroid disorders associated with elevated TSH levels.
Keywords: TSH, TSH receptor, adipocyte, interleukin 6, leptin, cardiovascular disease
Mini-Reviews in Medicinal Chemistry
Title: The Adipocyte as a Novel TSH Target
Volume: 8 Issue: 1
Author(s): A. Sorisky, T. T. Antunes and A. Gagnon
Affiliation:
Keywords: TSH, TSH receptor, adipocyte, interleukin 6, leptin, cardiovascular disease
Abstract: Thyroid stimulating hormone (TSH; also known as thyrotropin), binds cognate receptors on the surface of thyrocytes to regulate proliferation and thyroid hormone synthesis. This unidimensional view of TSH is being transformed as new evidence indicates that TSH acts on adipose tissue. Adipocyte inflammatory responses that predispose to cardiovascular disease may occur in thyroid disorders associated with elevated TSH levels.
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Cite this article as:
Sorisky A., Antunes T. T. and Gagnon A., The Adipocyte as a Novel TSH Target, Mini-Reviews in Medicinal Chemistry 2008; 8 (1) . https://dx.doi.org/10.2174/138955708783331531
DOI https://dx.doi.org/10.2174/138955708783331531 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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