Abstract
Repetitive transcranial magnetic stimulation (rTMS) is a well known non-invasive brain stimulation procedure which is capable of inducing the expression of the hippocampal BDNF that has been already shown to exert significant neuroprotective and pro-cognitive effects in AD. However, it is nearly impossible directly to evaluate the BDNF expression in humans after rTMS application. Here we summarized the underlying mechanisms of the neuroprotective and procognitive effect of BDNF that can be induced through a region-specific rTMS approach. Additionally, we have also evaluated the role of Magnetic Resonance Spectroscopy in monitoring the BDNF response after rTMS application in Alzheimer’s Disease. We have provided strong evidence that rTMS exerts significant neuroprotective and pro-cognitive effects through the expression of hippocampal BDNF. Furthermore, Magnetic Resonance Spectroscopy might play a critical role in monitoring the BDNF response after rTMS application in AD patients. Such a sophisticated approach might be able to enlighten us on the time-dependent cognitive and neuroprotective correlates of the rtMS application in AD patients.
Keywords: rTMS, BDNF, MRS, hippocampus, neuroprotective, AD patients.
Mini-Reviews in Medicinal Chemistry
Title:Beyond The Therapeutic Effect of rTMS in Alzheimer’s Disease: A Possible Neuroprotective Role of Hippocampal BDNF? : A Minireview
Volume: 18 Issue: 17
Author(s): Burak Yulug*, Lutfu Hanoglu, Elmir Khanmammadov, Ozge Arici Duz, Burcu Polat, Taha Hanoglu, Mehmet Yalcin Gunal and Ertugrul Kilic
Affiliation:
- Department of Neurology, Istanbul-Medipol University, Istanbul,Turkey
Keywords: rTMS, BDNF, MRS, hippocampus, neuroprotective, AD patients.
Abstract: Repetitive transcranial magnetic stimulation (rTMS) is a well known non-invasive brain stimulation procedure which is capable of inducing the expression of the hippocampal BDNF that has been already shown to exert significant neuroprotective and pro-cognitive effects in AD. However, it is nearly impossible directly to evaluate the BDNF expression in humans after rTMS application. Here we summarized the underlying mechanisms of the neuroprotective and procognitive effect of BDNF that can be induced through a region-specific rTMS approach. Additionally, we have also evaluated the role of Magnetic Resonance Spectroscopy in monitoring the BDNF response after rTMS application in Alzheimer’s Disease. We have provided strong evidence that rTMS exerts significant neuroprotective and pro-cognitive effects through the expression of hippocampal BDNF. Furthermore, Magnetic Resonance Spectroscopy might play a critical role in monitoring the BDNF response after rTMS application in AD patients. Such a sophisticated approach might be able to enlighten us on the time-dependent cognitive and neuroprotective correlates of the rtMS application in AD patients.
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Cite this article as:
Yulug Burak*, Hanoglu Lutfu, Khanmammadov Elmir , Duz Arici Ozge, Polat Burcu, Hanoglu Taha , Gunal Yalcin Mehmet and Kilic Ertugrul , Beyond The Therapeutic Effect of rTMS in Alzheimer’s Disease: A Possible Neuroprotective Role of Hippocampal BDNF? : A Minireview, Mini-Reviews in Medicinal Chemistry 2018; 18 (17) . https://dx.doi.org/10.2174/1389557517666170927162537
DOI https://dx.doi.org/10.2174/1389557517666170927162537 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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