Abstract
Astrocytes in the normal brain possess a stellate shape reflecting their non-migratory properties. Alternatively, in neurodegenerative diseases or after injury, astrocytes become “reactive” in a process known as astrocytosis or reactive gliosis, retract their processes, become polarized and acquire front-to-rear asymmetry typical of migratory cells. On the other hand, neuronal migration is a common process during embryonic development, but only few types of neurons can migrate and differentiate during adult life in the central nervous system. Those that do migrate follow tracks made by glial cells and mainly give rise to interneurons. In vitro, molecular mechanisms involved in adhesion of cells to and migration on extracellular matrix proteins have been widely studied; however, signal transduction pathways explaining how particularly neurons and astrocytes, mutually modulate adhesion and migration are less well known. In this review, we describe and discuss how ligand/receptor interactions in astrocytes and neurons trigger signaling events leading to actin and microtubule reorganization, changes in cell morphology, as well as cell adhesion and migration. The biological significance these cell-cell interactions and signaling events might have in the brain are discussed.
Keywords: Astrocytes, cell adhesion, cell migration, neurons, signaling pathways.
Current Molecular Medicine
Title:Signaling Pathways Involved in Neuron-Astrocyte Adhesion and Migration
Volume: 14 Issue: 2
Author(s): A. Cardenas, M. Kong, A. Alvarez, H. Maldonado and L. Leyton
Affiliation:
Keywords: Astrocytes, cell adhesion, cell migration, neurons, signaling pathways.
Abstract: Astrocytes in the normal brain possess a stellate shape reflecting their non-migratory properties. Alternatively, in neurodegenerative diseases or after injury, astrocytes become “reactive” in a process known as astrocytosis or reactive gliosis, retract their processes, become polarized and acquire front-to-rear asymmetry typical of migratory cells. On the other hand, neuronal migration is a common process during embryonic development, but only few types of neurons can migrate and differentiate during adult life in the central nervous system. Those that do migrate follow tracks made by glial cells and mainly give rise to interneurons. In vitro, molecular mechanisms involved in adhesion of cells to and migration on extracellular matrix proteins have been widely studied; however, signal transduction pathways explaining how particularly neurons and astrocytes, mutually modulate adhesion and migration are less well known. In this review, we describe and discuss how ligand/receptor interactions in astrocytes and neurons trigger signaling events leading to actin and microtubule reorganization, changes in cell morphology, as well as cell adhesion and migration. The biological significance these cell-cell interactions and signaling events might have in the brain are discussed.
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Cite this article as:
Cardenas A., Kong M., Alvarez A., Maldonado H. and Leyton L., Signaling Pathways Involved in Neuron-Astrocyte Adhesion and Migration, Current Molecular Medicine 2014; 14 (2) . https://dx.doi.org/10.2174/1566524014666140128113311
DOI https://dx.doi.org/10.2174/1566524014666140128113311 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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